Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   SPYALAB49_RS02335 Genome accession   NC_017596
Coordinates   440693..441403 (+) Length   236 a.a.
NCBI ID   WP_002985645.1    Uniprot ID   -
Organism   Streptococcus pyogenes Alab49     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 435693..446403
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPYALAB49_RS02315 (SPYALAB49_000472) - 436545..436694 (+) 150 WP_002994198.1 hypothetical protein -
  SPYALAB49_RS02320 (SPYALAB49_000473) - 437089..438237 (+) 1149 WP_014635346.1 acetyl-CoA C-acyltransferase -
  SPYALAB49_RS02325 (SPYALAB49_000474) - 438194..439441 (+) 1248 WP_002995606.1 AMP-binding protein -
  SPYALAB49_RS02330 (SPYALAB49_000475) - 439497..440531 (+) 1035 WP_162467709.1 DUF3114 domain-containing protein -
  SPYALAB49_RS02335 (SPYALAB49_000476) vicR 440693..441403 (+) 711 WP_002985645.1 response regulator YycF Regulator
  SPYALAB49_RS02340 (SPYALAB49_000477) vicK 441396..442748 (+) 1353 WP_002985643.1 cell wall metabolism sensor histidine kinase VicK Regulator
  SPYALAB49_RS02345 (SPYALAB49_000478) vicX 442752..443561 (+) 810 WP_002985641.1 MBL fold metallo-hydrolase Regulator
  SPYALAB49_RS02350 (SPYALAB49_000479) rnc 443993..444685 (+) 693 WP_002985639.1 ribonuclease III -

Sequence

Protein


Download         Length: 236 a.a.        Molecular weight: 27083.99 Da        Isoelectric Point: 4.9038

>NTDB_id=49527 SPYALAB49_RS02335 WP_002985645.1 440693..441403(+) (vicR) [Streptococcus pyogenes Alab49]
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLIILDLMLPELDGLEVAKEIRKTSHVPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVE
LTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD

Nucleotide


Download         Length: 711 bp        

>NTDB_id=49527 SPYALAB49_RS02335 WP_002985645.1 440693..441403(+) (vicR) [Streptococcus pyogenes Alab49]
ATGAAAAAAATACTTATTGTGGATGATGAAAAACCGATTTCTGACATTATTAAGTTTAATTTGACAAAAGAAGGTTATGA
CATTGTTACAGCTTTTGATGGACGCGAAGCGGTAACAATTTTTGAAGAAGAAAAGCCAGATTTAATTATTCTTGATTTGA
TGCTCCCTGAGTTGGACGGTCTTGAAGTAGCCAAGGAAATTCGTAAAACCAGTCATGTCCCGATTATTATGTTGTCGGCT
AAAGATAGTGAGTTTGACAAGGTTATTGGACTTGAAATTGGGGCTGATGATTACGTGACCAAGCCTTTTTCTAATCGGGA
ATTGCTGGCGCGTGTCAAGGCTCATCTGCGTCGTACCGAAACTATTGAAACGGCTGTTGCAGAAGAAAATGCTTCTTCAG
GTACACAGGAACTAACCATTGGTAATTTACAGATTTTACCAGATGCGTTTGTTGCTAAAAAACATGGTCAAGAGGTAGAG
TTGACCCATCGTGAATTTGAACTATTGCATCATCTAGCTAACCATATGGGTCAGGTGATGACACGAGAACACTTATTGGA
AATTGTTTGGGGATATGATTATTTTGGCGATGTGCGCACGGTTGATGTGACTGTTCGTCGTCTCCGTGAAAAAATTGAAG
ACACACCAAGTCGTCCTGAGTATATTTTAACAAGACGTGGTGTTGGGTACTACATGAAATCTTATGACTAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

90.254

100

0.903
  micA Streptococcus pneumoniae Cp1015

79.06

99.153

0.784
  covR Streptococcus salivarius strain HSISS4

44.828

98.305

0.441
  covR Lactococcus lactis subsp. lactis strain DGCC12653

44.397

98.305

0.436
  scnR Streptococcus mutans UA159

36.91

98.729

0.364

Multiple sequence alignment