Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   I6H90_RS04030 Genome accession   NZ_CP065995
Coordinates   826350..828497 (+) Length   715 a.a.
NCBI ID   WP_011679063.1    Uniprot ID   Q03ZY6
Organism   Leuconostoc mesenteroides strain FDAARGOS_1033     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 821350..833497
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6H90_RS03985 (I6H90_03985) - 821967..822947 (+) 981 WP_242824524.1 GHKL domain-containing protein -
  I6H90_RS03990 (I6H90_03990) - 822953..823678 (+) 726 WP_011679068.1 response regulator transcription factor -
  I6H90_RS03995 (I6H90_03995) - 823950..824162 (-) 213 WP_011679067.1 hypothetical protein -
  I6H90_RS04000 (I6H90_04000) - 824168..824308 (-) 141 WP_166668083.1 hypothetical protein -
  I6H90_RS04005 (I6H90_04005) - 824623..824799 (-) 177 WP_010287275.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  I6H90_RS04010 (I6H90_04010) - 824961..825140 (-) 180 WP_010287277.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  I6H90_RS04015 (I6H90_04015) - 825155..825292 (-) 138 WP_011679065.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  I6H90_RS04020 (I6H90_04020) - 825751..825912 (-) 162 WP_010287029.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  I6H90_RS04025 (I6H90_04025) - 825943..826119 (-) 177 WP_010287032.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  I6H90_RS04030 (I6H90_04030) comA 826350..828497 (+) 2148 WP_011679063.1 peptide cleavage/export ABC transporter Regulator
  I6H90_RS04035 (I6H90_04035) - 828515..829864 (+) 1350 WP_011679062.1 bacteriocin secretion accessory protein -
  I6H90_RS04040 (I6H90_04040) - 830687..830812 (-) 126 WP_011679061.1 putative metal homeostasis protein -
  I6H90_RS04045 (I6H90_04045) - 830928..831665 (-) 738 WP_002815471.1 SDR family NAD(P)-dependent oxidoreductase -
  I6H90_RS04050 (I6H90_04050) - 831723..832310 (-) 588 WP_002815470.1 helix-turn-helix transcriptional regulator -

Sequence

Protein


Download         Length: 715 a.a.        Molecular weight: 80382.34 Da        Isoelectric Point: 9.2370

>NTDB_id=516168 I6H90_RS04030 WP_011679063.1 826350..828497(+) (comA) [Leuconostoc mesenteroides strain FDAARGOS_1033]
MRKFHYISQLEEKDCGVAALAMILKRHGSDVSLANIRERCQTSLSGTTALGLVKAAESFNMDVRPIQADLTLFNMKDLPL
PFIAHVEKKGQYLHYYVVYGFTKNKVIIADPDPTVAKTAMTLQEFSKEWTGVALFMSPSPRYKPFKENKNSILSFLPIIS
RQKGLIANIVVASLLVTLISIAGSYYMQLVIDTYIPSAMSNTLTVVSLGLIATYVLQQLLSFARTYLLTIMGQRLSIEVI
LSYIRHLFELPVNFFATRRTGEIVTRFNDANTIIDAMANTILSLFLDLGITIIVGSVLAIQNTKLFLLSLISFPIYFLIV
YCFMKPFERLNQEQMASNATLSSSIIEDINGIETIKSLTSEKTSYQKIDREFIDYLKKSFAHQKSEAIQNSIKQATQLII
NVLVLWLGAKLVISNQISVGQLVTYNALLGYFTEPFQNIINLQAKLQTATVANRRLNEVYLVKSEFKKSESQELHHNNPH
NITVDDVSYQYGYQKNILHHFSIKIPFGEKIALVGVSGSGKSTLAKLLVHFISPSAGNIFIGEQNIKHVQRQNLRQHILY
LPQNPYIFTGSILDNLTLGARENTTQEDILHAVELADIKDDIENMPQSYQTEISEEGGMSGGQKQRIALARALLSNSQIL
ILDESTSNLDVATEKKIIDNLLSLKNKTIIFIAHRLTIAEKVQRVILLEKGIISEDGSHAELIHKKSKYYHLVKH

