NTDB

Overview

Name	dprA	Type	Machinery gene
Locus tag	A7A18_RS18175	Genome accession	NZ_CP076262
Coordinates	3704050..3705174 (-)	Length	374 a.a.
NCBI ID	WP_000228535.1	Uniprot ID	B7LHY7
Organism	Escherichia coli strain 0-4
Function	ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 3699050..3710174

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A7A18_RS18145 (A7A18_18105)	yrdA	3700850..3701404 (+)	555	WP_001286216.1	gamma carbonic anhydrase family protein	-
A7A18_RS18150 (A7A18_18110)	yrdB	3701380..3701637 (-)	258	WP_001070603.1	DUF1488 domain-containing protein	-
A7A18_RS18155 (A7A18_18115)	aroE	3701634..3702452 (-)	819	WP_000451211.1	shikimate dehydrogenase	-
A7A18_RS18160 (A7A18_18120)	tsaC	3702457..3703029 (-)	573	WP_001297709.1	L-threonylcarbamoyladenylate synthase type 1 TsaC	-
A7A18_RS18165 (A7A18_18125)	yrdD	3703034..3703576 (-)	543	WP_001129719.1	type I DNA topoisomerase	-
A7A18_RS18170 (A7A18_18130)	smg	3703605..3704078 (-)	474	WP_000460672.1	DUF494 family protein Smg	-
A7A18_RS18175 (A7A18_18135)	dprA	3704050..3705174 (-)	1125	WP_000228535.1	DNA-protecting protein DprA	Machinery gene
A7A18_RS18180 (A7A18_18140)	def	3705304..3705813 (+)	510	WP_000114984.1	peptide deformylase	-
A7A18_RS18185 (A7A18_18145)	fmt	3705828..3706775 (+)	948	WP_000004454.1	methionyl-tRNA formyltransferase	-
A7A18_RS18190 (A7A18_18150)	rsmB	3706821..3708110 (+)	1290	WP_000744779.1	16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB	-
A7A18_RS18195 (A7A18_18155)	trkA	3708132..3709508 (+)	1377	WP_000691382.1	Trk system potassium transporter TrkA	-
A7A18_RS18200 (A7A18_18160)	mscL	3709638..3710048 (+)	411	WP_000022442.1	large-conductance mechanosensitive channel protein MscL	-

Sequence

Protein

Download Length: 374 a.a. Molecular weight: 40954.92 Da Isoelectric Point: 6.3122

                                >NTDB_id=501205 A7A18_RS18175 WP_000228535.1 3704050..3705174(-) (dprA) [Escherichia coli strain 0-4]

MVDTEIWLRLMSISSLYGDDMVRIAHWLAKQSQIDAVGLQQTGLTLRQAQRFLSFPRKSIESSLCWLEQPNHHLIPADSE

FYPPQLLVTTDYPGALFVEGELHALHSFQLAVVGSRAHSWYGERWGRLFCETLATRGVTITSGLARGIDGVAHKAALQVN

GVSIAVLGNGLNTIHPRRHARLAASLLEHGGALVSEFPLDVPPLAYNFPRRNRIISGLSKGVLVVEAALRSGSLVTARCA

LEQGREVFALPGPIGNPGSEGPHWLIKQGAILVTEPEEILENLQFGLHWLPDAPENSFYSPDQQDVALPFPELLANVGDE

VTPVDVVAERAGQPVPEVVTQLLELELAGWIAAVPGGYVRLRRACHVRRTNVFV

Nucleotide

Download Length: 1125 bp

                                >NTDB_id=501205 A7A18_RS18175 WP_000228535.1 3704050..3705174(-) (dprA) [Escherichia coli strain 0-4]

ATGGTCGATACAGAAATTTGGCTGCGTTTAATGAGTATCAGCAGCTTGTACGGCGATGATATGGTCCGTATAGCTCACTG

GCTGGCAAAACAGTCGCAAATTGATGCGGTTGGATTGCAGCAAACAGGGCTTACATTGCGGCAGGCACAACGCTTTCTTT

CATTTCCGCGAAAGAGTATCGAAAGCTCACTTTGTTGGTTGGAGCAACCCAACCATCATTTAATCCCTGCGGACAGCGAA

TTTTATCCTCCTCAACTTCTGGTGACGACAGATTACCCCGGCGCACTGTTTGTTGAAGGAGAACTGCACGCGCTGCATTC

ATTTCAGCTTGCCGTAGTGGGGAGTCGGGCGCATTCATGGTATGGCGAGCGATGGGGACGGTTATTTTGCGAAACTCTGG

CGACGCGTGGAGTGACAATTACGAGTGGACTGGCGCGTGGAATCGATGGTGTGGCGCATAAAGCGGCCTTACAGGTAAAT

GGCGTCAGCATTGCTGTATTGGGGAATGGACTTAATACCATTCATCCCCGCCGCCATGCCCGACTGGCTGCCAGTCTGCT

TGAACATGGCGGAGCTCTCGTCTCGGAATTTCCCCTCGATGTTCCACCCCTTGCTTACAATTTCCCACGAAGAAATCGCA

TTATCAGTGGTCTAAGTAAAGGTGTACTGGTGGTGGAAGCGGCTTTGCGCAGTGGTTCGCTGGTGACAGCACGTTGTGCG

CTTGAGCAGGGGCGTGAAGTTTTTGCCTTGCCAGGTCCAATAGGGAATCCGGGAAGCGAAGGGCCTCACTGGTTAATAAA

ACAAGGTGCGATTCTTGTGACGGAACCGGAAGAAATTCTGGAAAACTTGCAATTTGGATTGCACTGGTTGCCAGACGCCC

CTGAAAATTCATTTTATTCACCAGATCAGCAAGACGTGGCATTGCCATTTCCTGAGCTCCTGGCTAACGTAGGAGATGAG

GTAACACCTGTTGACGTCGTCGCTGAACGTGCCGGCCAACCTGTGCCAGAGGTAGTTACTCAACTACTCGAACTGGAGTT

AGCAGGATGGATCGCAGCTGTACCCGGCGGCTATGTCCGATTGAGGAGGGCATGCCATGTTCGACGTACTAATGTATTTG

TTTGA

Domains

Predicted by InterProScan.

DNA recombination-mediator protein A (DNA_processg_A)

(67-274)

DprA winged helix domain (WHD_DprA)

(312-357)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	B7LHY7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
dprA	Vibrio campbellii strain DS40M4	48.509	98.663	0.479
dprA	Vibrio cholerae O1 biovar El Tor strain E7946	44.865	98.93	0.444
dprA	Vibrio cholerae strain A1552	44.865	98.93	0.444
dprA	Haemophilus influenzae Rd KW20	45.401	90.107	0.409
dprA	Glaesserella parasuis strain SC1401	44.838	90.642	0.406
dprA	Legionella pneumophila strain ERS1305867	44.545	88.235	0.393

Detailed information NTG0501205