Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   SPNOXC_RS06440 Genome accession   NC_017592
Coordinates   1216260..1216997 (-) Length   245 a.a.
NCBI ID   WP_000782676.1    Uniprot ID   A0A064C3U8
Organism   Streptococcus pneumoniae OXC141     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1211260..1221997
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPNOXC_RS06420 (SPNOXC11930) msrB 1212764..1213702 (-) 939 WP_000818203.1 peptide-methionine (R)-S-oxide reductase MsrB -
  SPNOXC_RS06430 (SPNOXC11940) thrB 1213952..1214821 (-) 870 WP_000692438.1 homoserine kinase -
  SPNOXC_RS06435 (SPNOXC11950) - 1214823..1216109 (-) 1287 WP_000216376.1 homoserine dehydrogenase -
  SPNOXC_RS06440 (SPNOXC11960) mecA 1216260..1216997 (-) 738 WP_000782676.1 adaptor protein MecA Regulator
  SPNOXC_RS06445 (SPNOXC11970) - 1217197..1218231 (-) 1035 WP_000461498.1 hypothetical protein -
  SPNOXC_RS06450 (SPNOXC11980) - 1218260..1219693 (-) 1434 WP_000565097.1 O-antigen polysaccharide polymerase Wzy family protein -
  SPNOXC_RS06455 (SPNOXC11990) - 1219709..1220695 (-) 987 WP_000446977.1 glycosyltransferase family 2 protein -
  SPNOXC_RS06460 (SPNOXC12000) - 1220697..1221800 (-) 1104 WP_000225903.1 glycosyltransferase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28381.18 Da        Isoelectric Point: 4.0199

>NTDB_id=49241 SPNOXC_RS06440 WP_000782676.1 1216260..1216997(-) (mecA) [Streptococcus pneumoniae OXC141]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=49241 SPNOXC_RS06440 WP_000782676.1 1216260..1216997(-) (mecA) [Streptococcus pneumoniae OXC141]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A064C3U8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.592

100

0.996
  mecA Streptococcus pneumoniae D39

99.592

100

0.996
  mecA Streptococcus pneumoniae R6

99.592

100

0.996
  mecA Streptococcus pneumoniae TIGR4

99.184

100

0.992
  mecA Streptococcus thermophilus LMD-9

47.791

100

0.486
  mecA Streptococcus thermophilus LMG 18311

47.39

100

0.482
  mecA Streptococcus mutans UA159

48.163

100

0.482

Multiple sequence alignment