Detailed information NTG0049505

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: SPYALAB49_RS00330
• Genome accession: NC_017596
• Coordinates: 53398..54309 (+)
• Length: 303 a.a.
• NCBI ID: WP_014635220.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes Alab49
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48398..59309

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPYALAB49_RS00310 (SPYALAB49_000059)	purE	48693..49184 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
SPYALAB49_RS00315 (SPYALAB49_000060)	purK	49171..50244 (+)	1074	WP_002987718.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
SPYALAB49_RS00320 (SPYALAB49_000061)	-	50265..51605 (+)	1341	WP_014635219.1	hypothetical protein	-
SPYALAB49_RS00325 (SPYALAB49_000063)	purB	51975..53267 (+)	1293	WP_002986683.1	adenylosuccinate lyase	-
SPYALAB49_RS00330 (SPYALAB49_000064)	comR	53398..54309 (+)	912	WP_014635220.1	XRE family transcriptional regulator	Regulator
SPYALAB49_RS09870	comS	54400..54498 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
SPYALAB49_RS00335 (SPYALAB49_000065)	ruvB	54529..55527 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
SPYALAB49_RS00340 (SPYALAB49_000066)	-	55665..56102 (+)	438	WP_014635221.1	low molecular weight protein-tyrosine-phosphatase	-
SPYALAB49_RS00345 (SPYALAB49_000067)	-	56125..56526 (+)	402	WP_012560369.1	MORN repeat-containing protein	-
SPYALAB49_RS00350 (SPYALAB49_000068)	-	56523..58298 (+)	1776	WP_014635222.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35925.63 Da
• Isoelectric Point: 4.9349

>NTDB_id=49505 SPYALAB49_RS00330 WP_014635220.1 53398..54309(+) (comR) [Streptococcus pyogenes Alab49]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLPLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=49505 SPYALAB49_RS00330 WP_014635220.1 53398..54309(+) (comR) [Streptococcus pyogenes Alab49]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTACCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.34	100	0.993
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.492	98.68	0.469
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366