Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   I6H76_RS06965 Genome accession   NZ_CP065994
Coordinates   1362502..1364649 (-) Length   715 a.a.
NCBI ID   WP_043878344.1    Uniprot ID   A0A380KR24
Organism   Streptococcus infantarius strain FDAARGOS_1019     
Function   transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1365589..1373648 1362502..1364649 flank 940


Gene organization within MGE regions


Location: 1362502..1373648
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6H76_RS06965 (I6H76_06965) comA/nlmT 1362502..1364649 (-) 2148 WP_043878344.1 peptide cleavage/export ABC transporter Regulator
  I6H76_RS06970 (I6H76_06970) - 1364924..1365181 (+) 258 WP_006531864.1 bacteriocin class II family protein -
  I6H76_RS06975 (I6H76_06975) - 1365199..1365393 (+) 195 WP_043878345.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  I6H76_RS06980 (I6H76_06980) - 1365589..1365816 (+) 228 WP_006531867.1 Blp family class II bacteriocin -
  I6H76_RS06985 (I6H76_06985) - 1365818..1366006 (+) 189 WP_115283782.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  I6H76_RS06990 (I6H76_06990) - 1366475..1366633 (+) 159 WP_006531869.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  I6H76_RS06995 (I6H76_06995) - 1366661..1366816 (+) 156 WP_006531870.1 bacteriocin -
  I6H76_RS07000 (I6H76_07000) - 1366856..1367530 (+) 675 WP_006531871.1 CPBP family intramembrane glutamic endopeptidase -
  I6H76_RS07005 (I6H76_07005) - 1367871..1368173 (+) 303 WP_006531872.1 hypothetical protein -
  I6H76_RS07010 (I6H76_07010) - 1368252..1368455 (+) 204 WP_081442276.1 garvicin Q family class II bacteriocin -
  I6H76_RS07015 (I6H76_07015) - 1368467..1368769 (+) 303 WP_006531874.1 bacteriocin immunity protein -
  I6H76_RS07020 (I6H76_07020) - 1368927..1369160 (+) 234 WP_006531875.1 Blp family class II bacteriocin -
  I6H76_RS07025 (I6H76_07025) - 1369180..1369368 (+) 189 WP_006531876.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  I6H76_RS07030 (I6H76_07030) - 1370118..1370336 (+) 219 WP_006531878.1 Blp family class II bacteriocin -
  I6H76_RS07035 (I6H76_07035) - 1370336..1370632 (+) 297 WP_006531879.1 bacteriocin immunity protein -
  I6H76_RS07040 (I6H76_07040) - 1370801..1371034 (+) 234 WP_006531880.1 Blp family class II bacteriocin -
  I6H76_RS07045 (I6H76_07045) - 1371224..1371424 (+) 201 WP_006531882.1 bacteriocin class II family protein -
  I6H76_RS07050 (I6H76_07050) - 1371450..1371632 (+) 183 WP_006531883.1 Blp family class II bacteriocin -
  I6H76_RS07055 (I6H76_07055) - 1372250..1372480 (+) 231 WP_043878356.1 bacteriocin -
  I6H76_RS07060 (I6H76_07060) - 1372569..1372880 (+) 312 WP_003066586.1 hypothetical protein -
  I6H76_RS07065 (I6H76_07065) - 1373094..1373186 (+) 93 Protein_1343 Blp family class II bacteriocin -
  I6H76_RS07070 (I6H76_07070) - 1373244..1373648 (+) 405 WP_018364981.1 hypothetical protein -

Sequence

Protein


Download         Length: 715 a.a.        Molecular weight: 80171.07 Da        Isoelectric Point: 7.4929

>NTDB_id=516145 I6H76_RS06965 WP_043878344.1 1362502..1364649(-) (comA/nlmT) [Streptococcus infantarius strain FDAARGOS_1019]
MRRYKYVSQIDLRDCGVAALASVAKHYGSDFSLAHLRELAKTTKEGTTALGIVEAAKAIGFETRAIQANMELFDMADIPY
PFIVHVNKEGKLQHYYVVYKAKKNHLIIGDPDPSVKVTKMPKERFKKEWTGVAIFLAPAPHYQPHKDKKNGLTSFLPIIF
KQKALLTYIILASLLVTLINIVGSYYLQGILDDYIPNQLQSTLGIVSVGLIVTYIMQQIMSFSQNYLLVVLSQRLTIDVI
LSYIRHIFELPMSFFATRRTGEVISRFTDANSIIDALASTILSLFLDVSILFIVGSVLILQNTNLFFITLIALPIYAIII
LAFMKPFERMNHDVMQANSMVSSAIIEDINGIETIKSLTSEEVRYQNIDREFVDYLDKSFTLSKYEAVQTSLKQGAQLIL
NVAILWYGSRLVMAGNISVGQLITYNTLLSYFTTPMENIINLQTKLQSAKVANNRLNEVYLVSSEFDSKQLLNDSHFLQG
DIVFDDVSYKYGFGRDTLSHVNLHIKKGEKISLVGISGSGKTTLAKMIVNFYTPNHGQITLGGYDLKTIDKKAIRQYINY
LPQQSYVFSGTILENLTLGAPDNITQEEILKACEIAEIRADIELMPLAYHTELSDGAGLSGGQKQRLALARALLTQAPVL
ILDEATSGLDVLTEKRVIKNLLSLTDKTIIFVAHRLSIAEQSDRVIVLDKGHVIEEGHHKQLIQNQGFYAQLFHE

