Detailed information NTG0483424

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: J7T61_RS07745
• Genome accession: NZ_CP072441
• Coordinates: 1473399..1474184 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain S24728
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1468399..1479184

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J7T61_RS07710 (J7T61_07665)	gatC	1468462..1468764 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
J7T61_RS07715 (J7T61_07670)	-	1468904..1469158 (-)	255	WP_024010053.1	glycosyl transferase	-
J7T61_RS07720 (J7T61_07675)	-	1469171..1469380 (-)	210	WP_080998437.1	glycosyltransferase	-
J7T61_RS07725 (J7T61_07680)	-	1469696..1471139 (-)	1444	Protein_1468	6-phospho-beta-glucosidase	-
J7T61_RS07730 (J7T61_07685)	msrA	1471292..1471801 (-)	510	WP_041827375.1	peptide-methionine (S)-S-oxide reductase MsrA	-
J7T61_RS07735 (J7T61_07690)	-	1471813..1472661 (-)	849	Protein_1470	MetQ/NlpA family ABC transporter substrate-binding protein	-
J7T61_RS07740 (J7T61_07695)	-	1472785..1473336 (-)	552	WP_084826114.1	cysteine hydrolase family protein	-
J7T61_RS07745 (J7T61_07700)	codY	1473399..1474184 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
J7T61_RS07750 (J7T61_07705)	-	1474444..1475658 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
J7T61_RS07755 (J7T61_07710)	-	1476013..1476465 (+)	453	WP_002946987.1	universal stress protein	-
J7T61_RS07760	-	1476645..1477216 (+)	572	Protein_1475	IS30 family transposase	-
J7T61_RS07765	-	1477288..1477884 (-)	597	WP_232086461.1	hypothetical protein	-
J7T61_RS07770 (J7T61_07720)	pflA	1478096..1478896 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=483424 J7T61_RS07745 WP_002951720.1 1473399..1474184(-) (codY) [Streptococcus thermophilus strain S24728]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=483424 J7T61_RS07745 WP_002951720.1 1473399..1474184(-) (codY) [Streptococcus thermophilus strain S24728]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502