Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   I6H90_RS05070 Genome accession   NZ_CP065995
Coordinates   1019208..1020347 (+) Length   379 a.a.
NCBI ID   WP_011680488.1    Uniprot ID   Q03UV5
Organism   Leuconostoc mesenteroides strain FDAARGOS_1033     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1014208..1025347
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6H90_RS05050 (I6H90_05050) yycF 1014365..1015072 (+) 708 WP_010281559.1 response regulator YycF -
  I6H90_RS05055 (I6H90_05055) walK 1015140..1017005 (+) 1866 WP_041775298.1 cell wall metabolism sensor histidine kinase WalK -
  I6H90_RS05060 (I6H90_05060) - 1016995..1018287 (+) 1293 WP_011680489.1 hypothetical protein -
  I6H90_RS05065 (I6H90_05065) yycI 1018344..1019147 (+) 804 WP_010289058.1 two-component system regulatory protein YycI -
  I6H90_RS05070 (I6H90_05070) htrA 1019208..1020347 (+) 1140 WP_011680488.1 trypsin-like peptidase domain-containing protein Regulator
  I6H90_RS05075 (I6H90_05075) rlmH 1020978..1021457 (+) 480 WP_011680487.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6H90_RS05080 (I6H90_05080) - 1021551..1023716 (+) 2166 WP_011680486.1 YhgE/Pip domain-containing protein -
  I6H90_RS05085 (I6H90_05085) - 1023770..1024222 (+) 453 WP_011680485.1 Rrf2 family transcriptional regulator -
  I6H90_RS05090 (I6H90_05090) - 1024307..1024972 (-) 666 WP_010285559.1 NAD(P)H-hydrate epimerase -

Sequence

Protein


Download         Length: 379 a.a.        Molecular weight: 39220.52 Da        Isoelectric Point: 9.7777

>NTDB_id=516172 I6H90_RS05070 WP_011680488.1 1019208..1020347(+) (htrA) [Leuconostoc mesenteroides strain FDAARGOS_1033]
MVQPALTKTLLTGVIAGVVGGGAILYGQQGVQLLQNQNQKVSTTATSTKTIAKNATATSAYNKVSDAVVSVLNFTKSSQG
SYQESSEGSGVIYKKTDGSAFIVTNNHVITGAAKIQVMLHSGKKVTATLVGKDAMTDLAVLKIDGTDVTTTAQFGDSSKI
TVGENVLAIGSPLGSEYASSVTQGIISAKKRLVEATSENGQNYGGSTVIQTDAAINPGNSGGPLINFAGQVIGINSMKLS
TSSSGTSVEGMGFAIPSDQVVDIVNKLVKDGKVTRPAIGISLINLSEVTASEQKSTLKIPDSVTGGVVVMSLTNNGPADK
AGLKKYDVIVGINGKKVSSQADLREELYKHSLGDTITLTYYHQDTKQTVKVKLTQKLAS

Nucleotide


Download         Length: 1140 bp        

>NTDB_id=516172 I6H90_RS05070 WP_011680488.1 1019208..1020347(+) (htrA) [Leuconostoc mesenteroides strain FDAARGOS_1033]
ATGGTACAACCAGCATTAACAAAAACGTTGTTAACTGGCGTCATTGCTGGTGTTGTTGGTGGAGGAGCAATTTTGTATGG
GCAGCAGGGTGTACAATTGTTACAAAATCAAAATCAAAAAGTGAGTACGACAGCAACAAGTACAAAAACGATTGCCAAGA
ATGCAACTGCTACATCAGCTTATAATAAGGTATCAGATGCAGTTGTATCTGTATTGAACTTTACTAAATCCAGTCAAGGT
AGTTATCAAGAATCGTCAGAAGGTTCTGGCGTGATCTATAAAAAAACGGATGGATCGGCATTTATTGTAACGAATAATCA
CGTAATCACTGGAGCGGCTAAAATTCAAGTTATGCTGCACAGTGGGAAGAAAGTGACCGCTACATTAGTCGGCAAAGATG
CGATGACTGACTTAGCTGTTCTGAAAATCGACGGCACAGACGTTACAACAACTGCACAATTTGGCGATTCAAGTAAAATA
ACTGTTGGTGAAAACGTCTTGGCAATTGGTTCGCCGCTGGGATCTGAGTATGCTTCGTCAGTGACGCAAGGCATCATTTC
GGCCAAGAAAAGGTTAGTTGAGGCAACATCTGAAAATGGTCAAAATTATGGTGGATCCACGGTTATTCAGACGGATGCTG
CTATTAATCCTGGTAACTCAGGTGGACCATTAATCAACTTTGCAGGACAAGTTATTGGTATTAACTCAATGAAGTTATCA
ACATCTTCTTCTGGAACGAGCGTTGAGGGGATGGGTTTTGCAATTCCTTCTGATCAAGTCGTTGACATTGTTAACAAATT
AGTCAAAGATGGTAAAGTCACACGACCAGCAATTGGCATTAGTTTGATTAATTTGTCAGAAGTAACAGCTTCTGAGCAAA
AATCAACATTGAAAATTCCAGATAGCGTTACTGGTGGTGTTGTTGTAATGAGTTTGACTAACAATGGCCCAGCAGATAAA
GCTGGATTGAAGAAGTACGACGTTATTGTTGGCATTAATGGTAAAAAGGTCAGCTCACAGGCTGATCTGCGAGAAGAACT
CTACAAGCATTCGCTTGGGGACACAATAACATTGACTTATTATCATCAGGATACTAAGCAAACCGTCAAGGTTAAATTAA
CACAGAAATTAGCAAGCTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(276-373)

Peptidase family M50 (Peptidase_M50)

(221-375)

Trypsin-like peptidase domain (Trypsin_2)

(88-234)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q03UV5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

52.394

93.668

0.491
  htrA Streptococcus gordonii str. Challis substr. CH1

48.549

100

0.485
  htrA Streptococcus pneumoniae D39

52.924

90.237

0.478
  htrA Streptococcus pneumoniae TIGR4

52.924

90.237

0.478
  htrA Streptococcus pneumoniae R6

52.924

90.237

0.478
  htrA Streptococcus pneumoniae Rx1

52.924

90.237

0.478
  htrA Streptococcus mutans UA159

52.647

89.71

0.472