Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   ST4145_RS01640 Genome accession   NZ_CP065492
Coordinates   299574..300263 (+) Length   229 a.a.
NCBI ID   WP_014607969.1    Uniprot ID   A0A2H4K9N5
Organism   Streptococcus thermophilus strain 4145     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 294574..305263
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ST4145_RS01615 - 295540..295710 (+) 171 Protein_265 ascorbate 6-phosphate lactonase -
  ST4145_RS01620 (ST4145_01610) - 295727..296398 (-) 672 WP_002946492.1 TrkA family potassium uptake protein -
  ST4145_RS01625 (ST4145_01615) - 296438..297802 (-) 1365 WP_014727321.1 potassium transporter TrkG -
  ST4145_RS01630 (ST4145_01620) rsmG 297872..298585 (-) 714 WP_002946490.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  ST4145_RS01635 (ST4145_01625) - 298882..299418 (+) 537 WP_024009735.1 YceD family protein -
  ST4145_RS01640 (ST4145_01630) covR 299574..300263 (+) 690 WP_014607969.1 response regulator transcription factor Regulator
  ST4145_RS01645 (ST4145_01635) covS 300260..301777 (+) 1518 WP_014607970.1 HAMP domain-containing histidine kinase Regulator
  ST4145_RS01650 (ST4145_01640) nrdR 301899..302378 (+) 480 WP_347126891.1 transcriptional regulator NrdR -
  ST4145_RS01655 (ST4145_01645) - 302375..303550 (+) 1176 WP_011680739.1 DnaD domain protein -
  ST4145_RS01660 (ST4145_01650) dnaI 303554..304456 (+) 903 WP_014607971.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26637.73 Da        Isoelectric Point: 4.7059

>NTDB_id=510883 ST4145_RS01640 WP_014607969.1 299574..300263(+) (covR) [Streptococcus thermophilus strain 4145]
MSKRILIVEDERNLARFVSLELQHEGYDVVTADNGREGLELALEKDFDLILLDLMLPEMDGFEVTRRLQQEKDTYIMMMT
ARDSIMDIVAGLDRGADDYIIKPFAIEELLARIRATFRRQDIEATKKAPAKASTYRDLKLDVQNRAVVRGDEVIPLTKRE
FDLLNTLLSNMNQVMTREELLLQVWKYDDVIETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIRER

Nucleotide


Download         Length: 690 bp        

>NTDB_id=510883 ST4145_RS01640 WP_014607969.1 299574..300263(+) (covR) [Streptococcus thermophilus strain 4145]
ATGAGCAAACGCATTTTGATTGTTGAAGATGAGAGAAACCTTGCTCGTTTTGTCTCTCTTGAACTTCAACACGAAGGATA
CGACGTTGTGACAGCGGACAACGGACGCGAAGGACTTGAATTGGCACTTGAGAAAGATTTCGATCTTATTCTCTTGGACC
TTATGTTGCCTGAGATGGACGGTTTCGAAGTGACACGTCGTCTCCAACAAGAAAAAGATACTTATATTATGATGATGACA
GCTCGCGACTCAATCATGGATATTGTTGCTGGTTTGGATCGTGGAGCTGATGACTATATTATAAAACCATTTGCGATTGA
AGAACTGTTGGCACGTATTCGTGCAACCTTCCGTCGTCAAGATATCGAAGCTACTAAGAAGGCACCAGCTAAAGCGTCAA
CCTATCGCGATTTAAAATTGGATGTTCAAAACCGTGCAGTTGTTCGCGGTGATGAGGTAATTCCATTGACAAAACGTGAG
TTTGATTTGTTGAACACACTTTTAAGCAATATGAACCAAGTAATGACCCGTGAGGAACTCTTGCTTCAAGTCTGGAAATA
TGATGACGTAATTGAAACAAACGTTGTAGATGTTTATATTCGTTACTTACGTGGGAAAATCGACATTCCAGGTAAGGAAT
CATACATTCAGACAGTACGAGGGATGGGTTACGTTATCCGTGAAAGATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(152-225)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2H4K9N5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

95.633

100

0.956
  covR Lactococcus lactis subsp. lactis strain DGCC12653

67.544

99.563

0.672
  vicR Streptococcus mutans UA159

45.259

100

0.459
  micA Streptococcus pneumoniae Cp1015

43.913

100

0.441