NTDB

Overview

Name	mecA	Type	Regulator
Locus tag	STMM20_RS09060	Genome accession	NZ_CP065485
Coordinates	1782563..1783312 (-)	Length	249 a.a.
NCBI ID	WP_226003740.1	Uniprot ID	-
Organism	Streptococcus thermophilus strain MM20
Function	degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 1777563..1788312

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STMM20_RS09040 (STMM20_09005)	-	1777887..1779119 (-)	1233	WP_011225367.1	cysteine desulfurase	-
STMM20_RS09045 (STMM20_09010)	sufD	1779173..1780435 (-)	1263	WP_011680669.1	Fe-S cluster assembly protein SufD	-
STMM20_RS09050 (STMM20_09015)	sufC	1780472..1781242 (-)	771	WP_002947634.1	Fe-S cluster assembly ATPase SufC	-
STMM20_RS09055 (STMM20_09020)	-	1781402..1782559 (-)	1158	WP_014621088.1	MraY family glycosyltransferase	-
STMM20_RS09060 (STMM20_09025)	mecA	1782563..1783312 (-)	750	WP_226003740.1	adaptor protein MecA	Regulator
STMM20_RS09065 (STMM20_09030)	-	1783596..1783886 (+)	291	WP_223899616.1	DUF3021 family protein	-
STMM20_RS09070 (STMM20_09035)	-	1783938..1784792 (-)	855	WP_011680666.1	undecaprenyl-diphosphate phosphatase	-
STMM20_RS09075 (STMM20_09040)	-	1784995..1786545 (+)	1551	WP_011680665.1	ABC transporter substrate-binding protein/permease	-
STMM20_RS09080 (STMM20_09045)	-	1786545..1787285 (+)	741	WP_002949253.1	amino acid ABC transporter ATP-binding protein	-
STMM20_RS09085	-	1787372..1787557 (-)	186	WP_347103554.1	LPXTG cell wall anchor domain-containing protein	-
STMM20_RS09090 (STMM20_09055)	-	1787566..1787736 (-)	171	WP_011680664.1	hypothetical protein	-

Sequence

Protein

Download Length: 249 a.a. Molecular weight: 29140.66 Da Isoelectric Point: 4.0481

                                >NTDB_id=510506 STMM20_RS09060 WP_226003740.1 1782563..1783312(-) (mecA) [Streptococcus thermophilus strain MM20]

MEMKQISETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL

KEDLDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAF

SDFDQVVTFAQGLKNVSVEGSELYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL

PVLQATKWS

Nucleotide

Download Length: 750 bp

                                >NTDB_id=510506 STMM20_RS09060 WP_226003740.1 1782563..1783312(-) (mecA) [Streptococcus thermophilus strain MM20]

ATGGAAATGAAACAAATAAGCGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT

GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT

TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT

AAGGAAGACCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT

TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG

ATGAGACTATGACAGAGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC

TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAACTTTATAAACTTGG

TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC

TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA

CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
mecA	Streptococcus thermophilus LMD-9	99.598	100	0.996
mecA	Streptococcus thermophilus LMG 18311	98.795	100	0.988
mecA	Streptococcus mutans UA159	58.197	97.992	0.57
mecA	Streptococcus pneumoniae Rx1	46.988	100	0.47
mecA	Streptococcus pneumoniae D39	46.988	100	0.47
mecA	Streptococcus pneumoniae R6	46.988	100	0.47
mecA	Streptococcus pneumoniae TIGR4	46.988	100	0.47

Detailed information NTG0510506