Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   IUH68_RS01140 Genome accession   NZ_CP064406
Coordinates   229123..230412 (-) Length   429 a.a.
NCBI ID   WP_058128852.1    Uniprot ID   A0A2G0CWQ6
Organism   Enterococcus faecium strain PR05720-3     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 224123..235412
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IUH68_RS01110 (IUH68_01110) - 224524..225471 (-) 948 WP_002289860.1 glycosyltransferase family 2 protein -
  IUH68_RS01115 (IUH68_01115) - 225694..226044 (-) 351 WP_002289862.1 PepSY domain-containing protein -
  IUH68_RS01120 (IUH68_01120) pepA 226244..227323 (+) 1080 WP_002294156.1 glutamyl aminopeptidase -
  IUH68_RS01125 (IUH68_01125) - 227466..227786 (+) 321 WP_002287837.1 thioredoxin family protein -
  IUH68_RS01130 (IUH68_01130) - 227808..228272 (+) 465 WP_038809452.1 universal stress protein -
  IUH68_RS01135 (IUH68_01135) ytpR 228479..229084 (+) 606 WP_002294153.1 YtpR family tRNA-binding protein -
  IUH68_RS01140 (IUH68_01140) htrA 229123..230412 (-) 1290 WP_058128852.1 trypsin-like peptidase domain-containing protein Regulator
  IUH68_RS01145 (IUH68_01145) rlmH 230841..231320 (+) 480 WP_002287841.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  IUH68_RS01150 (IUH68_01150) - 231523..232074 (+) 552 WP_002299296.1 PD-(D/E)XK nuclease family protein -
  IUH68_RS01155 (IUH68_01155) - 232145..233314 (+) 1170 Protein_230 IS256 family transposase -
  IUH68_RS01160 (IUH68_01160) - 233424..234602 (-) 1179 WP_002330719.1 IS256-like element ISEfm2 family transposase -

Sequence

Protein


Download         Length: 429 a.a.        Molecular weight: 44907.90 Da        Isoelectric Point: 4.5943

>NTDB_id=501887 IUH68_RS01140 WP_058128852.1 229123..230412(-) (htrA) [Enterococcus faecium strain PR05720-3]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSHNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1290 bp        

>NTDB_id=501887 IUH68_RS01140 WP_058128852.1 229123..230412(-) (htrA) [Enterococcus faecium strain PR05720-3]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTAGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAGAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCATAACCAATCAAGCGGTTTTGGCGGACTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACGAATAATCACGTAGTAGATGGCCAGCAAGGTCTTGAAGTCTTGATGAAAGAC
GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGT
CGAAACAGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAGCCTGCGATTGCGATTGGTTCCCCACTAGGAT
CTGAATATGCAAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTGACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTTAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(10-417)

PDZ domain (PDZ_2)

(317-414)

Trypsin-like peptidase domain (Trypsin_2)

(127-272)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2G0CWQ6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

54.569

91.841

0.501
  htrA Streptococcus mutans UA159

59.887

82.517

0.494
  htrA Streptococcus mitis NCTC 12261

52.778

92.308

0.487
  htrA Streptococcus pneumoniae TIGR4

59.05

78.555

0.464
  htrA Streptococcus pneumoniae Rx1

59.05

78.555

0.464
  htrA Streptococcus pneumoniae D39

59.05

78.555

0.464
  htrA Streptococcus pneumoniae R6

59.05

78.555

0.464