Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   I8F49_RS01140 Genome accession   NZ_CP065752
Coordinates   228262..229551 (-) Length   429 a.a.
NCBI ID   WP_002319485.1    Uniprot ID   -
Organism   Enterococcus faecium strain 18-465     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 223262..234551
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I8F49_RS01110 (I8F49_01105) - 223663..224610 (-) 948 WP_002289860.1 glycosyltransferase family 2 protein -
  I8F49_RS01115 (I8F49_01110) - 224833..225183 (-) 351 WP_002289862.1 PepSY domain-containing protein -
  I8F49_RS01120 (I8F49_01115) pepA 225383..226462 (+) 1080 WP_002294156.1 glutamyl aminopeptidase -
  I8F49_RS01125 (I8F49_01120) - 226605..226925 (+) 321 WP_002287837.1 thioredoxin family protein -
  I8F49_RS01130 (I8F49_01125) - 226947..227411 (+) 465 WP_002292633.1 universal stress protein -
  I8F49_RS01135 (I8F49_01130) ytpR 227618..228223 (+) 606 WP_002294153.1 YtpR family tRNA-binding protein -
  I8F49_RS01140 (I8F49_01135) htrA 228262..229551 (-) 1290 WP_002319485.1 S1C family serine protease Regulator
  I8F49_RS01145 (I8F49_01140) rlmH 229980..230459 (+) 480 WP_002287841.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I8F49_RS01150 (I8F49_01145) - 230951..231631 (+) 681 WP_002331383.1 IS6-like element IS1216 family transposase -
  I8F49_RS12530 - 231878..232189 (+) 312 WP_256737298.1 hypothetical protein -
  I8F49_RS01160 (I8F49_01155) - 232383..233529 (-) 1147 Protein_231 IS3 family transposase -
  I8F49_RS01165 (I8F49_01160) - 233684..233944 (+) 261 WP_002328071.1 hypothetical protein -

Sequence

Protein


Download         Length: 429 a.a.        Molecular weight: 44898.89 Da        Isoelectric Point: 4.5419

>NTDB_id=513979 I8F49_RS01140 WP_002319485.1 228262..229551(-) (htrA) [Enterococcus faecium strain 18-465]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1290 bp        

>NTDB_id=513979 I8F49_RS01140 WP_002319485.1 228262..229551(-) (htrA) [Enterococcus faecium strain 18-465]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTAGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAGAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGGACTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACGAATAATCACGTAGTAGATGGCCAGCAAGGTCTTGAAGTCTTGATGAAAGAC
GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGT
CGAAACAGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAGCCTGCGATTGCGATTGGTTCCCCACTAGGAT
CTGAATATGCAAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTGACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTTAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(10-417)

PDZ domain (PDZ_2)

(317-414)

Trypsin-like peptidase domain (Trypsin_2)

(127-272)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

54.569

91.841

0.501
  htrA Streptococcus mutans UA159

59.887

82.517

0.494
  htrA Streptococcus mitis NCTC 12261

52.778

92.308

0.487
  htrA Streptococcus pneumoniae TIGR4

59.05

78.555

0.464
  htrA Streptococcus pneumoniae Rx1

59.05

78.555

0.464
  htrA Streptococcus pneumoniae D39

59.05

78.555

0.464
  htrA Streptococcus pneumoniae R6

59.05

78.555

0.464