Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   IM723_RS01010 Genome accession   NZ_CP063275
Coordinates   171681..172430 (+) Length   249 a.a.
NCBI ID   WP_011225365.1    Uniprot ID   Q5M699
Organism   Streptococcus thermophilus strain DMST-H2     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 166681..177430
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IM723_RS00980 - 167255..167425 (+) 171 WP_172838670.1 hypothetical protein -
  IM723_RS00985 - 167512..167619 (+) 108 WP_084829946.1 LPXTG cell wall anchor domain-containing protein -
  IM723_RS00990 - 167707..168447 (-) 741 WP_002949253.1 amino acid ABC transporter ATP-binding protein -
  IM723_RS00995 - 168447..169997 (-) 1551 WP_011225362.1 ABC transporter substrate-binding protein/permease -
  IM723_RS01000 - 170200..171054 (+) 855 WP_041828107.1 undecaprenyl-diphosphate phosphatase -
  IM723_RS01005 - 171200..171415 (-) 216 WP_011226805.1 DUF3021 family protein -
  IM723_RS01010 mecA 171681..172430 (+) 750 WP_011225365.1 adaptor protein MecA Regulator
  IM723_RS01015 - 172434..173591 (+) 1158 WP_002947632.1 MraY family glycosyltransferase -
  IM723_RS01020 sufC 173752..174522 (+) 771 WP_002947634.1 Fe-S cluster assembly ATPase SufC -
  IM723_RS01025 sufD 174559..175821 (+) 1263 WP_002947640.1 Fe-S cluster assembly protein SufD -
  IM723_RS01030 - 175875..177107 (+) 1233 WP_211836933.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29157.70 Da        Isoelectric Point: 4.0659

>NTDB_id=494140 IM723_RS01010 WP_011225365.1 171681..172430(+) (mecA) [Streptococcus thermophilus strain DMST-H2]
MEMKQINETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEALDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAF
SDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL
PVLQATKWS

Nucleotide


Download         Length: 750 bp        

>NTDB_id=494140 IM723_RS01010 WP_011225365.1 171681..172430(+) (mecA) [Streptococcus thermophilus strain DMST-H2]
ATGGAAATGAAACAAATAAACGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT
GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT
TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT
AAGGAAGCCCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT
TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG
ATGAGACTATGACAGAGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC
TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAATTTTATAAACTTGG
TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q5M699

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus thermophilus LMG 18311

100

100

1
  mecA Streptococcus thermophilus LMD-9

99.197

100

0.992
  mecA Streptococcus mutans UA159

57.377

97.992

0.562
  mecA Streptococcus pneumoniae Rx1

46.185

100

0.462
  mecA Streptococcus pneumoniae D39

46.185

100

0.462
  mecA Streptococcus pneumoniae R6

46.185

100

0.462
  mecA Streptococcus pneumoniae TIGR4

46.185

100

0.462