Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   IM723_RS08160 Genome accession   NZ_CP063275
Coordinates   1579533..1581623 (-) Length   696 a.a.
NCBI ID   WP_232974663.1    Uniprot ID   -
Organism   Streptococcus thermophilus strain DMST-H2     
Function   transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1540671..1610911 1579533..1581623 within 0


Gene organization within MGE regions


Location: 1540671..1610911
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IM723_RS07960 - 1540695..1541477 (+) 783 WP_065972538.1 ABC transporter ATP-binding protein -
  IM723_RS07965 - 1542096..1544162 (-) 2067 WP_022096502.1 sodium:proton antiporter -
  IM723_RS07970 - 1544171..1544413 (-) 243 WP_011226461.1 hypothetical protein -
  IM723_RS07975 - 1544410..1544958 (-) 549 WP_011226462.1 class I SAM-dependent methyltransferase -
  IM723_RS07980 - 1544955..1545899 (-) 945 WP_022096500.1 TIGR01212 family radical SAM protein -
  IM723_RS07985 sepM 1545984..1547060 (-) 1077 WP_022096499.1 SepM family pheromone-processing serine protease Regulator
  IM723_RS07990 coaD 1547038..1547535 (-) 498 WP_022096498.1 pantetheine-phosphate adenylyltransferase -
  IM723_RS07995 rsmD 1547569..1548168 (-) 600 Protein_1531 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  IM723_RS08000 trxB 1548259..1549212 (-) 954 WP_255136104.1 thioredoxin-disulfide reductase -
  IM723_RS08005 - 1549245..1549469 (-) 225 WP_087010135.1 DUF4059 family protein -
  IM723_RS08010 - 1549684..1550427 (-) 744 WP_087010136.1 amino acid ABC transporter ATP-binding protein -
  IM723_RS08015 - 1550427..1551173 (-) 747 WP_095559509.1 amino acid ABC transporter permease -
  IM723_RS08020 - 1551561..1552391 (-) 831 WP_014608653.1 transporter substrate-binding domain-containing protein -
  IM723_RS08025 - 1552852..1553085 (-) 234 WP_002947030.1 hypothetical protein -
  IM723_RS08030 dinB 1553383..1554486 (-) 1104 WP_141326697.1 DNA polymerase IV -
  IM723_RS08035 pflB 1554765..1557074 (+) 2310 WP_002947035.1 formate C-acetyltransferase -
  IM723_RS08040 - 1557341..1558123 (+) 783 Protein_1540 carbonic anhydrase family protein -
  IM723_RS08045 - 1558174..1558626 (+) 453 WP_176243562.1 GNAT family N-acetyltransferase -
  IM723_RS08050 - 1558978..1559283 (-) 306 WP_164178283.1 restriction endonuclease subunit S -
  IM723_RS10335 mobV 1559308..1559816 (-) 509 Protein_1543 MobV family relaxase -
  IM723_RS08060 - 1560297..1560885 (-) 589 Protein_1544 site-specific integrase -
  IM723_RS08065 - 1560973..1561659 (-) 687 WP_084829831.1 hypothetical protein -
  IM723_RS08070 fetB 1561735..1562490 (-) 756 WP_002951770.1 iron export ABC transporter permease subunit FetB -
  IM723_RS08075 - 1562487..1563137 (-) 651 WP_141326707.1 ATP-binding cassette domain-containing protein -
  IM723_RS08080 - 1563339..1564295 (-) 957 WP_002951776.1 serine hydrolase domain-containing protein -
  IM723_RS08085 - 1564295..1565050 (-) 756 WP_179971651.1 CppA family protein -
  IM723_RS08090 - 1565332..1565607 (+) 276 WP_224103608.1 CPBP family intramembrane glutamic endopeptidase -
  IM723_RS08095 gla 1565781..1566644 (-) 864 WP_002951781.1 aquaglyceroporin Gla -
  IM723_RS08100 - 1566765..1569032 (+) 2268 WP_211836859.1 Xaa-Pro dipeptidyl-peptidase -
  IM723_RS08105 - 1569112..1569492 (-) 381 WP_002951783.1 hypothetical protein -
