Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   I6I14_RS04450 Genome accession   NZ_CP065992
Coordinates   971841..973127 (+) Length   428 a.a.
NCBI ID   WP_010737045.1    Uniprot ID   A0A2A4DST9
Organism   Enterococcus hirae strain FDAARGOS_1057     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 966841..978127
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6I14_RS04435 (I6I14_04435) - 967479..969125 (-) 1647 WP_034700432.1 membrane protein -
  I6I14_RS04440 (I6I14_04440) - 970005..970853 (-) 849 WP_034700434.1 LEM-3-like GIY-YIG domain-containing protein -
  I6I14_RS04445 (I6I14_04445) rlmH 970909..971388 (-) 480 WP_034700436.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6I14_RS04450 (I6I14_04450) htrA 971841..973127 (+) 1287 WP_010737045.1 S1C family serine protease Regulator
  I6I14_RS04455 (I6I14_04455) ytpR 973185..973790 (-) 606 WP_010737044.1 YtpR family tRNA-binding protein -
  I6I14_RS04460 (I6I14_04460) - 974100..974567 (-) 468 WP_002317107.1 universal stress protein -
  I6I14_RS04465 (I6I14_04465) - 974597..974917 (-) 321 WP_002317106.1 thioredoxin family protein -
  I6I14_RS04470 (I6I14_04470) pepA 975454..976533 (-) 1080 WP_034700438.1 glutamyl aminopeptidase -
  I6I14_RS04475 (I6I14_04475) - 976732..977085 (+) 354 WP_002317104.1 PepSY domain-containing protein -

Sequence

Protein


Download         Length: 428 a.a.        Molecular weight: 44581.68 Da        Isoelectric Point: 4.7976

>NTDB_id=516056 I6I14_RS04450 WP_010737045.1 971841..973127(+) (htrA) [Enterococcus hirae strain FDAARGOS_1057]
MERKDVTPKMKKNNGIWRKLGLGLVGGIIGGLVTAGIFYAVMGSGNAASNSGGHQNSAGETVVENVKVNVDSDITNAVDK
VQDAVVSVINLQSQNQGTNGFGQLFGQQQQESSDDSNLEASSEGSGVIYKKSGNSAYIVTNNHVVEGQQGLEVLLKDGTK
VKAELVGTDAYSDLAVLKISADKVNKVASFGDSNSLKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNQTVN
INAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSASSSGVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGITM
VDLSAVSTQQQEQILKIPESVTNGVIVTSVQPATPAEKAGLKQYDVITKIDDTDVSSGVELQSVLYQKKVGDSVKVTYYR
GKEKKTTTIQLTIDQSALKQSQSENSGN

Nucleotide


Download         Length: 1287 bp        

>NTDB_id=516056 I6I14_RS04450 WP_010737045.1 971841..973127(+) (htrA) [Enterococcus hirae strain FDAARGOS_1057]
ATGGAGAGAAAAGATGTGACACCAAAAATGAAAAAGAATAATGGAATCTGGCGTAAGCTGGGTCTAGGCTTAGTCGGTGG
AATTATTGGGGGCTTGGTAACGGCTGGTATTTTTTATGCTGTCATGGGTTCTGGAAACGCAGCGTCAAATTCAGGTGGTC
ATCAAAATTCAGCGGGCGAAACTGTCGTTGAGAATGTCAAAGTCAATGTCGATTCAGATATTACGAATGCGGTCGATAAA
GTCCAAGATGCGGTGGTATCTGTTATCAATCTTCAAAGCCAAAATCAAGGGACTAACGGCTTCGGTCAACTATTTGGCCA
ACAACAACAAGAAAGTTCTGATGATAGCAATCTAGAGGCTTCTAGTGAAGGTAGTGGTGTCATCTACAAAAAAAGTGGCA
ATTCCGCTTATATCGTAACAAATAATCACGTAGTAGAAGGACAACAAGGATTAGAGGTTTTATTAAAAGATGGAACAAAA
GTCAAAGCTGAATTAGTCGGGACGGATGCTTATTCTGACTTAGCCGTTTTGAAAATCAGTGCAGATAAAGTGAACAAAGT
TGCTTCATTTGGTGACTCTAATTCATTGAAAGTAGGTGAACCTGCGATCGCAATTGGTTCTCCTCTAGGTTCTGAATATG
CCAACTCTGTGACTTCGGGGATTATCTCTTCATTGAATCGCCAAGTAACCAGCACGAACGAGTCAAATCAAACGGTCAAT
ATCAATGCGATCCAAACAGATGCTGCGATCAACCCTGGTAATTCTGGTGGTCCATTAGTCAATATTGAAGGACAAGTGAT
CGGGATCAATTCAAGTAAAATTGCAAGTACTTCTGCTTCTTCATCAGGTGTAAGCGTGGAAGGAATGGGCTTTGCGATCC
CAAGTAACGATGTAGTAAATATTATCAACCAACTTGAAAAAGATGGAAAAGTAACCCGTCCTGCTCTAGGGATCACAATG
GTTGACCTTTCAGCCGTTTCAACCCAACAACAAGAACAAATCTTGAAAATTCCTGAGTCTGTGACAAATGGTGTGATTGT
TACCAGCGTTCAACCGGCGACACCTGCAGAAAAAGCTGGCTTGAAACAATATGATGTCATTACAAAAATCGATGATACTG
ATGTTTCTTCTGGTGTAGAATTACAATCTGTCTTGTATCAGAAAAAAGTCGGCGATTCAGTGAAGGTCACTTACTATCGC
GGAAAAGAAAAGAAAACAACAACGATTCAATTAACAATTGATCAATCCGCATTAAAACAAAGCCAATCAGAGAACTCTGG
TAACTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(124-269)

PDZ domain (PDZ_2)

(314-411)

Peptidase family M50 (Peptidase_M50)

(12-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2A4DST9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

54.545

92.523

0.505
  htrA Streptococcus gordonii str. Challis substr. CH1

53.35

94.159

0.502
  htrA Streptococcus pneumoniae Rx1

58.457

78.738

0.46
  htrA Streptococcus pneumoniae D39

58.457

78.738

0.46
  htrA Streptococcus pneumoniae R6

58.457

78.738

0.46
  htrA Streptococcus pneumoniae TIGR4

58.457

78.738

0.46
  htrA Streptococcus mitis NCTC 12261

57.567

78.738

0.453