Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   SPYALAB49_RS01325 Genome accession   NC_017596
Coordinates   245441..246202 (+) Length   253 a.a.
NCBI ID   WP_002986029.1    Uniprot ID   -
Organism   Streptococcus pyogenes Alab49     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 240441..251202
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPYALAB49_RS01310 (SPYALAB49_000269) - 240699..242267 (-) 1569 WP_023080089.1 ABC transporter substrate-binding protein/permease -
  SPYALAB49_RS01315 (SPYALAB49_000270) - 242465..244390 (+) 1926 WP_014635279.1 DUF2207 domain-containing protein -
  SPYALAB49_RS01320 (SPYALAB49_000271) - 244456..245295 (+) 840 WP_002991126.1 undecaprenyl-diphosphate phosphatase -
  SPYALAB49_RS01325 (SPYALAB49_000272) mecA 245441..246202 (+) 762 WP_002986029.1 adaptor protein MecA Regulator
  SPYALAB49_RS01330 (SPYALAB49_000273) - 246209..247378 (+) 1170 WP_002991122.1 glycosyltransferase family 4 protein -
  SPYALAB49_RS01335 (SPYALAB49_000275) sufC 247500..248270 (+) 771 WP_002986023.1 Fe-S cluster assembly ATPase SufC -
  SPYALAB49_RS01340 (SPYALAB49_000276) sufD 248365..249627 (+) 1263 WP_014635280.1 Fe-S cluster assembly protein SufD -
  SPYALAB49_RS01345 (SPYALAB49_000277) - 249658..250884 (+) 1227 WP_002991117.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 253 a.a.        Molecular weight: 29051.72 Da        Isoelectric Point: 4.1622

>NTDB_id=49516 SPYALAB49_RS01325 WP_002986029.1 245441..246202(+) (mecA) [Streptococcus pyogenes Alab49]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEI
NKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPSTNHESEPLDYVH
YVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
DGAVEQLQKIELG

Nucleotide


Download         Length: 762 bp        

>NTDB_id=49516 SPYALAB49_RS01325 WP_002986029.1 245441..246202(+) (mecA) [Streptococcus pyogenes Alab49]
ATGGAAATGAAACAAATTAGCGAGACAACGCTAAAAATAACAATTAGTATGGACGATTTAGAAGAAAGAGGAATGGAGTT
GAAAGATTTCTTGATTCCTCAAGAAAAAACAGAAGAGTTTTTCTATTCTGTGATGGACGAACTCGATCTTCCAGATAATT
TTAAAGATAGTGGTATGCTTAGTTTTCGAGTGACTCCACGCAAGGACCGTCTAGATGTTTTTGTTACCAAATCTGAGATA
AATAAAGATATTAATCTTGAAGATTTAGCAGAGTTTGGTGATATGTCCCAAATGACTCCGGAAGATTTTTTCAAGAGCTT
GGAGCAATCCATGCGTGAAAAGGGAGATGTCAAAGCTCATGAAAAATTGGAAAAAATTGAAGAGATAATGGAAGATGTTG
TTGAAGCCACTCTAGCTAATCAGTCTGAGGCGGCTGATCCATCAACTAATCATGAGTCAGAACCTTTAGACTATGTCCAT
TATGTATTGGATTTTTCAACGATTACAGAGGCAGTGGCTTTTGCTAAAACGATTGATTTTTCGATAGAAGCTTCAGAGTT
ATATAAGGGGAGCAACTGCTACCATATGACTATTTTATTAGATGTTCAGCAACAACCATCTTATTTTGCGAATGTCATGT
ATGCGAGATTGATTGAGCATGCAAACCCTGGATCAAAAACAAGAGCTTATTTACAAGAGCATGGCTTACAATTGATGCTT
GATGGTGCTGTTGAGCAATTACAAAAGATTGAGTTGGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

63.2

98.814

0.625
  mecA Streptococcus thermophilus LMD-9

56.225

98.419

0.553
  mecA Streptococcus thermophilus LMG 18311

55.422

98.419

0.545
  mecA Streptococcus pneumoniae Rx1

48.235

100

0.486
  mecA Streptococcus pneumoniae D39

48.235

100

0.486
  mecA Streptococcus pneumoniae R6

48.235

100

0.486
  mecA Streptococcus pneumoniae TIGR4

48.235

100

0.486

Multiple sequence alignment