Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   I6I02_RS07735 Genome accession   NZ_CP066093
Coordinates   1694245..1694988 (+) Length   247 a.a.
NCBI ID   WP_198463394.1    Uniprot ID   -
Organism   Streptococcus salivarius strain FDAARGOS_1045     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1681498..1711123 1694245..1694988 within 0
IScluster/Tn 1693069..1697914 1694245..1694988 within 0


Gene organization within MGE regions


Location: 1681498..1711123
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6I02_RS07680 (I6I02_07680) - 1681498..1682913 (+) 1416 WP_198463387.1 Y-family DNA polymerase -
  I6I02_RS07685 (I6I02_07685) - 1682910..1683269 (+) 360 WP_198463388.1 hypothetical protein -
  I6I02_RS07690 (I6I02_07690) - 1683975..1684388 (-) 414 WP_198463389.1 hypothetical protein -
  I6I02_RS07695 (I6I02_07695) - 1684813..1685658 (-) 846 WP_073689375.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
  I6I02_RS07700 (I6I02_07700) - 1685655..1686245 (-) 591 WP_198463390.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
  I6I02_RS07705 (I6I02_07705) xerS 1686556..1687629 (-) 1074 WP_045772541.1 tyrosine recombinase XerS -
  I6I02_RS07710 (I6I02_07710) - 1689127..1689330 (-) 204 WP_198463391.1 hypothetical protein -
  I6I02_RS07715 (I6I02_07715) - 1689360..1690343 (-) 984 WP_198463392.1 hypothetical protein -
  I6I02_RS07720 (I6I02_07720) - 1690336..1691766 (-) 1431 WP_198463393.1 hypothetical protein -
  I6I02_RS11135 - 1691933..1692364 (-) 432 Protein_1535 IS30 family transposase -
  I6I02_RS07725 (I6I02_07725) - 1692526..1692777 (-) 252 WP_232621261.1 transposase -
  I6I02_RS07730 (I6I02_07730) tnpA 1692961..1693434 (-) 474 Protein_1537 IS200/IS605 family transposase -
  I6I02_RS07735 (I6I02_07735) comE/blpR 1694245..1694988 (+) 744 WP_198463394.1 LytR/AlgR family response regulator transcription factor Regulator
  I6I02_RS07740 (I6I02_07740) - 1694998..1696314 (+) 1317 WP_198463395.1 sensor histidine kinase -
  I6I02_RS07745 (I6I02_07745) - 1697477..1697794 (-) 318 Protein_1540 transposase -
  I6I02_RS11035 - 1698066..1698740 (-) 675 Protein_1541 transposase -
  I6I02_RS07755 (I6I02_07755) ldcB 1698793..1703022 (-) 4230 WP_198463396.1 LD-carboxypeptidase LdcB/DacB -
  I6I02_RS07760 (I6I02_07760) - 1703373..1704338 (-) 966 WP_002890057.1 IS3 family transposase -
  I6I02_RS07765 (I6I02_07765) - 1704335..1705012 (-) 678 WP_002890056.1 helix-turn-helix domain-containing protein -
  I6I02_RS07770 (I6I02_07770) tnpA 1705196..1705669 (-) 474 WP_002891962.1 IS200/IS605 family transposase -
  I6I02_RS07775 (I6I02_07775) - 1705853..1706413 (-) 561 WP_198463397.1 transcriptional regulator -
  I6I02_RS11095 (I6I02_07780) - 1706544..1708388 (-) 1845 WP_198463398.1 SH3 domain-containing protein -
  I6I02_RS07785 (I6I02_07785) - 1709166..1710419 (+) 1254 WP_198463399.1 hypothetical protein -
  I6I02_RS07790 (I6I02_07790) - 1710500..1711123 (+) 624 WP_198463400.1 hypothetical protein -

Sequence

Protein


Download         Length: 247 a.a.        Molecular weight: 28690.07 Da        Isoelectric Point: 6.1726

>NTDB_id=517371 I6I02_RS07735 WP_198463394.1 1694245..1694988(+) (comE/blpR) [Streptococcus salivarius strain FDAARGOS_1045]
MLNIFILEDEFLQQTRIETVIKDVIAKKSLKCKGPEVFGKPSQLLDAITERGSHQLFFLDIEIKGEEKKGLDIAKEIRKK
DPNATIVFVTTHSEFMPVTFKYRVAALDFIDKALDDEDFYERVHLAIEYTMDKVGATIAQDSFTFETATAHVQVPFNNIL
FFETSPTIHKVILHTKEERMEFYASISEVERADDRLFRCHRSFIVNPENIVRINKEEKMVMFENNNECPISRTKYKALLE
KVKSLKS

Nucleotide


Download         Length: 744 bp        

>NTDB_id=517371 I6I02_RS07735 WP_198463394.1 1694245..1694988(+) (comE/blpR) [Streptococcus salivarius strain FDAARGOS_1045]
TTGTTAAATATTTTTATTTTAGAAGACGAATTTTTACAACAAACACGAATAGAGACCGTTATTAAGGATGTTATTGCAAA
AAAATCTCTAAAATGTAAAGGACCTGAGGTTTTTGGAAAACCTAGCCAGCTACTTGATGCGATTACCGAAAGAGGTTCTC
ATCAACTTTTCTTTTTAGATATTGAAATTAAAGGAGAAGAAAAAAAGGGGCTAGACATTGCGAAAGAAATCCGAAAAAAA
GACCCTAATGCAACAATTGTTTTTGTAACAACACATTCAGAATTTATGCCAGTCACTTTTAAATATAGAGTTGCTGCACT
AGATTTTATTGATAAAGCTTTAGACGATGAAGATTTTTATGAACGTGTTCATTTAGCAATTGAATATACCATGGATAAAG
TGGGTGCCACTATTGCCCAAGATTCTTTTACTTTTGAAACAGCTACGGCCCATGTTCAAGTGCCTTTTAACAATATCTTA
TTTTTTGAAACATCTCCAACAATACATAAAGTTATTTTGCATACTAAAGAAGAACGCATGGAGTTCTACGCCAGTATTTC
AGAAGTTGAACGAGCTGATGACCGCCTATTTCGATGCCATCGTTCATTTATCGTTAATCCTGAAAATATCGTAAGGATCA
ATAAGGAAGAGAAAATGGTAATGTTTGAAAATAATAATGAATGTCCCATTTCGCGTACGAAATATAAGGCCCTCCTAGAA
AAAGTTAAATCTTTGAAAAGCTAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(152-241)

Response regulator receiver domain (Response_reg)

(4-123)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.942

97.571

0.526
  comE/comE1 Streptococcus equinus JB1

45.679

98.381

0.449
  comE/comE2 Streptococcus equinus JB1

40.244

99.595

0.401
  comE/comE2 Streptococcus gordonii strain NCTC7865

38.057

100

0.381
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

38.057

100

0.381