Detailed information NTG0510756

Bioinformatically predicted

Overview

• Name: mecA
• Type: Regulator
• Locus tag: STCNRZ1575_RS01065
• Genome accession: NZ_CP065490
• Coordinates: 180437..181186 (+)
• Length: 249 a.a.
• NCBI ID: WP_011225365.1
• Uniprot ID: Q5M699
• Organism: Streptococcus thermophilus strain CNRZ1575
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 175437..186186

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STCNRZ1575_RS01035 (STCNRZ1575_01050)	-	176012..176182 (+)	171	WP_023909348.1	hypothetical protein	-
STCNRZ1575_RS01040 (STCNRZ1575_01055)	-	176269..176376 (+)	108	WP_002949251.1	LPXTG cell wall anchor domain-containing protein	-
STCNRZ1575_RS01045 (STCNRZ1575_01060)	-	176463..177203 (-)	741	WP_002949253.1	amino acid ABC transporter ATP-binding protein	-
STCNRZ1575_RS01050 (STCNRZ1575_01065)	-	177203..178753 (-)	1551	WP_260214242.1	ABC transporter substrate-binding protein/permease	-
STCNRZ1575_RS01055 (STCNRZ1575_01070)	-	178956..179810 (+)	855	WP_014607892.1	undecaprenyl-diphosphate phosphatase	-
STCNRZ1575_RS01060 (STCNRZ1575_01075)	-	179956..180171 (-)	216	WP_011226805.1	DUF3021 family protein	-
STCNRZ1575_RS01065 (STCNRZ1575_01080)	mecA	180437..181186 (+)	750	WP_011225365.1	adaptor protein MecA	Regulator
STCNRZ1575_RS01070 (STCNRZ1575_01085)	-	181190..182347 (+)	1158	WP_014621088.1	MraY family glycosyltransferase	-
STCNRZ1575_RS01075 (STCNRZ1575_01090)	sufC	182508..183278 (+)	771	WP_002947634.1	Fe-S cluster assembly ATPase SufC	-
STCNRZ1575_RS01080 (STCNRZ1575_01095)	sufD	183315..184577 (+)	1263	WP_260214241.1	Fe-S cluster assembly protein SufD	-
STCNRZ1575_RS01085 (STCNRZ1575_01100)	-	184631..185863 (+)	1233	WP_260214240.1	cysteine desulfurase	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29157.70 Da
• Isoelectric Point: 4.0659

>NTDB_id=510756 STCNRZ1575_RS01065 WP_011225365.1 180437..181186(+) (mecA) [Streptococcus thermophilus strain CNRZ1575]
MEMKQINETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEALDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAF
SDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL
PVLQATKWS

Nucleotide

• Length: 750 bp

>NTDB_id=510756 STCNRZ1575_RS01065 WP_011225365.1 180437..181186(+) (mecA) [Streptococcus thermophilus strain CNRZ1575]
ATGGAAATGAAACAAATAAACGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT
GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT
TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT
AAGGAAGCCCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT
TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG
ATGAGACTATGACAGAGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC
TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAATTTTATAAACTTGG
TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

• Negative regulator of genetic competence (MecA) (MecA) (1-242)

3D structure

• AlphaFold DB: Q5M699

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
mecA	Streptococcus thermophilus LMG 18311	100	100	1
mecA	Streptococcus thermophilus LMD-9	99.197	100	0.992
mecA	Streptococcus mutans UA159	57.377	97.992	0.562
mecA	Streptococcus pneumoniae Rx1	46.185	100	0.462
mecA	Streptococcus pneumoniae D39	46.185	100	0.462
mecA	Streptococcus pneumoniae R6	46.185	100	0.462
mecA	Streptococcus pneumoniae TIGR4	46.185	100	0.462