Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   SALIVA_RS02590 Genome accession   NC_017595
Coordinates   525144..525887 (-) Length   247 a.a.
NCBI ID   WP_014634051.1    Uniprot ID   -
Organism   Streptococcus salivarius JIM8777     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 511959..560513 525144..525887 within 0
IScluster/Tn 522218..527328 525144..525887 within 0


Gene organization within MGE regions


Location: 511959..560513
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SALIVA_RS02555 (SALIVA_0515) - 511959..513212 (-) 1254 WP_014634044.1 plasmid recombination protein -
  SALIVA_RS02560 (SALIVA_0516) - 513993..515837 (+) 1845 WP_014634045.1 SH3 domain-containing protein -
  SALIVA_RS02565 (SALIVA_0517) - 515968..516528 (+) 561 WP_014634046.1 hypothetical protein -
  SALIVA_RS02570 (SALIVA_0518) ldcB 516816..521339 (+) 4524 WP_014634047.1 LD-carboxypeptidase LdcB/DacB -
  SALIVA_RS10700 - 521392..522066 (+) 675 Protein_452 transposase -
  SALIVA_RS02580 (SALIVA_0521) - 522338..522655 (+) 318 Protein_453 transposase -
  SALIVA_RS02585 (SALIVA_0523) - 523818..525134 (-) 1317 WP_014634050.1 sensor histidine kinase -
  SALIVA_RS02590 (SALIVA_0524) comE/blpR 525144..525887 (-) 744 WP_014634051.1 response regulator transcription factor Regulator
  SALIVA_RS02600 (SALIVA_0527) tnpA 526912..527328 (+) 417 WP_014634053.1 IS200/IS605 family transposase -
  SALIVA_RS02605 (SALIVA_2088) - 527464..528441 (-) 978 WP_227070933.1 sensor histidine kinase KdpD -
  SALIVA_RS02610 (SALIVA_0528) - 528525..529196 (-) 672 WP_014634055.1 response regulator transcription factor -
  SALIVA_RS10500 (SALIVA_0529) - 529675..529803 (+) 129 WP_014634056.1 lasso RiPP family leader peptide-containing protein -
  SALIVA_RS02615 (SALIVA_0530) - 529883..531646 (+) 1764 WP_014634057.1 asparagine synthase-related protein -
  SALIVA_RS02620 (SALIVA_0531) - 531636..531902 (+) 267 WP_014634058.1 hypothetical protein -
  SALIVA_RS02625 - 531899..532318 (+) 420 WP_041826654.1 lasso peptide biosynthesis B2 protein -
  SALIVA_RS02630 (SALIVA_0532) - 532319..533026 (+) 708 WP_014634059.1 ABC transporter ATP-binding protein -
  SALIVA_RS02635 (SALIVA_0533) - 533032..533832 (+) 801 WP_014634060.1 ABC transporter permease -
  SALIVA_RS02640 (SALIVA_2089) - 533825..534514 (+) 690 WP_014634061.1 hypothetical protein -
  SALIVA_RS02645 (SALIVA_0534) - 534507..536249 (+) 1743 WP_014634062.1 ABC transporter ATP-binding protein -
  SALIVA_RS10300 - 536385..536572 (+) 188 Protein_467 transposase -
  SALIVA_RS02650 (SALIVA_0535) - 536833..537159 (-) 327 WP_014634063.1 helix-turn-helix domain-containing protein -
  SALIVA_RS02655 (SALIVA_0536) - 537320..540364 (+) 3045 WP_014634064.1 SEC10/PgrA surface exclusion domain-containing protein -
  SALIVA_RS02660 (SALIVA_0537) - 540512..540874 (+) 363 WP_003097334.1 hypothetical protein -
  SALIVA_RS02665 (SALIVA_0538) - 541058..542389 (+) 1332 WP_194184045.1 DUF6287 domain-containing protein -
  SALIVA_RS02670 (SALIVA_0539) - 542889..543272 (+) 384 WP_014634066.1 hypothetical protein -
  SALIVA_RS02675 (SALIVA_0540) - 543384..544022 (+) 639 WP_014634067.1 hypothetical protein -
  SALIVA_RS02680 (SALIVA_0541) - 544276..544683 (+) 408 WP_014634068.1 hypothetical protein -
  SALIVA_RS02685 (SALIVA_2090) - 544860..546221 (-) 1362 WP_014634069.1 hypothetical protein -
  SALIVA_RS02690 (SALIVA_0542) - 547045..547311 (+) 267 WP_014634070.1 DUF3173 family protein -
  SALIVA_RS02695 (SALIVA_0543) - 547301..548526 (+) 1226 Protein_477 tyrosine-type recombinase/integrase -
  SALIVA_RS02700 (SALIVA_0544) - 548983..550719 (+) 1737 WP_014634072.1 ABC transporter ATP-binding protein -
  SALIVA_RS02705 (SALIVA_0545) - 550732..552519 (+) 1788 WP_014634073.1 ABC transporter ATP-binding protein -
  SALIVA_RS02710 (SALIVA_0546) queA 552616..553659 (-) 1044 WP_014634074.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
  SALIVA_RS02715 (SALIVA_0547) - 553811..554512 (+) 702 WP_014634075.1 glucosamine-6-phosphate deaminase -
  SALIVA_RS02720 (SALIVA_0548) - 554661..555956 (-) 1296 WP_014634076.1 GHKL domain-containing protein -
  SALIVA_RS02725 (SALIVA_0549) - 555956..556666 (-) 711 WP_014634077.1 LytTR family DNA-binding domain-containing protein -
  SALIVA_RS02730 (SALIVA_0550) - 556821..557732 (+) 912 WP_014634078.1 ABC transporter ATP-binding protein -
  SALIVA_RS02735 (SALIVA_0551) - 557734..558456 (+) 723 WP_014634079.1 ABC transporter permease -
  SALIVA_RS02740 (SALIVA_0552) - 558646..559629 (+) 984 WP_014634080.1 rhodanese-related sulfurtransferase -
  SALIVA_RS02745 (SALIVA_0553) - 559808..560005 (+) 198 WP_014621323.1 helix-turn-helix transcriptional regulator -
  SALIVA_RS02750 (SALIVA_0554) - 560019..560513 (+) 495 WP_014634081.1 DUF6773 family protein -

