Detailed information    

insolico Bioinformatically predicted

Overview

Name   covS   Type   Regulator
Locus tag   ST4145_RS01645 Genome accession   NZ_CP065492
Coordinates   300260..301777 (+) Length   505 a.a.
NCBI ID   WP_014607970.1    Uniprot ID   A0A2H4K9K6
Organism   Streptococcus thermophilus strain 4145     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 295260..306777
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ST4145_RS01615 - 295540..295710 (+) 171 Protein_265 ascorbate 6-phosphate lactonase -
  ST4145_RS01620 (ST4145_01610) - 295727..296398 (-) 672 WP_002946492.1 TrkA family potassium uptake protein -
  ST4145_RS01625 (ST4145_01615) - 296438..297802 (-) 1365 WP_014727321.1 potassium transporter TrkG -
  ST4145_RS01630 (ST4145_01620) rsmG 297872..298585 (-) 714 WP_002946490.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  ST4145_RS01635 (ST4145_01625) - 298882..299418 (+) 537 WP_024009735.1 YceD family protein -
  ST4145_RS01640 (ST4145_01630) covR 299574..300263 (+) 690 WP_014607969.1 response regulator transcription factor Regulator
  ST4145_RS01645 (ST4145_01635) covS 300260..301777 (+) 1518 WP_014607970.1 HAMP domain-containing histidine kinase Regulator
  ST4145_RS01650 (ST4145_01640) nrdR 301899..302378 (+) 480 WP_347126891.1 transcriptional regulator NrdR -
  ST4145_RS01655 (ST4145_01645) - 302375..303550 (+) 1176 WP_011680739.1 DnaD domain protein -
  ST4145_RS01660 (ST4145_01650) dnaI 303554..304456 (+) 903 WP_014607971.1 primosomal protein DnaI -
  ST4145_RS01665 (ST4145_01655) der 304562..305872 (+) 1311 WP_011680741.1 ribosome biogenesis GTPase Der -
  ST4145_RS01670 (ST4145_01660) - 305936..306595 (+) 660 Protein_276 HI_0552 family protein -

Sequence

Protein


Download         Length: 505 a.a.        Molecular weight: 57550.96 Da        Isoelectric Point: 5.2689

>NTDB_id=510884 ST4145_RS01645 WP_014607970.1 300260..301777(+) (covS) [Streptococcus thermophilus strain 4145]
MSKLFGKVTIRKKLTMTTAVVFFLVLSMFTLVVVFSANTLLLQRERQNVNNTISKVVTYIEKDWDSDEELSPEPLLAALY
SPKNIYPSIINGVLSEKRSLDGQVAVSNRLYSNQSIYVYDKKGTFIFTSEEDTDSPPGMSEVNKLKLVSYKGKRGFLLQV
PIYGKDKKTIVGYAQVFHDLEFYYALKERLIFLLIFLEVGMTVLVIAVTVVVLTSILRPMRQLHETMGIIIDSPSDLELR
SKIESHDEIGALALNFNCMMDKIQENNQMQMRFLSDVSHELRTPIAVIKGHMDLLQRWGKNDPEILEESLEAASHEANRM
TIMINDMLDSIRVKGSFDNHRNDTCDLNSSIRTVIGNFRVLHDDYQFYLNDSEGSDRPAQIYSQHFEQVITILIDNAVKY
SPVNKKIQITIKALEDEMLVQVQDNGEGISKEDIEHIFERFYRSDKARNRTTTQSGVGIGLSILYQIVEAYRCHIDVSSE
LGVGTRFDLYIPFAESETTTPQIEG

Nucleotide


Download         Length: 1518 bp        

>NTDB_id=510884 ST4145_RS01645 WP_014607970.1 300260..301777(+) (covS) [Streptococcus thermophilus strain 4145]
ATGAGTAAATTATTTGGTAAAGTAACCATTAGAAAAAAGTTGACCATGACAACTGCTGTGGTCTTCTTTCTTGTATTGTC
GATGTTCACTCTGGTTGTTGTATTTTCAGCCAATACGCTTCTTTTGCAACGTGAACGTCAAAATGTAAATAATACAATCT
CAAAAGTTGTTACTTATATCGAAAAGGACTGGGACTCTGATGAAGAGTTGAGTCCAGAGCCGCTTTTAGCGGCCCTTTAT
TCACCGAAAAATATCTATCCATCAATCATTAATGGAGTGCTTTCTGAAAAGCGTTCCTTAGATGGTCAAGTTGCGGTTTC
TAATAGATTATATTCCAACCAGTCTATCTATGTTTATGACAAAAAGGGAACTTTTATCTTTACTTCTGAGGAGGATACAG
ACTCACCTCCAGGCATGTCTGAGGTCAATAAACTGAAGTTGGTTTCCTATAAAGGTAAACGTGGTTTCTTACTACAAGTT
CCAATCTATGGCAAGGATAAGAAGACCATTGTTGGGTATGCTCAAGTTTTCCATGATTTGGAATTCTACTATGCGTTAAA
AGAGCGTTTAATTTTCCTATTGATATTCCTTGAAGTAGGAATGACGGTCTTAGTTATTGCAGTAACTGTAGTTGTCTTGA
CATCTATTCTTCGTCCGATGAGGCAGTTACACGAAACGATGGGTATTATTATCGATTCGCCAAGTGATTTGGAGCTTCGA
TCTAAGATTGAGAGTCATGATGAGATTGGTGCTTTGGCACTTAACTTTAACTGTATGATGGATAAAATTCAAGAAAATAA
TCAGATGCAGATGCGTTTCTTGAGTGACGTCAGTCACGAATTACGTACTCCCATTGCAGTTATTAAAGGACATATGGACC
TCTTGCAACGTTGGGGTAAAAATGATCCTGAAATCCTTGAAGAAAGTCTTGAAGCTGCAAGTCACGAAGCCAACCGTATG
ACGATTATGATTAACGATATGTTGGATTCTATTCGTGTTAAAGGGTCATTTGACAATCATAGAAATGATACATGTGATTT
GAATTCTTCAATCCGTACGGTTATTGGGAATTTTCGTGTCCTACATGACGACTACCAATTCTACCTCAATGATTCTGAGG
GTTCAGATCGTCCAGCACAGATTTACAGCCAGCACTTTGAACAGGTTATTACTATTTTGATTGATAATGCGGTCAAGTAT
TCGCCTGTTAATAAGAAAATCCAGATTACTATCAAGGCTCTGGAAGATGAGATGCTGGTACAGGTACAGGATAATGGTGA
GGGTATCTCTAAAGAAGATATTGAACATATATTTGAACGCTTCTATCGTTCAGATAAGGCGCGTAATCGTACGACAACCC
AATCTGGTGTGGGTATTGGTTTATCAATCCTCTATCAAATTGTGGAAGCTTATCGATGCCATATCGATGTCAGTTCAGAA
CTTGGTGTGGGTACACGTTTTGACCTCTACATTCCTTTTGCAGAGTCAGAAACTACGACACCTCAAATTGAAGGTTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(384-494)

ArlS sensor domain (ArlS_N)

(39-187)

His Kinase A (phospho-acceptor) domain (HisKA)

(270-329)

HAMP domain (HAMP)

(213-265)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2H4K9K6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covS Streptococcus salivarius strain HSISS4

94.422

99.406

0.939