Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   IPZ63_RS01315 Genome accession   NZ_CP063766
Coordinates   266909..268198 (-) Length   429 a.a.
NCBI ID   WP_002374326.1    Uniprot ID   A0A4Y3JMI1
Organism   Enterococcus lactis strain IDCC 2105     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 261909..273198
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IPZ63_RS01285 (IPZ63_01280) - 262111..263064 (-) 954 WP_002374319.1 glycosyltransferase family 2 protein -
  IPZ63_RS01290 (IPZ63_01285) - 263247..263597 (-) 351 WP_002292629.1 PepSY domain-containing protein -
  IPZ63_RS01295 (IPZ63_01290) pepA 263797..264876 (+) 1080 WP_002374321.1 glutamyl aminopeptidase -
  IPZ63_RS01300 (IPZ63_01295) - 265019..265339 (+) 321 WP_002374322.1 thioredoxin family protein -
  IPZ63_RS01305 (IPZ63_01300) - 265361..265825 (+) 465 WP_002292633.1 universal stress protein -
  IPZ63_RS01310 (IPZ63_01305) ytpR 266142..266747 (+) 606 WP_002374324.1 YtpR family tRNA-binding protein -
  IPZ63_RS01315 (IPZ63_01310) htrA 266909..268198 (-) 1290 WP_002374326.1 S1C family serine protease Regulator
  IPZ63_RS01320 (IPZ63_01315) rlmH 268626..269105 (+) 480 WP_025478483.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  IPZ63_RS01325 (IPZ63_01320) - 269155..270003 (+) 849 WP_002375160.1 LEM-3-like GIY-YIG domain-containing protein -
  IPZ63_RS01330 (IPZ63_01325) - 270341..271561 (+) 1221 Protein_266 alpha-L-rhamnosidase -
  IPZ63_RS01335 (IPZ63_01330) - 271739..272299 (-) 561 WP_002326412.1 TetR/AcrR family transcriptional regulator -
  IPZ63_RS01340 (IPZ63_01335) - 272441..273055 (+) 615 WP_025478569.1 GNAT family N-acetyltransferase -

Sequence

Protein


Download         Length: 429 a.a.        Molecular weight: 44939.95 Da        Isoelectric Point: 4.5419

>NTDB_id=496529 IPZ63_RS01315 WP_002374326.1 266909..268198(-) (htrA) [Enterococcus lactis strain IDCC 2105]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYIVTNNHVVDGQQGLEVLMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVNVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1290 bp        

>NTDB_id=496529 IPZ63_RS01315 WP_002374326.1 266909..268198(-) (htrA) [Enterococcus lactis strain IDCC 2105]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTAGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAGAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGGACTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAA
AAGACGGAAATACTGCTTATATAGTCACAAACAACCACGTAGTAGATGGACAGCAAGGTCTTGAAGTCTTGATGAAAGAC
GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGATAAAGT
CGAAACAGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAACCTGCGATTGCGATTGGTTCCCCATTAGGAT
CTGAATATGCGAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTAACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCGATCAACCCGGGAAATTCTGGTGGTCCTTTAGTGAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAACGTAAATGTAGAAGGAATGGGAT
TTGCCATCCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATATGATGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGCGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(127-272)

Peptidase family M50 (Peptidase_M50)

(10-417)

PDZ domain (PDZ_2)

(317-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4Y3JMI1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

54.315

91.841

0.499
  htrA Streptococcus mutans UA159

59.887

82.517

0.494
  htrA Streptococcus mitis NCTC 12261

52.778

92.308

0.487
  htrA Streptococcus pneumoniae TIGR4

59.05

78.555

0.464
  htrA Streptococcus pneumoniae D39

59.05

78.555

0.464
  htrA Streptococcus pneumoniae Rx1

59.05

78.555

0.464
  htrA Streptococcus pneumoniae R6

59.05

78.555

0.464