Sequence

Protein


Download         Length: 247 a.a.        Molecular weight: 28712.13 Da        Isoelectric Point: 6.2535

>NTDB_id=49458 SALIVA_RS02590 WP_014634051.1 525144..525887(-) (comE/blpR) [Streptococcus salivarius JIM8777]
MLNIFILEDEFLQQTRIETVIKDVIAKKSLKCKGPEIFGKPSQLLDAITERGSHQLFFLDIEIKGEEKKGLDIAKEIRKK
DPNATIVFVTTHSEFMPVTFKYRVAALDFIDKALDDEDFYERVHLAIEYTMNKMGATIAQDSFTFETATAQVQVPFNNIL
FFETSPTIHKVILHTKEERMEFYASISEVERADDRLFRCHRSFIVNPENIVRINKEDKMVMFENNNECPISRTKYKALLE
KVKSLKS

Nucleotide


Download         Length: 744 bp        

>NTDB_id=49458 SALIVA_RS02590 WP_014634051.1 525144..525887(-) (comE/blpR) [Streptococcus salivarius JIM8777]
TTGTTAAATATTTTTATTTTAGAAGACGAATTTTTACAACAAACACGAATAGAGACCGTTATTAAGGATGTTATTGCAAA
AAAATCTCTAAAATGTAAAGGACCTGAGATTTTTGGAAAACCTAGCCAGCTACTTGATGCGATTACCGAAAGAGGTTCTC
ATCAACTTTTCTTTTTAGATATTGAAATTAAAGGAGAAGAAAAAAAGGGGCTAGACATTGCGAAAGAAATCCGAAAAAAA
GACCCTAATGCAACAATTGTTTTTGTAACAACACATTCAGAATTTATGCCAGTCACTTTTAAATATAGAGTTGCTGCACT
AGATTTTATTGATAAAGCTTTGGATGATGAAGATTTTTATGAACGTGTTCATTTAGCAATTGAATATACCATGAATAAAA
TGGGTGCTACTATCGCTCAAGATTCATTTACTTTTGAAACAGCTACGGCTCAAGTTCAAGTTCCTTTTAACAATATCTTA
TTTTTTGAAACGTCTCCAACAATACATAAAGTTATTTTGCATACTAAAGAAGAACGCATGGAGTTCTACGCCAGTATTTC
AGAAGTTGAACGAGCTGATGACCGCCTATTTCGATGCCATCGTTCATTTATCGTTAATCCTGAAAATATCGTTAGGATCA
ATAAAGAAGATAAAATGGTCATGTTTGAAAATAATAATGAATGTCCCATTTCGCGTACGAAATATAAGGCCCTCCTAGAA
AAAGTTAAATCTTTGAAAAGCTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-123)

LytTr DNA-binding domain (LytTR)

(152-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.812

96.761

0.53
  comE/comE1 Streptococcus equinus JB1

45.679

98.381

0.449
  comE/comE2 Streptococcus equinus JB1

39.837

99.595

0.397
  comE/comE2 Streptococcus gordonii strain NCTC7865

38.057

100

0.381
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

38.057

100

0.381

Multiple sequence alignment