Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   I2438_RS08395 Genome accession   NZ_CP065190
Coordinates   1700801..1702696 (-) Length   631 a.a.
NCBI ID   WP_021321068.1    Uniprot ID   -
Organism   Streptococcus equi subsp. zooepidemicus strain SEZ36     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1695801..1707696
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I2438_RS08370 (HCFMJIKG_01664) - 1696544..1696906 (-) 363 WP_012516140.1 S1 RNA-binding domain-containing protein -
  I2438_RS08375 (HCFMJIKG_01665) - 1696906..1698306 (-) 1401 WP_021321065.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  I2438_RS08380 (HCFMJIKG_01666) - 1698340..1698981 (-) 642 WP_021321066.1 response regulator -
  I2438_RS08385 (HCFMJIKG_01667) - 1698974..1699978 (-) 1005 WP_012516143.1 sensor histidine kinase -
  I2438_RS08390 (HCFMJIKG_01668) liaF 1699975..1700667 (-) 693 WP_021321067.1 cell wall-active antibiotics response protein LiaF -
  I2438_RS08395 (HCFMJIKG_01669) pknB 1700801..1702696 (-) 1896 WP_021321068.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  I2438_RS08400 (HCFMJIKG_01670) - 1702693..1703433 (-) 741 WP_012516146.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  I2438_RS08405 (HCFMJIKG_01671) rsmB 1703471..1704793 (-) 1323 WP_037584314.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  I2438_RS08410 (HCFMJIKG_01672) fmt 1704783..1705718 (-) 936 WP_021321070.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 631 a.a.        Molecular weight: 68580.79 Da        Isoelectric Point: 6.6073

>NTDB_id=507781 I2438_RS08395 WP_021321068.1 1700801..1702696(-) (pknB) [Streptococcus equi subsp. zooepidemicus strain SEZ36]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGSDLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKSGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENPNVP
QALENVVIRATAKKLSDRYRSTFEMSRDLMTALSYNRSRERKVVFDDVESTKPLPKVTPIPVTAPKVSNASQASAAADAR
LEQTSQMDTLQKPQKKKKNGRFLGTLLKILFSFFVVGVALFAYLVLTKPTTVKVPDVTGSSLNAAKQVLEEAGLKVGKVH
QIESDTVSEDQVVKTNPQAGSAKRKGSSVDLYLSIGNKGFEMENYKGQDYQDVMTSLTETYGVPKSKIKIERIVTNEYPE
NTVISQSPSAGEKFNPAGKSKITLSVAVGDTVIMPMVTEYSYADAVNTLTALGIDAARIKAYVPSSSSPTGFVQVSSPSS
KAIVSGQTPYYGTQISLSEKGDISLYLYPEETRASSSSSSSDTSAPNPSAGDTTDSSSHTELGQNDAVTTP

