Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   I6H78_RS01685 Genome accession   NZ_CP066059
Coordinates   353894..354568 (-) Length   224 a.a.
NCBI ID   WP_000590630.1    Uniprot ID   A0A4V0BT06
Organism   Streptococcus oralis strain FDAARGOS_1021     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 348894..359568
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6H78_RS01660 (I6H78_01660) - 349028..349957 (-) 930 WP_084851842.1 peptidase U32 family protein -
  I6H78_RS01665 (I6H78_01665) - 350083..350763 (-) 681 WP_198459736.1 ABC transporter ATP-binding protein -
  I6H78_RS01670 (I6H78_01670) - 350777..351832 (-) 1056 WP_198459737.1 ABC transporter permease -
  I6H78_RS01675 (I6H78_01675) - 352218..352502 (+) 285 WP_198459738.1 DUF3270 domain-containing protein -
  I6H78_RS01680 (I6H78_01680) ciaH 352567..353904 (-) 1338 WP_198459739.1 sensor histidine kinase Regulator
  I6H78_RS01685 (I6H78_01685) ciaR 353894..354568 (-) 675 WP_000590630.1 two-component system response regulator CiaR Regulator
  I6H78_RS01690 (I6H78_01690) - 354678..357224 (-) 2547 WP_198459740.1 M1 family metallopeptidase -
  I6H78_RS01695 (I6H78_01695) - 357345..357785 (-) 441 WP_198459741.1 ASCH domain-containing protein -
  I6H78_RS01700 (I6H78_01700) - 357782..358630 (-) 849 WP_198459742.1 putative PEP-binding protein -
  I6H78_RS01705 (I6H78_01705) - 358608..359108 (-) 501 WP_198459743.1 NUDIX hydrolase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25479.29 Da        Isoelectric Point: 4.2660

>NTDB_id=516932 I6H78_RS01685 WP_000590630.1 353894..354568(-) (ciaR) [Streptococcus oralis strain FDAARGOS_1021]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDIVVNLSTNEVKVEDTPVELLGKEFELLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=516932 I6H78_RS01685 WP_000590630.1 353894..354568(-) (ciaR) [Streptococcus oralis strain FDAARGOS_1021]
ATGATAAAAATCTTATTAGTAGAAGATGACCTAGGTCTGTCAAACTCAGTATTTGACTTTTTAGATGATTTTGCAGATGT
CATGCAGGTTTTTGATGGAGAAGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTTTGCTTGACCTGATGT
TACCTGAAAAAAATGGCTTCCAAGTCTTGAAAGAGTTGCGCGAAAAAGGAATTACCACACCAGTCCTTATCATGACGGCC
AAAGAAAGTTTGGATGACAAGGGACATGGTTTTGAGTTGGGAGCGGATGACTACCTCACCAAACCTTTCTATCTAGAAGA
ACTCAAAATGCGGATTCAAGCTCTTCTCAAACGTTCAGGTAAGTTTAACGAAAACACCTTGACCTATGGAGATATTGTCG
TCAACCTTTCAACGAATGAAGTGAAGGTGGAAGACACGCCTGTGGAACTACTCGGAAAAGAGTTTGAGTTATTGGTTTAT
TTCCTTCAAAACCAAAATGTTATTCTTCCCAAGACGCAAATTTTTGACCGTCTATGGGGGTTTGATAGCGATACGACGAT
TTCTGTTGTAGAAGTCTATGTCTCAAAAGTTCGTAAGAAATTGAAGGGAACAGCCTTTGCTGAAAATCTTCAAACCTTGC
GTAGTGTCGGGTATATTTTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4V0BT06

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae TIGR4

97.768

100

0.978
  ciaR Streptococcus pneumoniae D39

97.768

100

0.978
  ciaR Streptococcus pneumoniae R6

97.768

100

0.978
  ciaR Streptococcus pneumoniae Rx1

97.768

100

0.978
  ciaR Streptococcus mutans UA159

87.5

100

0.875
  vicR Streptococcus mutans UA159

36.481

100

0.379
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.283

100

0.366