Detailed information NTG0517207

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: I6H73_RS11185
• Genome accession: NZ_CP066073
• Coordinates: 2217342..2218253 (+)
• Length: 303 a.a.
• NCBI ID: WP_003060893.1
• Uniprot ID: A0AAE9U6L1
• Organism: Streptococcus dysgalactiae strain FDAARGOS_1016
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 2212342..2223253

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6H73_RS11160 (I6H73_11160)	purE	2212843..2213331 (+)	489	WP_003055559.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
I6H73_RS11165 (I6H73_11165)	purK	2213318..2214391 (+)	1074	WP_003055561.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
I6H73_RS11170 (I6H73_11170)	-	2214401..2215657 (+)	1257	WP_003055555.1	DUF4041 domain-containing protein	-
I6H73_RS11175 (I6H73_11175)	-	2215650..2215859 (+)	210	WP_014611912.1	hypothetical protein	-
I6H73_RS11180 (I6H73_11180)	purB	2215908..2217200 (+)	1293	WP_003056595.1	adenylosuccinate lyase	-
I6H73_RS11185 (I6H73_11185)	comR	2217342..2218253 (+)	912	WP_003060893.1	XRE family transcriptional regulator	Regulator
I6H73_RS11190	comS	2218340..2218438 (+)	99	WP_014611913.1	quorum-sensing system DWW-type pheromone	Regulator
I6H73_RS11195 (I6H73_11190)	ruvB	2218472..2219470 (+)	999	WP_003059357.1	Holliday junction branch migration DNA helicase RuvB	-
I6H73_RS11200 (I6H73_11195)	-	2219605..2220036 (+)	432	WP_003059365.1	low molecular weight protein-tyrosine-phosphatase	-
I6H73_RS11205 (I6H73_11200)	-	2220065..2220466 (+)	402	WP_003049089.1	MORN repeat-containing protein	-
I6H73_RS11210 (I6H73_11205)	-	2220463..2222238 (+)	1776	WP_003059359.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35995.62 Da
• Isoelectric Point: 4.7392

>NTDB_id=517207 I6H73_RS11185 WP_003060893.1 2217342..2218253(+) (comR) [Streptococcus dysgalactiae strain FDAARGOS_1016]
MLEHFGEKVRGLRLEKGISREELCGDEAELSVRQLARIELGQSIPSLAKVIFIAKALEVSVGYLTDGANLELPKRYKELK
YLILRTPTYMDDRKLQVRESQFDEIFENYYDQLPEEEKIAIDIIQAKFEVYQTGDINFGFNILKEFLPQLKKKTVYNLNE
LLLIDLYLIILVVSNFTNDLFDEEFYKEITERILEQHQYLLLEDLFLLNNILLSCADTSIRLKMFERLKDTLQLSHFIMS
TIQDFQRMPMYCMYEWKLSIFYLKDIKRAETYFSQSLTFTQMTNDSYLAQKLQKEWDKDIHPS

Nucleotide

• Length: 912 bp

>NTDB_id=517207 I6H73_RS11185 WP_003060893.1 2217342..2218253(+) (comR) [Streptococcus dysgalactiae strain FDAARGOS_1016]
ATGTTAGAGCATTTTGGTGAAAAAGTGAGAGGATTAAGACTTGAGAAAGGGATTAGTCGAGAGGAATTGTGTGGAGATGA
GGCAGAATTGTCTGTTCGCCAGTTGGCGAGGATAGAGCTAGGTCAATCTATACCAAGTTTAGCGAAGGTTATTTTTATTG
CGAAAGCCTTAGAGGTCAGCGTCGGTTATTTGACGGATGGCGCTAACCTAGAACTCCCTAAACGATATAAAGAGTTAAAA
TATCTCATTTTAAGGACTCCGACTTATATGGACGATCGCAAATTACAGGTCCGGGAGTCTCAGTTTGATGAGATATTTGA
AAACTATTATGATCAATTGCCCGAGGAGGAAAAAATAGCGATTGATATTATCCAGGCAAAATTTGAAGTTTATCAGACAG
GTGATATTAATTTTGGTTTTAATATTTTAAAAGAATTTCTACCACAACTAAAAAAGAAAACGGTTTATAACTTAAATGAA
TTATTATTAATTGATTTATATTTAATTATTTTAGTTGTTTCTAACTTTACAAATGACCTATTTGATGAGGAATTTTATAA
AGAAATAACGGAGCGAATCTTAGAACAGCATCAATACCTGTTATTAGAAGATTTATTTCTATTAAATAATATTCTTTTAT
CTTGCGCAGATACTTCTATTCGTTTAAAAATGTTTGAACGACTAAAGGATACGTTACAACTCAGCCATTTTATTATGTCA
ACCATTCAAGATTTTCAGCGAATGCCCATGTATTGCATGTATGAATGGAAATTGTCTATCTTTTATTTAAAAGATATTAA
ACGAGCAGAAACTTATTTTAGTCAATCTCTCACGTTTACTCAAATGACTAATGATAGTTATTTGGCACAAAAGCTTCAAA
AAGAATGGGATAAGGATATTCATCCCTCTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	83.389	99.34	0.828
comR	Streptococcus pyogenes MGAS8232	55.629	99.67	0.554
comR	Streptococcus mutans UA159	46.154	98.68	0.455
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.575	96.37	0.449
comR	Streptococcus suis P1/7	37.288	97.36	0.363
comR	Streptococcus suis 05ZYH33	37.288	97.36	0.363