Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   ST4145_RS00990 Genome accession   NZ_CP065492
Coordinates   171794..172543 (+) Length   249 a.a.
NCBI ID   WP_024009711.1    Uniprot ID   -
Organism   Streptococcus thermophilus strain 4145     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 166794..177543
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ST4145_RS00965 (ST4145_00955) - 167369..167539 (+) 171 WP_023909348.1 hypothetical protein -
  ST4145_RS00970 (ST4145_00960) - 167820..168560 (-) 741 WP_002949253.1 amino acid ABC transporter ATP-binding protein -
  ST4145_RS00975 (ST4145_00965) - 168560..170110 (-) 1551 WP_014607891.1 ABC transporter substrate-binding protein/permease -
  ST4145_RS00980 (ST4145_00970) - 170313..171167 (+) 855 WP_014607892.1 undecaprenyl-diphosphate phosphatase -
  ST4145_RS00985 (ST4145_00975) - 171313..171528 (-) 216 WP_011226805.1 DUF3021 family protein -
  ST4145_RS00990 (ST4145_00980) mecA 171794..172543 (+) 750 WP_024009711.1 adaptor protein MecA Regulator
  ST4145_RS00995 (ST4145_00985) - 172547..173704 (+) 1158 WP_014607894.1 MraY family glycosyltransferase -
  ST4145_RS01000 (ST4145_00990) sufC 173864..174634 (+) 771 WP_002947634.1 Fe-S cluster assembly ATPase SufC -
  ST4145_RS01005 (ST4145_00995) sufD 174671..175933 (+) 1263 WP_002947640.1 Fe-S cluster assembly protein SufD -
  ST4145_RS01010 (ST4145_01000) - 175987..177219 (+) 1233 WP_011225367.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29095.63 Da        Isoelectric Point: 4.0624

>NTDB_id=510876 ST4145_RS00990 WP_024009711.1 171794..172543(+) (mecA) [Streptococcus thermophilus strain 4145]
MEMKQINETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEDLDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTGPAKEVAEETIREDYTHYVLAF
SDFDQVVTFAQGLKNVSVEGSELYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL
PVLQATKWS

Nucleotide


Download         Length: 750 bp        

>NTDB_id=510876 ST4145_RS00990 WP_024009711.1 171794..172543(+) (mecA) [Streptococcus thermophilus strain 4145]
ATGGAAATGAAACAAATAAACGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT
GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT
TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT
AAGGAAGACCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT
TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG
ATGAGACTATGACAGGGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC
TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAACTTTATAAACTTGG
TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus thermophilus LMD-9

98.795

100

0.988
  mecA Streptococcus thermophilus LMG 18311

98.795

100

0.988
  mecA Streptococcus mutans UA159

58.197

97.992

0.57
  mecA Streptococcus pneumoniae Rx1

46.185

100

0.462
  mecA Streptococcus pneumoniae D39

46.185

100

0.462
  mecA Streptococcus pneumoniae R6

46.185

100

0.462
  mecA Streptococcus pneumoniae TIGR4

46.185

100

0.462