Nucleotide


Download         Length: 2148 bp        

>NTDB_id=516145 I6H76_RS06965 WP_043878344.1 1362502..1364649(-) (comA/nlmT) [Streptococcus infantarius strain FDAARGOS_1019]
ATGAGGAGATACAAGTATGTTAGTCAGATTGATTTGCGAGATTGTGGTGTGGCAGCTTTGGCATCAGTTGCCAAGCATTA
TGGATCTGATTTCTCACTGGCACACCTAAGGGAATTAGCTAAAACAACTAAGGAAGGGACGACAGCGTTAGGGATAGTCG
AGGCAGCTAAAGCCATTGGCTTTGAAACACGCGCCATTCAAGCTAACATGGAACTGTTTGATATGGCCGATATTCCCTAT
CCTTTTATTGTTCATGTTAACAAAGAAGGCAAACTGCAGCACTATTATGTCGTTTACAAAGCTAAGAAAAACCACCTTAT
CATCGGTGATCCAGACCCCAGTGTCAAAGTGACCAAAATGCCCAAGGAGCGCTTTAAAAAGGAATGGACAGGTGTCGCCA
TTTTCTTAGCACCTGCTCCGCATTATCAACCGCATAAAGATAAGAAAAATGGCTTAACAAGCTTTTTACCAATTATTTTC
AAACAAAAGGCACTGCTAACTTATATCATTCTGGCAAGTTTGCTCGTGACCTTGATTAACATTGTTGGGTCTTACTATTT
GCAAGGAATCTTAGACGATTATATTCCTAATCAATTGCAATCCACTCTTGGCATTGTCTCGGTTGGGTTGATTGTAACCT
ACATAATGCAACAAATCATGAGCTTTTCACAAAATTATTTACTTGTTGTGCTGAGCCAACGGTTAACAATTGACGTGATT
TTGTCTTATATTCGTCACATTTTTGAATTGCCCATGTCTTTTTTTGCCACAAGGCGGACAGGTGAAGTGATCTCACGTTT
CACCGATGCTAACTCGATTATTGATGCACTGGCATCAACGATTCTCTCTTTATTTTTAGATGTGAGTATTTTGTTTATTG
TCGGAAGTGTCTTAATTCTGCAAAATACCAATCTCTTTTTCATCACCTTAATAGCATTGCCTATCTATGCTATTATTATT
TTGGCTTTTATGAAGCCTTTTGAGCGAATGAATCACGATGTCATGCAAGCCAATTCTATGGTTAGCTCTGCGATTATCGA
AGATATCAATGGTATTGAAACGATTAAATCTTTGACTAGTGAGGAAGTCCGTTATCAAAATATTGACCGTGAATTTGTGG
ATTATTTGGATAAAAGTTTTACGCTTAGTAAGTATGAAGCTGTGCAAACGTCGTTAAAACAGGGAGCACAGCTAATTTTA
AACGTCGCCATTCTCTGGTATGGTTCACGTTTAGTCATGGCTGGGAACATTTCAGTAGGACAATTGATTACTTACAATAC
GCTTCTGTCGTACTTTACAACGCCAATGGAAAATATTATCAATCTGCAAACCAAACTACAATCTGCCAAAGTAGCTAATA
ATCGTCTCAACGAAGTTTACTTAGTGTCATCTGAATTTGATAGCAAACAACTCTTAAATGACAGCCATTTTCTACAAGGA
GATATTGTTTTTGATGATGTTTCTTATAAATATGGTTTTGGTCGTGACACGCTGAGTCATGTGAATTTACACATTAAGAA
AGGTGAAAAAATTAGCCTAGTTGGTATCAGCGGCTCTGGTAAGACAACCTTAGCTAAAATGATTGTCAATTTTTACACAC
CTAACCATGGACAGATTACCCTTGGTGGCTACGATTTAAAAACCATTGATAAAAAAGCCATTCGTCAATACATTAATTAC
CTACCACAACAGTCTTACGTCTTTTCAGGGACAATTTTAGAAAATTTAACCTTGGGAGCACCTGACAATATCACGCAAGA
AGAAATTCTGAAAGCTTGTGAAATCGCTGAAATCCGTGCTGATATTGAATTGATGCCACTAGCATACCATACCGAACTTT
CAGATGGTGCTGGGTTATCTGGTGGGCAAAAGCAACGTTTAGCTTTAGCACGCGCTTTACTGACACAAGCTCCCGTCTTG
ATTTTAGATGAAGCCACAAGTGGTCTTGATGTTCTAACGGAAAAACGTGTGATTAAAAATTTACTATCTCTCACAGACAA
AACTATTATTTTTGTTGCCCACCGTTTGAGCATTGCTGAACAATCTGACCGTGTCATTGTTCTAGATAAAGGACACGTTA
TCGAAGAAGGGCATCATAAACAACTCATCCAAAATCAAGGTTTCTATGCACAGTTATTTCATGAATAA

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(3-140)

ABC transporter (ABC_tran)

(498-647)

ABC transporter transmembrane region (ABC_membrane)

(166-436)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A380KR24

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

71.108

99.72

0.709
  comA Streptococcus mitis NCTC 12261

67.746

99.301

0.673
  comA Streptococcus pneumoniae Rx1

67.373

99.021

0.667
  comA Streptococcus pneumoniae D39

67.373

99.021

0.667
  comA Streptococcus pneumoniae R6

67.373

99.021

0.667
  comA Streptococcus mitis SK321

67.183

99.301

0.667
  comA Streptococcus pneumoniae TIGR4

67.09

99.021

0.664
  comA Streptococcus gordonii str. Challis substr. CH1

66.199

99.72

0.66