Nucleotide


Download         Length: 1896 bp        

>NTDB_id=507781 I2438_RS08395 WP_021321068.1 1700801..1702696(-) (pknB) [Streptococcus equi subsp. zooepidemicus strain SEZ36]
ATGATTCAGATTGGCAAGCTATTTGCTGGTCGTTATCGCATTCTAAAATCTATAGGCCGCGGTGGTATGGCGGATGTTTA
TTTAGCAAACGATTTGATTCTGGATAATGAGGACGTTGCCATTAAGGTCTTGCGGACCAATTATCAAACAGATCAGGTTG
CTGTTGCGCGTTTTCAAAGAGAAGCGCGAGCCATGGCTGAATTAAATCACCCCAATATTGTTGCCATTCGGGATATAGGC
GAGGAAGACGGACAGCAATTTTTAGTAATGGAATATGTTGATGGCTCTGATTTGAAAAAATACATTCAGGATCATGCGCC
ATTATCTAACAATGAGGTGGTGAGAATCATGGAAGAGGTTCTTTCTGCCATGACTCTGGCCCACCAAAAAGGAATTGTTC
ACAGGGATTTAAAGCCTCAAAACATTCTTTTGACCAAATCAGGTGTTGTTAAGGTTACAGATTTTGGGATTGCTGTTGCC
TTTGCAGAGACCAGTCTAACCCAGACAAATTCTATGCTAGGAAGTGTGCATTACCTCTCACCTGAGCAAGCGCGTGGTTC
TAAAGCGACGATTCAAAGTGATATTTACGCGATGGGAATTATGCTCTTTGAAATGCTAACAGGGCATATTCCTTATGATG
GCGATAGCGCTGTGACGATTGCTTTGCAGCATTTTCAAAAGCCGCTGCCCTCTATCATTGATGAAAATCCTAATGTGCCT
CAAGCCTTGGAGAACGTCGTTATTCGGGCTACTGCCAAAAAGCTAAGTGACCGTTATCGCTCGACCTTTGAGATGAGCAG
GGATTTGATGACAGCCCTTAGCTATAACCGCAGTCGTGAGCGTAAGGTTGTCTTTGATGATGTCGAAAGCACAAAGCCCT
TGCCAAAGGTAACACCGATTCCTGTAACAGCACCTAAGGTATCAAATGCTAGTCAGGCATCTGCGGCAGCTGATGCTAGA
CTTGAGCAGACTAGCCAGATGGATACTCTGCAAAAGCCTCAAAAAAAGAAAAAAAATGGGCGTTTTCTAGGAACACTCTT
AAAAATCTTGTTTTCCTTTTTTGTTGTTGGTGTGGCTCTTTTTGCTTATTTGGTCTTGACCAAGCCAACTACGGTTAAGG
TTCCTGATGTGACAGGCTCTAGTCTCAATGCTGCCAAGCAGGTCTTGGAGGAGGCGGGACTAAAGGTCGGTAAGGTCCAT
CAGATTGAAAGTGACACAGTTAGTGAGGATCAGGTGGTTAAGACAAATCCTCAAGCTGGCTCAGCTAAGCGAAAAGGCTC
CAGCGTTGACCTTTACCTTTCGATCGGAAATAAAGGCTTTGAGATGGAAAATTATAAGGGACAGGATTATCAAGATGTGA
TGACCAGTCTGACTGAGACCTATGGCGTACCAAAGTCAAAAATCAAGATTGAGCGTATCGTGACAAATGAATACCCTGAA
AACACCGTTATTAGCCAGTCTCCAAGCGCAGGAGAAAAATTTAACCCAGCTGGTAAATCTAAGATTACTCTCAGTGTAGC
AGTGGGTGATACGGTCATCATGCCAATGGTAACTGAGTACAGCTATGCAGACGCAGTCAATACACTAACAGCCCTAGGAA
TTGATGCCGCAAGAATCAAGGCCTATGTACCAAGCTCCAGCTCTCCGACAGGCTTTGTGCAGGTGAGCTCCCCAAGCTCA
AAGGCGATTGTCAGTGGGCAGACACCGTATTATGGTACCCAGATTAGCCTTTCTGAAAAGGGTGATATTAGCCTCTACCT
CTACCCTGAGGAGACACGTGCATCAAGCAGCTCATCGAGCTCTGATACCTCGGCTCCTAATCCATCAGCTGGAGATACAA
CAGACTCAAGCAGTCATACCGAATTAGGTCAAAATGACGCTGTTACAACACCATAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-232)

PASTA domain (PASTA)

(372-434)

PASTA domain (PASTA)

(512-588)

PASTA domain (PASTA)

(441-506)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

65.714

94.295

0.62
  stkP/pknB Streptococcus salivarius strain HSISS4

62.415

93.185

0.582
  stkP Streptococcus pneumoniae TIGR4

57.558

81.775

0.471
  stkP Streptococcus pneumoniae D39

57.171

81.775

0.468
  stkP Streptococcus pneumoniae R6

57.171

81.775

0.468
  stkP Streptococcus pneumoniae Rx1

56.977

81.775

0.466