Detailed information    

insolico Bioinformatically predicted

Overview

Name   comFA/cflA   Type   Machinery gene
Locus tag   SANR_RS02235 Genome accession   NC_022239
Coordinates   434985..436286 (+) Length   433 a.a.
NCBI ID   WP_003035191.1    Uniprot ID   I0SHA2
Organism   Streptococcus anginosus C238     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 429985..441286
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SANR_RS11065 - 431157..432035 (-) 879 Protein_400 ISAs1 family transposase -
  SANR_RS11070 - 432212..432481 (-) 270 Protein_401 IS30 family transposase -
  SANR_RS02220 - 432586..433247 (-) 662 Protein_402 ISL3 family transposase -
  SANR_RS02225 (SANR_0436) cysK 433264..434193 (-) 930 WP_003035221.1 cysteine synthase A -
  SANR_RS02230 (SANR_0437) - 434293..434928 (-) 636 WP_003035211.1 YigZ family protein -
  SANR_RS02235 (SANR_0438) comFA/cflA 434985..436286 (+) 1302 WP_003035191.1 DEAD/DEAH box helicase Machinery gene
  SANR_RS02240 (SANR_0439) comFC/cflB 436283..436948 (+) 666 WP_003035196.1 ComF family protein Machinery gene
  SANR_RS02245 (SANR_0440) hpf 437027..437569 (+) 543 WP_003035226.1 ribosome hibernation-promoting factor, HPF/YfiA family -
  SANR_RS02250 (SANR_0441) rsmD 437757..438305 (+) 549 WP_195190375.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  SANR_RS02255 (SANR_0442) coaD 438295..438792 (+) 498 WP_003025749.1 pantetheine-phosphate adenylyltransferase -
  SANR_RS02260 (SANR_0443) sepM 438773..439828 (+) 1056 WP_003035215.1 SepM family pheromone-processing serine protease Regulator
  SANR_RS02265 (SANR_0444) - 439966..440529 (+) 564 WP_003035207.1 YutD family protein -

Sequence

Protein


Download         Length: 433 a.a.        Molecular weight: 49236.08 Da        Isoelectric Point: 8.8298

>NTDB_id=50716 SANR_RS02235 WP_003035191.1 434985..436286(+) (comFA/cflA) [Streptococcus anginosus C238]
MTELQDCLGRIFAKNQLSPELQLQAQSLAGMVEEKRKLSCNRCGQAVDKEKYQLPISAYYCRFCLFLGRIRSDEHLYYFS
QEEFPKANVLKWQGKLTEFQAKVSQGLVEAVTKRKDSLVHAVTGAGKTEMIYQVVAQVINQGGAVCLASPRIDVCLELYR
RLKVDFTCDISLLHGESEAYSRSPLVIATTHQLLKFYQAFDLLIVDEVDAFPYVDNPMLYHAVHQAVKVEGTKIFLTATS
TDELDKKVAKGELTRLSLPRRFHGNPLIVPRKVWLADFQKYLGQKKLVTKLRQFIQKQRKTGFPLLIFASEIKRGQEFAE
VLQNNFPNEKVGFVASTTENRLEIVEKFRQKEITILVTTTILERGVTFPCVDVFVVEANHRLFSRSALVQIAGRVGRSMD
RPTGELIFFHDGTTMAIEKAIKEIQEMNQEAGL

Nucleotide


Download         Length: 1302 bp        

>NTDB_id=50716 SANR_RS02235 WP_003035191.1 434985..436286(+) (comFA/cflA) [Streptococcus anginosus C238]
ATGACAGAATTACAAGATTGTTTAGGTCGCATTTTTGCCAAAAATCAACTGTCACCAGAATTGCAATTGCAAGCACAAAG
CTTAGCTGGAATGGTAGAAGAAAAAAGGAAGTTAAGCTGCAATCGCTGTGGGCAAGCAGTTGATAAAGAAAAATACCAAC
TGCCCATAAGTGCTTATTATTGCAGGTTTTGCTTGTTCTTAGGAAGGATCAGAAGCGATGAACATCTTTACTATTTTTCA
CAGGAAGAGTTTCCTAAAGCGAATGTCTTGAAATGGCAAGGAAAGTTGACAGAATTTCAAGCTAAGGTTTCTCAAGGACT
TGTAGAGGCGGTTACCAAACGCAAAGATAGCTTGGTTCACGCAGTCACGGGAGCCGGAAAGACGGAAATGATCTATCAAG
TGGTGGCACAAGTCATCAATCAAGGCGGAGCCGTCTGCTTAGCTAGCCCCAGAATTGATGTCTGCTTAGAACTTTATCGC
AGACTGAAAGTAGATTTTACCTGTGATATTTCACTCCTGCACGGCGAATCAGAAGCATATTCCCGCAGTCCTCTCGTGAT
TGCCACCACACATCAGCTTCTCAAATTTTATCAAGCATTTGATCTTCTTATCGTTGATGAAGTAGATGCCTTTCCTTATG
TGGACAATCCGATGCTTTATCATGCAGTTCATCAGGCAGTCAAAGTAGAGGGGACGAAGATTTTCTTAACAGCAACTTCC
ACAGATGAGCTGGATAAAAAAGTGGCTAAAGGAGAATTAACTCGTTTGAGTCTACCCAGACGTTTTCATGGGAATCCTTT
AATTGTTCCTCGAAAAGTTTGGCTGGCGGATTTTCAAAAATATCTTGGTCAAAAGAAGCTAGTTACCAAGCTAAGGCAGT
TTATTCAAAAGCAAAGAAAAACAGGTTTTCCTCTTCTCATTTTTGCTTCTGAGATTAAAAGAGGACAAGAATTTGCAGAG
GTTCTCCAAAACAATTTCCCTAATGAAAAAGTTGGCTTTGTAGCCTCGACGACTGAAAATCGACTAGAAATTGTAGAGAA
ATTTCGTCAAAAAGAAATCACGATTTTGGTAACGACGACGATTTTGGAGCGTGGGGTGACCTTTCCTTGTGTAGATGTTT
TCGTGGTGGAAGCCAACCACCGTCTGTTTAGTCGCAGCGCTCTGGTACAAATCGCTGGACGCGTCGGTCGCAGTATGGAT
CGACCGACAGGCGAGTTAATCTTTTTTCATGACGGTACAACTATGGCGATAGAAAAAGCGATTAAAGAAATTCAGGAGAT
GAATCAGGAGGCCGGTCTATGA

Domains

Predicted by InterProScan.

DEAD/DEAH box helicase (DEAD)

(108-245)

Helicase conserved C-terminal domain (Helicase_C)

(290-397)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I0SHA2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comFA/cflA Streptococcus pneumoniae Rx1

70.327

98.845

0.695
  comFA/cflA Streptococcus pneumoniae D39

70.327

98.845

0.695
  comFA/cflA Streptococcus pneumoniae R6

70.327

98.845

0.695
  comFA/cflA Streptococcus mitis NCTC 12261

70.657

98.383

0.695
  comFA/cflA Streptococcus pneumoniae TIGR4

70.093

98.845

0.693
  comFA/cflA Streptococcus mitis SK321

70.188

98.383

0.691
  comFA Lactococcus lactis subsp. cremoris KW2

55.668

91.686

0.51
  comFA Latilactobacillus sakei subsp. sakei 23K

41.353

92.148

0.381
  comFA Bacillus subtilis subsp. subtilis str. 168

40.148

93.764

0.376

Multiple sequence alignment