NTDB

Overview

Name	micA	Type	Regulator
Locus tag	I5W22_RS06300	Genome accession	NZ_CP065431
Coordinates	1282184..1282888 (-)	Length	234 a.a.
NCBI ID	WP_004298854.1	Uniprot ID	A0A0K2E6P6
Organism	Streptococcus suis strain YP20190405
Function	repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1277184..1287888

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I5W22_RS06275 (I5W22_06275)	-	1278059..1278808 (-)	750	WP_012027298.1	ATP-binding cassette domain-containing protein	-
I5W22_RS06280 (I5W22_06280)	-	1278971..1279513 (-)	543	WP_012027299.1	ATP-binding cassette domain-containing protein	-
I5W22_RS06285 (I5W22_06285)	-	1279621..1279776 (-)	156	WP_014636649.1	hypothetical protein	-
I5W22_RS06290 (I5W22_06290)	vicX	1280032..1280835 (-)	804	WP_012027300.1	MBL fold metallo-hydrolase	Regulator
I5W22_RS06295 (I5W22_06295)	micB	1280842..1282191 (-)	1350	WP_012027301.1	cell wall metabolism sensor histidine kinase VicK	Regulator
I5W22_RS06300 (I5W22_06300)	micA	1282184..1282888 (-)	705	WP_004298854.1	response regulator YycF	Regulator
I5W22_RS06305 (I5W22_06305)	-	1283082..1283843 (+)	762	WP_012027304.1	amino acid ABC transporter ATP-binding protein	-
I5W22_RS06310 (I5W22_06310)	-	1283854..1284693 (+)	840	WP_012027305.1	transporter substrate-binding domain-containing protein	-
I5W22_RS06315 (I5W22_06315)	-	1284708..1285406 (+)	699	WP_012028333.1	amino acid ABC transporter permease	-
I5W22_RS06320 (I5W22_06320)	-	1285421..1286080 (+)	660	WP_002935828.1	amino acid ABC transporter permease	-

Sequence

Protein

Download Length: 234 a.a. Molecular weight: 26781.77 Da Isoelectric Point: 4.8957

                                >NTDB_id=509575 I5W22_RS06300 WP_004298854.1 1282184..1282888(-) (micA) [Streptococcus suis strain YP20190405]

MKKILIVDDEKPISDIIKFNMTREGYEVVTAFDGREALEVFEAEFPDIVILDLMLPELDGLEVARTIRKTSNVPILMLSA

KDSEFDKVIGLEIGADDYVTKPFSNRELQARVKALLRRSELAETQTNIESTGTPELVIGDLVILPDAFVAKKHGKELELT

HREFELLHHLAKHLGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYFIKGND

Nucleotide

Download Length: 705 bp

                                >NTDB_id=509575 I5W22_RS06300 WP_004298854.1 1282184..1282888(-) (micA) [Streptococcus suis strain YP20190405]

ATGAAAAAAATATTAATTGTAGATGATGAAAAACCAATCTCAGATATTATTAAGTTTAATATGACGCGTGAGGGATATGA

AGTTGTGACAGCTTTCGATGGACGTGAAGCCTTGGAAGTATTTGAGGCTGAGTTTCCTGACATTGTCATTTTGGACTTGA

TGTTGCCAGAATTGGACGGACTAGAGGTTGCTCGAACGATTCGTAAGACCAGCAATGTTCCAATCTTGATGTTATCTGCT

AAAGATAGCGAATTTGATAAGGTTATCGGGCTTGAAATAGGGGCGGATGATTATGTGACCAAGCCCTTCTCTAATCGCGA

ATTACAGGCGCGTGTTAAGGCTCTTCTTCGTCGTAGTGAATTGGCAGAGACGCAGACAAATATTGAGTCAACAGGAACTC

CAGAGTTGGTGATTGGCGATTTGGTCATTCTGCCTGATGCGTTTGTTGCTAAGAAGCATGGTAAAGAGCTGGAGCTGACC

CATCGTGAGTTTGAATTGCTCCACCATCTGGCCAAACACTTAGGTCAGGTTATGACTCGAGAACATCTATTGGAAACAGT

TTGGGGTTATGATTACTTTGGTGATGTCCGCACGGTGGATGTAACGATTCGTCGTCTGCGTGAGAAAATTGAAGATACAC

CAAGCAGACCAGAATACATTCTTACTCGTCGCGGAGTGGGATATTTTATAAAAGGAAATGATTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)

Response regulator receiver domain (Response_reg)

(4-112)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A0K2E6P6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
micA	Streptococcus pneumoniae Cp1015	81.974	99.573	0.816
vicR	Streptococcus mutans UA159	80.426	100	0.808
covR	Lactococcus lactis subsp. lactis strain DGCC12653	44.783	98.291	0.44
covR	Streptococcus salivarius strain HSISS4	43.723	98.718	0.432
scnR	Streptococcus mutans UA159	38.095	98.718	0.376

Detailed information NTG0509575