  IM723_RS08110 - 1569617..1569880 (-) 264 WP_002945924.1 hypothetical protein -
  IM723_RS08115 - 1570202..1570498 (-) 297 WP_004197070.1 bacteriocin immunity protein -
  IM723_RS08120 - 1570663..1571505 (-) 843 WP_232973669.1 thioredoxin family protein -
  IM723_RS08125 - 1571784..1573354 (+) 1571 WP_180481099.1 IS3-like element ISSth1b family transposase -
  IM723_RS08130 - 1573500..1573766 (-) 267 WP_211836860.1 Blp family class II bacteriocin -
  IM723_RS10340 - 1574017..1574418 (-) 402 WP_011226490.1 hypothetical protein -
  IM723_RS08135 - 1575405..1575635 (-) 231 WP_011226494.1 bacteriocin class II family protein -
  IM723_RS08140 - 1575885..1576616 (+) 732 WP_002948869.1 LytTR family DNA-binding domain-containing protein -
  IM723_RS10100 - 1577153..1577956 (+) 804 WP_224103634.1 ATP-binding protein -
  IM723_RS08150 - 1577974..1578135 (-) 162 WP_011226496.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  IM723_RS08155 - 1578150..1579517 (-) 1368 WP_084829837.1 bacteriocin secretion accessory protein -
  IM723_RS08160 comA/nlmT 1579533..1581623 (-) 2091 WP_232974663.1 peptide cleavage/export ABC transporter Regulator
  IM723_RS08165 - 1582700..1584445 (-) 1746 WP_024703994.1 ABC transporter ATP-binding protein -
  IM723_RS08170 - 1584438..1586195 (-) 1758 WP_211836861.1 ABC transporter transmembrane domain-containing protein -
  IM723_RS10105 - 1586382..1586588 (-) 207 WP_002948879.1 hypothetical protein -
  IM723_RS08180 - 1586793..1587320 (-) 528 WP_011227521.1 VanZ family protein -
  IM723_RS08185 rlmN 1587322..1588431 (-) 1110 WP_211837052.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  IM723_RS08190 - 1588495..1589217 (-) 723 WP_211836862.1 YutD family protein -
  IM723_RS08195 - 1589272..1590627 (-) 1356 WP_206285289.1 metallophosphatase -
  IM723_RS08200 - 1590906..1591145 (-) 240 WP_211836863.1 transcriptional regulator -
  IM723_RS08205 - 1591475..1592818 (-) 1344 WP_211836864.1 DEAD/DEAH box helicase -
  IM723_RS08210 mraY 1592893..1593915 (-) 1023 WP_211836865.1 phospho-N-acetylmuramoyl-pentapeptide- transferase -
  IM723_RS08215 pbp2X 1593917..1596184 (-) 2268 WP_211836866.1 penicillin-binding protein PBP2X -
  IM723_RS08220 ftsL 1596188..1596508 (-) 321 WP_014727681.1 cell division protein FtsL -
  IM723_RS08225 rsmH 1596511..1597461 (-) 951 WP_002888254.1 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH -
  IM723_RS10110 - 1597619..1598233 (-) 615 WP_244810378.1 hypothetical protein -
  IM723_RS10115 - 1598230..1598616 (-) 387 WP_244810380.1 hypothetical protein -
  IM723_RS08235 - 1598720..1598947 (+) 228 WP_211836867.1 hypothetical protein -
  IM723_RS08240 - 1599253..1599609 (-) 357 WP_211836868.1 DUF805 domain-containing protein -
  IM723_RS08245 - 1599829..1600122 (-) 294 WP_232979664.1 hypothetical protein -
  IM723_RS08250 - 1600457..1601707 (-) 1251 WP_211836869.1 glutamate-5-semialdehyde dehydrogenase -
  IM723_RS08255 proB 1601709..1602512 (-) 804 WP_002948808.1 glutamate 5-kinase -
  IM723_RS08260 - 1602633..1604189 (-) 1557 WP_244810421.1 ABC transporter permease -
  IM723_RS08265 - 1604222..1604953 (-) 732 Protein_1587 ABC transporter ATP-binding protein -
  IM723_RS08270 - 1605226..1605959 (+) 734 Protein_1588 DUF554 domain-containing protein -
  IM723_RS08275 addA 1606353..1610006 (-) 3654 WP_211836870.1 helicase-exonuclease AddAB subunit AddA -

