Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   SPAF_RS02745 Genome accession   NC_017905
Coordinates   536211..536948 (+) Length   245 a.a.
NCBI ID   WP_003004768.1    Uniprot ID   I1ZKF6
Organism   Streptococcus parasanguinis FW213     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 531211..541948
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPAF_RS02730 (Spaf_0516) - 531544..533106 (-) 1563 WP_014712948.1 ABC transporter substrate-binding protein/permease -
  SPAF_RS02735 (Spaf_0517) - 533224..535131 (+) 1908 WP_041826240.1 DUF2207 domain-containing protein -
  SPAF_RS02740 (Spaf_0519) - 535240..536076 (+) 837 WP_013904699.1 undecaprenyl-diphosphate phosphatase -
  SPAF_RS02745 (Spaf_0520) mecA 536211..536948 (+) 738 WP_003004768.1 adaptor protein MecA Regulator
  SPAF_RS02750 (Spaf_0522) - 536945..538102 (+) 1158 WP_023919310.1 MraY family glycosyltransferase -
  SPAF_RS02755 (Spaf_0523) sufC 538239..539009 (+) 771 WP_014712952.1 Fe-S cluster assembly ATPase SufC -
  SPAF_RS02760 (Spaf_0524) sufD 539076..540338 (+) 1263 WP_014712953.1 Fe-S cluster assembly protein SufD -
  SPAF_RS02765 (Spaf_0525) - 540348..541574 (+) 1227 WP_014712954.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28238.84 Da        Isoelectric Point: 4.0867

>NTDB_id=51116 SPAF_RS02745 WP_003004768.1 536211..536948(+) (mecA) [Streptococcus parasanguinis FW213]
MKMKQISDSTIKITIQLEDLEERGMEIADFLVPQEKTEEFFYAILDELEMPESFLDSGMLSFRVTPKPDKLDVFVTKSKI
DQQLDFEDLSDLPDMEELSRMTPDEFIKTLEKTISDKTKGDAEAIHHLEQEELRDNQEQDPTSEAPVSQYIYYILRFSNI
QQAVAFSKTVSFPVDTSELYKMGSDYYLTVLIDTEDQPNQYPTWLLAIIREYADDSEVTRAVLQEHGHLLMVSGAIENLK
KVASL

Nucleotide


Download         Length: 738 bp        

>NTDB_id=51116 SPAF_RS02745 WP_003004768.1 536211..536948(+) (mecA) [Streptococcus parasanguinis FW213]
ATGAAGATGAAGCAAATTAGTGATTCAACAATTAAGATCACGATCCAACTAGAAGACTTAGAAGAACGTGGGATGGAAAT
TGCTGATTTCCTTGTCCCACAAGAAAAAACAGAAGAATTTTTCTACGCTATTTTGGATGAGCTCGAAATGCCAGAAAGCT
TCCTGGATAGCGGGATGCTTAGTTTTCGTGTGACACCAAAACCAGATAAACTGGATGTTTTTGTTACCAAATCAAAAATT
GACCAACAATTGGATTTTGAGGATTTGTCAGATCTTCCTGATATGGAAGAGTTGTCACGCATGACGCCAGATGAATTTAT
CAAAACCTTGGAAAAAACAATCTCTGATAAGACAAAAGGGGATGCAGAAGCTATCCACCATTTGGAACAAGAAGAGTTGC
GGGACAATCAAGAACAAGATCCTACATCTGAAGCACCAGTAAGTCAGTATATTTATTACATTTTGCGTTTTTCAAATATC
CAGCAAGCAGTTGCCTTTTCAAAAACGGTCAGCTTTCCAGTGGATACCTCTGAATTATACAAAATGGGATCTGATTATTA
TTTAACTGTCTTGATCGATACAGAGGATCAACCAAATCAATATCCAACCTGGTTACTTGCTATCATTCGGGAGTATGCGG
ATGATTCAGAAGTGACACGGGCCGTTCTGCAGGAACATGGTCATTTATTAATGGTGTCTGGTGCGATTGAGAATTTGAAG
AAAGTTGCTAGCTTATGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I1ZKF6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

68.571

100

0.686
  mecA Streptococcus pneumoniae D39

68.571

100

0.686
  mecA Streptococcus pneumoniae R6

68.571

100

0.686
  mecA Streptococcus pneumoniae TIGR4

68.571

100

0.686
  mecA Streptococcus mutans UA159

49.798

100

0.502
  mecA Streptococcus thermophilus LMD-9

47.561

100

0.478
  mecA Streptococcus thermophilus LMG 18311

47.154

100

0.473

Multiple sequence alignment