Detailed information NTG0500568

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: LacP0245_RS07465
• Genome accession: NZ_CP064299
• Coordinates: 1547305..1549497 (-)
• Length: 730 a.a.
• NCBI ID: WP_194959036.1
• Uniprot ID: -
• Organism: Lacticaseibacillus paracasei subsp. tolerans strain MGB0245
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1542305..1554497

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LacP0245_RS07435 (LacP0245_07435)	-	1542470..1542754 (-)	285	WP_003580845.1	bacteriocin immunity protein	-
LacP0245_RS07440 (LacP0245_07440)	-	1542948..1543244 (-)	297	WP_003588783.1	bacteriocin immunity protein	-
LacP0245_RS07445 (LacP0245_07445)	-	1543346..1544701 (-)	1356	WP_003567335.1	threonine/serine exporter ThrE family protein	-
LacP0245_RS07450 (LacP0245_07450)	-	1545007..1545318 (-)	312	WP_003580849.1	hypothetical protein	-
LacP0245_RS07455 (LacP0245_07455)	-	1545391..1545741 (-)	351	WP_003567340.1	hypothetical protein	-
LacP0245_RS07460 (LacP0245_07460)	-	1545915..1547294 (-)	1380	WP_003596059.1	bacteriocin secretion accessory protein	-
LacP0245_RS07465 (LacP0245_07465)	comA	1547305..1549497 (-)	2193	WP_194959036.1	peptide cleavage/export ABC transporter	Regulator
LacP0245_RS07470 (LacP0245_07470)	-	1549963..1550103 (-)	141	WP_016384130.1	bacteriocin-like peptide, LSEI_2386 family	-
LacP0245_RS07475 (LacP0245_07475)	-	1550294..1551592 (+)	1299	WP_016388367.1	GHKL domain-containing protein	-
LacP0245_RS07480 (LacP0245_07480)	-	1551597..1552403 (+)	807	WP_003567351.1	LytR/AlgR family response regulator transcription factor	-
LacP0245_RS07485 (LacP0245_07485)	-	1552765..1552962 (-)	198	WP_016388366.1	hypothetical protein	-
LacP0245_RS07490 (LacP0245_07490)	-	1553509..1553748 (+)	240	WP_003605974.1	hypothetical protein	-
LacP0245_RS07495 (LacP0245_07495)	-	1554008..1554181 (-)	174	WP_032675994.1	bacteriocin	-
LacP0245_RS07500 (LacP0245_07500)	-	1554216..1554404 (-)	189	WP_003567358.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-

Sequence

Protein

• Length: 730 a.a.
• Molecular weight: 81279.51 Da
• Isoelectric Point: 7.1059

>NTDB_id=500568 LacP0245_RS07465 WP_194959036.1 1547305..1549497(-) (comA) [Lacticaseibacillus paracasei subsp. tolerans strain MGB0245]
MIKYNLKLGQAQYYKRYYTPQVDERDCGVAALNMLLQFHGSDYSLAHLRQLAKTDQEGTTALGIVRAAQALHFETKAVKA
DMTLFDLDDVPYPFLVHVLKRGELLHYYVVFKATKDHILIGDPDPSVAMTWLPKERFAKEWSGVAIFIAPEPQYQPRKED
KGSLFAFVPILARQKGIIANIIVAAVLITLISIVGSYFLQSIIDTYIPNGMRTTLGMIASGLILAYVLQSVLTYGQNFLM
AVLGQRLSIDVILGYVRHLYELPMSFFSTRRTGEIVSRFSDANKIIDALANTIMTLFLDIWIVLILGIVLGIQNTTLFLV
SLIAVPCYLVIVFAFQRPFNRLNQETMESNAILSSSIIEDLNGIETIKSLTGEKVSYERVDREFVTYLKKSFNHTKADQL
QQAIKGLLKLVLNVVVLWIGASLVMANKMSLGQMLTFNALLAYFTNPLESIINLQPKLQMAKVANNRLNEVYLVESEFKE
QRSLNDRHLIDGAINVTDVSFKYGFGQDVLKQINLEIPENAKYTIVGMSGSGKSTLAKLLVGFYPVDTGKGKITFNGVPI
SDVDLTTLRQYIEYVPQDPFIFSGSVIENLTLGSRSNITEADIEAACSVAEIAGDISNLPQIWQTKLSESGSILSGGQKQ
RLAIARALLSPAKVLIFDESTSSLDTITERKIVDRLLAMTDRTIIFVAHRLTIAAKTEQIVVMDHGAIVEQGNHAELLAK
QGYYARLVSE

