Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   ST1A_RS01040 Genome accession   NZ_CP065384
Coordinates   182227..182976 (+) Length   249 a.a.
NCBI ID   WP_011225365.1    Uniprot ID   Q5M699
Organism   Streptococcus thermophilus strain 1A     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 177227..187976
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ST1A_RS01010 (ST1A_01010) - 177802..177972 (+) 171 WP_023909348.1 hypothetical protein -
  ST1A_RS01015 (ST1A_01015) - 178059..178166 (+) 108 WP_002949251.1 LPXTG cell wall anchor domain-containing protein -
  ST1A_RS01020 (ST1A_01020) - 178253..178993 (-) 741 WP_002949253.1 amino acid ABC transporter ATP-binding protein -
  ST1A_RS01025 (ST1A_01025) - 178993..180543 (-) 1551 WP_011680665.1 ABC transporter substrate-binding protein/permease -
  ST1A_RS01030 (ST1A_01030) - 180746..181600 (+) 855 WP_023909349.1 undecaprenyl-diphosphate phosphatase -
  ST1A_RS01035 (ST1A_01035) - 181746..181961 (-) 216 WP_011226805.1 DUF3021 family protein -
  ST1A_RS01040 (ST1A_01040) mecA 182227..182976 (+) 750 WP_011225365.1 adaptor protein MecA Regulator
  ST1A_RS01045 (ST1A_01045) - 182980..184137 (+) 1158 WP_014621088.1 MraY family glycosyltransferase -
  ST1A_RS01050 (ST1A_01050) sufC 184298..185068 (+) 771 WP_002947634.1 Fe-S cluster assembly ATPase SufC -
  ST1A_RS01055 (ST1A_01055) sufD 185105..186367 (+) 1263 WP_011680669.1 Fe-S cluster assembly protein SufD -
  ST1A_RS01060 (ST1A_01060) - 186421..187653 (+) 1233 WP_046206385.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29157.70 Da        Isoelectric Point: 4.0659

>NTDB_id=509065 ST1A_RS01040 WP_011225365.1 182227..182976(+) (mecA) [Streptococcus thermophilus strain 1A]
MEMKQINETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEALDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAF
SDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL
PVLQATKWS

Nucleotide


Download         Length: 750 bp        

>NTDB_id=509065 ST1A_RS01040 WP_011225365.1 182227..182976(+) (mecA) [Streptococcus thermophilus strain 1A]
ATGGAAATGAAACAAATAAACGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT
GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT
TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT
AAGGAAGCCCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT
TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG
ATGAGACTATGACAGAGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC
TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAATTTTATAAACTTGG
TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q5M699

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus thermophilus LMG 18311

100

100

1
  mecA Streptococcus thermophilus LMD-9

99.197

100

0.992
  mecA Streptococcus mutans UA159

57.377

97.992

0.562
  mecA Streptococcus pneumoniae Rx1

46.185

100

0.462
  mecA Streptococcus pneumoniae D39

46.185

100

0.462
  mecA Streptococcus pneumoniae R6

46.185

100

0.462
  mecA Streptococcus pneumoniae TIGR4

46.185

100

0.462