NTDB

Overview

Name	dprA	Type	Machinery gene
Locus tag	KFU63_RS02325	Genome accession	NZ_CP074042
Coordinates	476677..477801 (+)	Length	374 a.a.
NCBI ID	WP_000228531.1	Uniprot ID	A7ZSH4
Organism	Escherichia coli strain PI6
Function	ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 471677..482801

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KFU63_RS02300 (KFU63_02265)	mscL	471803..472213 (-)	411	WP_000022439.1	large-conductance mechanosensitive channel protein MscL	-
KFU63_RS02305 (KFU63_02270)	trkA	472343..473719 (-)	1377	WP_000691382.1	Trk system potassium transporter TrkA	-
KFU63_RS02310 (KFU63_02275)	rsmB	473741..475030 (-)	1290	WP_000744779.1	16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB	-
KFU63_RS02315 (KFU63_02280)	fmt	475076..476023 (-)	948	WP_000004432.1	methionyl-tRNA formyltransferase	-
KFU63_RS02320 (KFU63_02285)	def	476038..476547 (-)	510	WP_000114984.1	peptide deformylase	-
KFU63_RS02325 (KFU63_02290)	dprA	476677..477801 (+)	1125	WP_000228531.1	DNA-protecting protein DprA	Machinery gene
KFU63_RS02330 (KFU63_02295)	smg	477773..478246 (+)	474	WP_000460672.1	DUF494 family protein Smg	-
KFU63_RS02335 (KFU63_02300)	yrdD	478275..478817 (+)	543	WP_096971029.1	type I DNA topoisomerase	-
KFU63_RS02340 (KFU63_02305)	tsaC	478822..479394 (+)	573	WP_001297709.1	L-threonylcarbamoyladenylate synthase type 1 TsaC	-
KFU63_RS02345 (KFU63_02310)	aroE	479399..480217 (+)	819	WP_000451211.1	shikimate dehydrogenase	-
KFU63_RS02350 (KFU63_02315)	yrdB	480214..480471 (+)	258	WP_001070563.1	DUF1488 domain-containing protein	-
KFU63_RS02355 (KFU63_02320)	yrdA	480447..481001 (-)	555	WP_001286216.1	gamma carbonic anhydrase family protein	-

Sequence

Protein

Download Length: 374 a.a. Molecular weight: 40986.98 Da Isoelectric Point: 6.3122

                                >NTDB_id=490343 KFU63_RS02325 WP_000228531.1 476677..477801(+) (dprA) [Escherichia coli strain PI6]

MVDTEIWLRLMSISSLYGDDMVRIAHWLAKQSQIDAVGLQQTGLTLRQAQRFLSFPRKSIESSLCWLEQPNHHLIPADSE

FYPPQLLMTTDYPGALFVEGELHALHSFQLAVVGSRAHSWYGERWGRLFCETLATRGVTITSGLARGIDGVAHKAALQVN

GVSIAVLGNGLNTIHPRRHARLAASLLEHGGALVSEFPLDVPPLAYNFPRRNRIISGLSKGVLVVEAALRSGSLVTARCA

LEQGREVFALPGPIGNPGSEGPHWLIKQGAILVTEPEEILENLQFGLHWLPDAPENSFYSPDQQDVALPFPELLANVGDE

VTPVDVVAERAGQPVPEVVTQLLELELAGWIAAVPGGYVRLRRACHVRRTNVFV

Nucleotide

Download Length: 1125 bp

                                >NTDB_id=490343 KFU63_RS02325 WP_000228531.1 476677..477801(+) (dprA) [Escherichia coli strain PI6]

ATGGTCGATACAGAAATTTGGCTGCGTTTAATGAGTATCAGCAGCTTGTACGGCGATGATATGGTCCGTATAGCTCACTG

GCTGGCAAAACAGTCGCAAATTGATGCGGTTGGATTGCAGCAAACAGGGCTTACATTGCGGCAGGCACAACGCTTTCTTT

CATTTCCGCGAAAGAGTATCGAAAGCTCACTTTGTTGGTTGGAGCAACCCAACCATCATTTAATCCCTGCGGACAGCGAA

TTTTATCCTCCTCAACTTCTGATGACGACAGATTACCCCGGTGCACTGTTTGTTGAAGGAGAACTGCACGCGCTGCATTC

ATTTCAGCTTGCCGTAGTGGGGAGTCGGGCGCATTCATGGTATGGCGAGCGATGGGGACGGTTATTTTGCGAAACTCTGG

CGACGCGTGGAGTGACAATTACGAGTGGACTGGCGCGTGGAATCGATGGTGTGGCGCATAAAGCTGCCTTACAGGTAAAT

GGCGTCAGCATTGCTGTATTGGGGAATGGACTTAATACCATTCATCCCCGCCGCCATGCCCGACTGGCTGCCAGTCTGCT

TGAACATGGCGGAGCTCTCGTCTCGGAATTTCCCCTCGATGTTCCACCCCTTGCTTACAATTTCCCACGAAGAAATCGCA

TTATCAGTGGTCTAAGTAAAGGTGTACTGGTGGTGGAAGCGGCTTTGCGCAGTGGTTCGCTGGTGACAGCACGTTGTGCG

CTTGAGCAGGGGCGTGAAGTTTTTGCCTTGCCAGGTCCAATAGGGAATCCGGGAAGCGAAGGGCCTCACTGGTTAATAAA

ACAAGGTGCGATTCTTGTGACGGAACCGGAAGAAATTCTGGAAAACTTGCAATTTGGATTGCACTGGTTGCCAGACGCCC

CTGAAAATTCATTTTATTCACCAGATCAGCAAGACGTGGCATTGCCATTTCCTGAGCTCCTGGCTAACGTAGGAGATGAG

GTAACACCTGTTGACGTCGTCGCTGAACGTGCCGGCCAACCTGTGCCAGAGGTAGTTACTCAACTACTCGAACTGGAGTT

AGCAGGATGGATCGCAGCTGTACCCGGCGGCTATGTCCGATTGAGGAGGGCATGCCATGTTCGACGTACTAATGTATTTG

TTTGA

Domains

Predicted by InterProScan.

DNA recombination-mediator protein A (DNA_processg_A)

(67-274)

DprA winged helix domain (WHD_DprA)

(312-357)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A7ZSH4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
dprA	Vibrio campbellii strain DS40M4	48.509	98.663	0.479
dprA	Vibrio cholerae O1 biovar El Tor strain E7946	44.865	98.93	0.444
dprA	Vibrio cholerae strain A1552	44.865	98.93	0.444
dprA	Haemophilus influenzae Rd KW20	45.401	90.107	0.409
dprA	Glaesserella parasuis strain SC1401	44.838	90.642	0.406
dprA	Legionella pneumophila strain ERS1305867	44.545	88.235	0.393

Detailed information NTG0490343