Detailed information NTG0050718

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: SANR_RS02260
• Genome accession: NC_022239
• Coordinates: 438773..439828 (+)
• Length: 351 a.a.
• NCBI ID: WP_003035215.1
• Uniprot ID: I0SHB2
• Organism: Streptococcus anginosus C238
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 433773..444828

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SANR_RS02230 (SANR_0437)	-	434293..434928 (-)	636	WP_003035211.1	YigZ family protein	-
SANR_RS02235 (SANR_0438)	comFA/cflA	434985..436286 (+)	1302	WP_003035191.1	DEAD/DEAH box helicase	Machinery gene
SANR_RS02240 (SANR_0439)	comFC/cflB	436283..436948 (+)	666	WP_003035196.1	ComF family protein	Machinery gene
SANR_RS02245 (SANR_0440)	hpf	437027..437569 (+)	543	WP_003035226.1	ribosome hibernation-promoting factor, HPF/YfiA family	-
SANR_RS02250 (SANR_0441)	rsmD	437757..438305 (+)	549	WP_195190375.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
SANR_RS02255 (SANR_0442)	coaD	438295..438792 (+)	498	WP_003025749.1	pantetheine-phosphate adenylyltransferase	-
SANR_RS02260 (SANR_0443)	sepM	438773..439828 (+)	1056	WP_003035215.1	SepM family pheromone-processing serine protease	Regulator
SANR_RS02265 (SANR_0444)	-	439966..440529 (+)	564	WP_003035207.1	YutD family protein	-
SANR_RS02270 (SANR_0445)	rlmN	440563..441646 (+)	1084	Protein_412	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
SANR_RS02275 (SANR_0446)	-	441639..442169 (+)	531	WP_003035190.1	VanZ family protein	-
SANR_RS11075	-	442377..443728 (+)	1352	WP_148290568.1	IS3 family transposase	-

Sequence

Protein

• Length: 351 a.a.
• Molecular weight: 38352.32 Da
• Isoelectric Point: 10.1906

>NTDB_id=50718 SANR_RS02260 WP_003035215.1 438773..439828(+) (sepM) [Streptococcus anginosus C238]
MEKPRNKFKKWPIIAVVGLILLFLSFVVPLPYYIEVPGGAADVRQVLRVDNKEDKEKGSYNFVTVGIQHATFAHLVYAWL
TPFTDIYSAKDLTGGTSDKEYMRINQFYMETSQNLAKYQGLKKAGKDITLKYLGVYVLQVTKNSTFKGILNIADTVTGVN
DKTFNSSKELIDYVGAQKIGSKVKVNYVEDGQKKSATGKIIKLENGKNGIGISLIDRTEVTSNTPIEFSTAGIGGPSAGL
MFSLAIYTQIADPTLRDGRNIAGTGSIDREGKVGDIGGIDKKVVSAAKNGAEIFFAPNNPVTKEVKKSNPKAKTNYETAL
AAAKKIKTKMKIIPVKTLQDAIDYLKSTKKS

Nucleotide

• Length: 1056 bp

>NTDB_id=50718 SANR_RS02260 WP_003035215.1 438773..439828(+) (sepM) [Streptococcus anginosus C238]
ATGGAAAAACCAAGAAATAAATTTAAAAAATGGCCGATAATTGCAGTAGTAGGGCTGATTTTGCTTTTCTTATCTTTTGT
AGTTCCCTTGCCTTATTATATTGAGGTGCCAGGTGGTGCAGCGGATGTCCGTCAGGTATTGCGCGTGGACAACAAAGAAG
ATAAGGAAAAAGGTTCTTATAATTTTGTAACGGTTGGGATTCAGCATGCGACCTTCGCTCATTTGGTTTATGCTTGGCTG
ACTCCTTTTACAGATATTTATTCGGCGAAGGATTTGACTGGCGGAACTTCTGATAAAGAATACATGCGGATCAATCAGTT
TTATATGGAAACGTCGCAAAACCTAGCTAAATACCAAGGCTTGAAAAAAGCTGGCAAAGACATTACTCTGAAATATCTAG
GGGTTTACGTCTTGCAAGTCACAAAGAATTCTACTTTTAAAGGTATTTTAAATATTGCAGATACCGTGACAGGTGTGAAT
GATAAGACTTTCAATAGTTCAAAAGAATTGATAGACTATGTCGGAGCGCAAAAGATTGGCAGCAAGGTCAAGGTGAACTA
TGTAGAAGACGGTCAGAAGAAATCTGCTACAGGTAAAATTATTAAACTTGAAAATGGAAAAAACGGGATTGGCATTAGCT
TGATTGACCGAACAGAAGTCACAAGTAACACACCAATTGAATTTTCAACTGCCGGTATTGGTGGACCAAGTGCGGGCTTG
ATGTTTAGTTTGGCAATTTATACGCAAATTGCAGATCCAACATTGAGAGACGGCAGAAATATTGCTGGGACGGGCTCAAT
TGACCGCGAAGGAAAAGTTGGCGACATTGGTGGGATTGACAAAAAAGTTGTTTCAGCAGCTAAAAATGGCGCAGAAATTT
TCTTTGCGCCAAATAATCCAGTCACCAAGGAAGTGAAAAAATCCAATCCTAAAGCGAAAACAAACTATGAGACAGCTTTG
GCAGCTGCTAAAAAAATTAAAACTAAAATGAAAATTATACCTGTCAAGACCTTGCAAGACGCAATTGATTACCTCAAGAG
CACAAAAAAGTCGTAA

Domains

Predicted by InterProScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (234-307)

• PDZ domain (PDZ_2) (133-197)

3D structure

• AlphaFold DB: I0SHB2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	64.223	97.151	0.624