NTDB

Overview

Name	mecA	Type	Regulator
Locus tag	ST4134_RS01010	Genome accession	NZ_CP065478
Coordinates	170785..171534 (+)	Length	249 a.a.
NCBI ID	WP_011680667.1	Uniprot ID	Q03MN5
Organism	Streptococcus thermophilus strain 4134
Function	degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 165785..176534

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ST4134_RS00980 (ST4134_00965)	-	166361..166531 (+)	171	WP_011680664.1	hypothetical protein	-
ST4134_RS00985 (ST4134_00970)	-	166618..166725 (+)	108	WP_011226802.1	LPXTG cell wall anchor domain-containing protein	-
ST4134_RS00990 (ST4134_00975)	-	166812..167552 (-)	741	WP_002949253.1	amino acid ABC transporter ATP-binding protein	-
ST4134_RS00995 (ST4134_00980)	-	167552..169102 (-)	1551	WP_011680665.1	ABC transporter substrate-binding protein/permease	-
ST4134_RS01000 (ST4134_00985)	-	169305..170159 (+)	855	WP_011680666.1	undecaprenyl-diphosphate phosphatase	-
ST4134_RS01005 (ST4134_00990)	-	170211..170519 (-)	309	WP_306496352.1	DUF3021 family protein	-
ST4134_RS01010 (ST4134_00995)	mecA	170785..171534 (+)	750	WP_011680667.1	adaptor protein MecA	Regulator
ST4134_RS01015 (ST4134_01000)	-	171538..172695 (+)	1158	WP_002947632.1	glycosyltransferase family 4 protein	-
ST4134_RS01020 (ST4134_01005)	sufC	172855..173625 (+)	771	WP_002947634.1	Fe-S cluster assembly ATPase SufC	-
ST4134_RS01025 (ST4134_01010)	sufD	173662..174924 (+)	1263	WP_011680669.1	Fe-S cluster assembly protein SufD	-
ST4134_RS01030 (ST4134_01015)	-	174978..176210 (+)	1233	WP_011680670.1	cysteine desulfurase	-

Sequence

Protein

Download Length: 249 a.a. Molecular weight: 29174.68 Da Isoelectric Point: 4.0481

                                >NTDB_id=510043 ST4134_RS01010 WP_011680667.1 170785..171534(+) (mecA) [Streptococcus thermophilus strain 4134]

MEMKQISETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL

KEDLDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAF

SDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL

PVLQATKWS

Nucleotide

Download Length: 750 bp

                                >NTDB_id=510043 ST4134_RS01010 WP_011680667.1 170785..171534(+) (mecA) [Streptococcus thermophilus strain 4134]

ATGGAAATGAAACAAATAAGCGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT

GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT

TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT

AAGGAAGACCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT

TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG

ATGAGACTATGACAGAGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC

TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAATTTTATAAACTTGG

TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC

TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA

CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	Q03MN5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
mecA	Streptococcus thermophilus LMD-9	100	100	1
mecA	Streptococcus thermophilus LMG 18311	99.197	100	0.992
mecA	Streptococcus mutans UA159	57.787	97.992	0.566
mecA	Streptococcus pneumoniae Rx1	46.586	100	0.466
mecA	Streptococcus pneumoniae D39	46.586	100	0.466
mecA	Streptococcus pneumoniae R6	46.586	100	0.466
mecA	Streptococcus pneumoniae TIGR4	46.586	100	0.466

Detailed information NTG0510043