Sequence

Protein


Download         Length: 696 a.a.        Molecular weight: 78150.55 Da        Isoelectric Point: 6.5161

>NTDB_id=494182 IM723_RS08160 WP_232974663.1 1579533..1581623(-) (comA/nlmT) [Streptococcus thermophilus strain DMST-H2]
MASVAKYYGSDYSLAHLRELAKTNKEGTTALGLVEAAKKIGFETRAIKAEMSLFEMEDVPYPFIAHVNKDGKLQHYYVIY
KSTKDYLIIGDPDPSVKVTKMTKERFEKEWTGVTLFMGPEPSYKPHKDKKNGLWDFLTLIFKQRSLIANIVFASLLVTLI
NILGSYYLQGILDEYVPNQMKSTLGIISIGLVVTYVLQQMMTFARDYLLTILSQRLTIDVILSYIRHIFELPMSFFATRR
TGEVISRFSDANSIIDALASTILSLFLDFSIVIIVGGVLLIQNSNLFKLVLCSVPIYTLIVFAFMKPFERMNHDVMQSNA
MVNSAIIEDINGIETIKLLTSEEVCYQKIDGEFVDYLDNSFRLSKLSILQTSLKQGAQLILNVLILWTGAQLVMGNTISI
GQLITFNMLLSYFTNPLENIINLQTKLQSAKVANTRLNEVYLIESEFGQSDDTYQEGIADGDITVTDLSYKYGFGRDTLT
DVSLTIRQGEKISFVGVSGSGKTTLAKMLVNFYQPYKGHIDFNGQNISRIEKKTLRQHINYLPQQSYIFSGSVLENLTLG
AARGITQADILKACEIAEIRQDIENMPMGFQTELSDGAGLSGGQKQRIALARALLTKSPVLILDEATSGLDVLTEKQVID
NLLALKDKTIIFVAHRLSIAERTDRIVVIDQGRVVETGSHQDLMSYPGFYYQLFRK