Nucleotide


Download         Length: 2148 bp        

>NTDB_id=516168 I6H90_RS04030 WP_011679063.1 826350..828497(+) (comA) [Leuconostoc mesenteroides strain FDAARGOS_1033]
ATGAGAAAGTTTCATTATATATCACAACTTGAAGAAAAAGATTGTGGCGTAGCAGCACTAGCTATGATTTTAAAGCGACA
CGGCTCAGATGTTTCATTAGCTAACATTCGTGAACGCTGTCAAACATCCCTATCGGGTACAACGGCGCTAGGCTTAGTGA
AGGCCGCTGAATCATTCAATATGGATGTCCGTCCTATTCAAGCTGACCTTACCTTATTTAACATGAAAGATTTGCCTCTG
CCGTTCATCGCTCATGTTGAGAAAAAAGGTCAATATTTGCATTATTATGTAGTGTACGGATTCACTAAAAACAAAGTTAT
CATTGCAGATCCAGATCCAACAGTTGCTAAAACCGCAATGACGTTACAAGAATTCTCTAAAGAGTGGACTGGTGTAGCAT
TGTTCATGTCGCCTTCACCCAGATATAAACCTTTTAAAGAAAATAAAAACAGTATCCTATCCTTTCTGCCAATTATTAGT
CGACAAAAAGGATTAATTGCTAATATTGTCGTCGCTTCTTTGCTAGTCACTTTAATTAGTATCGCTGGCTCTTATTATAT
GCAACTAGTGATTGATACTTATATTCCTAGTGCTATGTCTAACACATTAACCGTTGTTTCATTAGGACTCATTGCCACCT
ATGTGTTACAACAGCTACTTAGTTTTGCTCGCACCTATCTGTTAACTATTATGGGACAACGATTATCGATTGAAGTCATA
CTATCATACATACGGCACTTGTTCGAATTACCTGTTAATTTCTTTGCCACACGTCGAACAGGTGAAATTGTCACGCGTTT
TAATGACGCCAACACCATTATTGATGCCATGGCAAATACAATTCTCTCACTTTTTTTAGATTTAGGTATCACGATAATTG
TTGGCAGCGTCTTAGCAATTCAAAATACAAAACTTTTTCTGCTATCTCTAATCTCTTTTCCTATCTACTTCTTGATTGTC
TATTGTTTCATGAAGCCATTTGAACGATTGAATCAAGAACAGATGGCAAGTAATGCAACGCTGAGCTCATCTATTATTGA
AGACATCAATGGTATTGAAACCATAAAATCTTTGACAAGCGAGAAGACGAGCTACCAAAAAATTGATCGTGAATTTATCG
ATTATTTAAAAAAATCCTTTGCCCATCAAAAAAGCGAAGCCATTCAAAATAGTATTAAACAAGCAACTCAACTCATTATC
AATGTGCTCGTTTTATGGTTGGGTGCCAAGCTAGTGATTAGTAATCAAATTAGTGTCGGTCAGTTAGTTACCTATAATGC
ATTACTAGGCTACTTTACTGAACCTTTCCAAAATATTATTAACTTGCAGGCGAAATTACAAACGGCAACGGTTGCTAACC
GACGATTAAACGAAGTCTATCTTGTAAAATCAGAGTTTAAAAAATCAGAATCACAAGAGCTTCATCATAACAACCCTCAT
AACATTACAGTTGACGACGTCAGCTATCAATATGGTTATCAAAAGAACATATTACACCACTTTTCAATTAAGATCCCCTT
TGGTGAAAAAATTGCTCTGGTCGGTGTTAGCGGTTCCGGTAAGTCAACATTAGCCAAACTACTTGTTCATTTTATATCTC
CTAGTGCTGGCAACATTTTTATTGGTGAACAAAACATTAAACACGTTCAACGACAAAATTTAAGGCAACATATTCTTTAT
CTACCACAAAACCCATACATATTTACTGGAAGCATATTAGATAATTTAACACTAGGTGCTCGTGAAAACACAACACAAGA
AGACATCCTACATGCTGTTGAGCTTGCTGACATTAAAGATGACATCGAAAATATGCCACAAAGTTATCAAACCGAAATTT
CAGAGGAAGGCGGCATGTCTGGAGGCCAAAAGCAGCGTATCGCTTTAGCTAGAGCCCTCCTTAGTAATTCTCAAATACTT
ATTTTGGATGAATCAACCAGTAATCTTGATGTCGCAACTGAAAAAAAGATTATTGATAATTTATTATCGCTTAAAAATAA
AACAATCATTTTTATTGCACATCGCCTGACTATTGCTGAAAAAGTCCAACGCGTTATTCTGCTTGAAAAAGGGATCATCA
GTGAAGATGGTAGCCATGCTGAACTTATACATAAAAAATCAAAATACTATCATCTTGTAAAGCATTAA

Domains

Predicted by InterproScan.

ABC transporter (ABC_tran)

(498-647)

Peptidase C39 family (Peptidase_C39)

(3-140)

ABC transporter transmembrane region (ABC_membrane)

(168-436)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q03ZY6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus gordonii str. Challis substr. CH1

59.944

99.86

0.599
  comA Streptococcus mitis NCTC 12261

58.287

99.58

0.58
  comA Streptococcus mitis SK321

58.006

99.58

0.578
  comA Streptococcus pneumoniae Rx1

57.725

99.58

0.575
  comA Streptococcus pneumoniae D39

57.725

99.58

0.575
  comA Streptococcus pneumoniae R6

57.725

99.58

0.575
  comA Streptococcus pneumoniae TIGR4

57.444

99.58

0.572
  comA/nlmT Streptococcus mutans UA159

54.149

99.441

0.538