Nucleotide

• Length: 2193 bp

>NTDB_id=500568 LacP0245_RS07465 WP_194959036.1 1547305..1549497(-) (comA) [Lacticaseibacillus paracasei subsp. tolerans strain MGB0245]
ATGATCAAATACAACCTAAAGCTCGGCCAAGCACAGTATTACAAGCGTTACTACACGCCTCAGGTGGATGAGCGCGATTG
CGGGGTTGCGGCGCTTAATATGCTGCTGCAATTTCATGGCTCGGATTATTCGCTAGCGCATCTGCGACAGTTGGCGAAGA
CGGATCAGGAAGGAACAACAGCGTTAGGGATTGTCCGCGCTGCTCAGGCGCTTCATTTTGAAACCAAGGCTGTCAAGGCG
GATATGACGCTGTTTGATCTTGATGATGTTCCTTATCCGTTTCTTGTCCATGTTTTGAAGCGTGGCGAGTTGCTTCATTA
TTATGTCGTGTTTAAGGCGACAAAGGATCATATCTTGATTGGCGATCCTGATCCATCAGTAGCGATGACCTGGCTTCCCA
AAGAGCGCTTTGCGAAGGAGTGGTCGGGGGTCGCTATTTTTATTGCGCCAGAACCGCAATATCAACCACGCAAAGAGGAC
AAAGGCAGTCTCTTTGCGTTTGTGCCGATACTAGCGCGACAAAAAGGGATCATTGCCAATATTATTGTCGCCGCTGTGTT
GATCACGTTGATTAGTATTGTCGGGTCTTATTTTCTTCAGTCGATTATTGATACTTATATTCCAAACGGGATGCGCACAA
CTTTGGGAATGATTGCCAGTGGTCTCATCCTTGCTTATGTCCTGCAGTCGGTTTTAACCTATGGGCAAAATTTTTTGATG
GCTGTTTTAGGACAGCGTTTGTCGATTGATGTCATTTTGGGTTACGTTAGGCATCTTTATGAATTACCTATGTCCTTCTT
TTCCACGCGTCGGACTGGGGAGATTGTATCGCGGTTTTCCGATGCTAATAAGATTATTGATGCGCTGGCAAACACGATTA
TGACCTTGTTTCTTGATATTTGGATTGTCTTAATTTTAGGGATCGTGTTAGGCATTCAAAACACCACCTTATTCTTAGTG
TCTTTAATTGCTGTGCCTTGTTATTTGGTGATTGTGTTCGCTTTTCAGCGGCCATTTAATCGACTGAATCAAGAGACGAT
GGAAAGCAATGCCATTTTGAGTTCATCCATTATCGAGGATTTGAACGGGATTGAGACGATTAAATCACTGACCGGTGAGA
AAGTCAGTTATGAACGGGTTGACCGTGAATTCGTCACGTATTTGAAAAAGTCGTTCAATCATACAAAAGCTGATCAACTG
CAGCAGGCGATCAAGGGACTGCTGAAGTTGGTTTTGAATGTGGTCGTGCTGTGGATTGGTGCGAGTTTGGTGATGGCTAA
CAAGATGAGTCTAGGACAGATGCTGACGTTCAATGCGTTGTTGGCATATTTCACTAATCCGTTAGAAAGCATCATTAATT
TGCAACCAAAATTGCAAATGGCCAAAGTCGCGAATAACCGACTGAATGAAGTGTATTTGGTTGAATCGGAGTTTAAAGAA
CAGCGAAGTTTGAATGATCGGCATTTAATTGATGGCGCCATCAATGTTACCGATGTGTCCTTTAAGTATGGTTTTGGGCA
AGATGTTTTGAAGCAAATCAATCTTGAAATCCCAGAGAATGCCAAATACACCATTGTCGGCATGAGTGGATCAGGGAAAT
CGACCTTAGCCAAGTTGCTAGTAGGTTTCTATCCAGTGGACACTGGCAAAGGGAAAATCACATTTAATGGGGTTCCAATC
AGTGATGTTGATCTGACAACGTTACGACAATATATCGAGTATGTACCACAAGATCCGTTTATTTTTTCTGGCTCAGTCAT
TGAAAACTTAACGTTGGGTAGCCGTTCGAATATCACTGAAGCCGATATTGAAGCTGCCTGTTCAGTGGCGGAAATTGCCG
GAGATATTTCGAATTTGCCGCAGATATGGCAGACCAAACTTTCTGAAAGCGGCAGTATTTTATCGGGTGGACAAAAGCAG
CGCCTAGCAATTGCCCGCGCGTTATTATCACCGGCAAAAGTGTTGATTTTTGATGAATCGACCAGCAGTTTAGATACGAT
CACCGAGCGAAAAATTGTTGATCGGTTGTTAGCGATGACTGATCGAACCATTATTTTTGTGGCTCATCGGCTCACTATTG
CTGCTAAAACGGAACAGATTGTGGTCATGGATCATGGTGCGATTGTTGAACAAGGAAATCATGCTGAGTTATTGGCCAAA
CAAGGCTATTATGCTCGGTTGGTAAGTGAGTGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (16-152)

• ABC transporter transmembrane region (ABC_membrane) (180-448)

• ABC transporter (ABC_tran) (510-662)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	58.914	98.356	0.579
comA	Streptococcus pneumoniae Rx1	58.357	98.356	0.574
comA	Streptococcus pneumoniae D39	58.357	98.356	0.574
comA	Streptococcus pneumoniae R6	58.357	98.356	0.574
comA	Streptococcus mitis SK321	58.217	98.356	0.573
comA	Streptococcus pneumoniae TIGR4	57.939	98.356	0.57
comA	Streptococcus gordonii str. Challis substr. CH1	56.964	98.356	0.56
comA/nlmT	Streptococcus mutans UA159	54.986	98.904	0.544