Nucleotide


Download         Length: 2091 bp        

>NTDB_id=494182 IM723_RS08160 WP_232974663.1 1579533..1581623(-) (comA/nlmT) [Streptococcus thermophilus strain DMST-H2]
TTGGCATCAGTGGCCAAGTACTATGGTTCAGATTATTCATTAGCACATCTGCGTGAGTTGGCGAAGACCAATAAAGAAGG
GACAACTGCCTTAGGTCTTGTAGAGGCTGCTAAAAAAATTGGCTTTGAAACGAGAGCTATAAAGGCTGAAATGTCGCTCT
TTGAGATGGAAGATGTTCCTTATCCTTTTATTGCTCATGTTAATAAAGATGGGAAGCTTCAACATTATTATGTTATTTAT
AAAAGCACCAAGGATTATCTGATAATTGGAGACCCTGATCCAAGTGTAAAAGTAACTAAAATGACTAAAGAGCGTTTTGA
GAAAGAGTGGACAGGTGTTACTCTTTTTATGGGACCGGAACCCAGTTATAAACCACATAAGGATAAGAAAAATGGACTCT
GGGACTTTCTCACTTTGATCTTTAAACAAAGGTCCTTGATAGCTAATATTGTCTTTGCCAGTCTCTTGGTTACTTTAATA
AATATTTTAGGTTCCTATTATTTACAAGGTATTCTAGACGAATATGTCCCTAATCAAATGAAGTCTACCTTAGGAATTAT
CTCAATTGGATTAGTTGTGACCTATGTTTTACAACAAATGATGACTTTTGCAAGAGATTATCTCTTAACCATACTGAGTC
AGCGATTGACCATTGACGTTATCTTGTCCTACATACGACATATCTTTGAACTCCCAATGTCTTTTTTTGCCACAAGACGT
ACAGGGGAGGTTATCTCACGTTTTAGTGATGCTAACTCTATTATCGATGCTCTGGCTTCGACGATATTATCACTTTTCCT
TGATTTCTCTATTGTGATTATCGTAGGAGGCGTGTTATTGATACAAAATAGCAATCTCTTCAAGCTAGTTCTTTGTTCGG
TTCCAATTTATACCCTTATCGTCTTTGCCTTTATGAAACCTTTTGAGCGAATGAATCATGACGTCATGCAGAGTAATGCT
ATGGTTAATTCAGCCATCATTGAGGACATTAATGGGATTGAAACCATAAAGTTACTAACCAGCGAAGAAGTATGCTATCA
AAAGATTGATGGTGAGTTTGTTGACTATCTAGACAATTCTTTTCGCCTTTCTAAGTTATCTATACTACAAACATCATTGA
AACAAGGTGCTCAACTTATTTTAAATGTACTTATCCTCTGGACAGGTGCTCAGTTGGTGATGGGAAATACCATTTCGATA
GGACAATTGATTACTTTTAATATGTTGCTTTCCTACTTCACGAATCCTTTGGAAAATATCATTAACCTGCAAACCAAGTT
ACAGTCTGCTAAGGTAGCTAATACTAGGCTCAATGAGGTCTATCTGATTGAATCAGAGTTTGGACAAAGTGATGATACCT
ATCAAGAAGGCATTGCGGATGGAGATATCACTGTTACGGATTTATCTTATAAATATGGTTTTGGTCGTGATACTTTGACT
GATGTCAGTTTGACGATTAGACAAGGAGAAAAAATCAGTTTTGTTGGTGTCAGTGGATCTGGTAAGACTACTCTAGCTAA
AATGTTGGTCAATTTTTATCAACCATATAAGGGGCACATAGATTTTAATGGTCAAAATATTAGTCGCATAGAGAAGAAAA
CTCTTCGTCAACATATTAACTATCTCCCTCAGCAATCCTATATATTTAGTGGTAGTGTTTTAGAAAATCTTACTTTAGGT
GCAGCACGGGGTATTACACAAGCTGATATTTTGAAAGCTTGTGAAATAGCAGAAATTCGTCAAGATATTGAAAACATGCC
TATGGGGTTTCAGACAGAGCTGTCTGATGGAGCAGGTCTGTCTGGAGGGCAAAAGCAACGTATCGCTTTGGCGCGTGCAC
TACTAACGAAATCTCCTGTACTAATCTTAGATGAAGCAACTAGCGGATTGGATGTTTTGACAGAAAAGCAGGTTATTGAT
AACCTCCTAGCACTAAAAGATAAAACGATCATCTTTGTAGCACACAGGCTTAGTATCGCTGAGCGGACCGACCGTATCGT
AGTCATTGATCAGGGACGCGTAGTGGAGACAGGTTCTCATCAAGACCTGATGTCTTATCCAGGTTTCTATTATCAATTAT
TTAGAAAGTGA

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(2-121)

ABC transporter (ABC_tran)

(479-628)

ABC transporter transmembrane region (ABC_membrane)

(149-417)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

68.012

99.713

0.678
  comA Streptococcus mitis NCTC 12261

66.282

99.713

0.661
  comA Streptococcus pneumoniae Rx1

65.85

99.713

0.657
  comA Streptococcus pneumoniae D39

65.85

99.713

0.657
  comA Streptococcus pneumoniae R6

65.85

99.713

0.657
  comA Streptococcus mitis SK321

65.562

99.713

0.654
  comA Streptococcus pneumoniae TIGR4

65.418

99.713

0.652
  comA Streptococcus gordonii str. Challis substr. CH1

64.121

99.713

0.639