Detailed information NTG0480998

Bioinformatically predicted

Overview

• Name: pknB
• Type: Regulator
• Locus tag: IB935_RS06925
• Genome accession: NZ_CP061134
• Coordinates: 1362900..1364798 (-)
• Length: 632 a.a.
• NCBI ID: WP_011018054.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain BSAC_bs192 isolate Invasive disease
• Function: modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology) Competence regulation

Genomic Context

Location: 1357900..1369798

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IB935_RS06900 (IB935_06900)	-	1358636..1359013 (-)	378	WP_002983674.1	S1 RNA-binding domain-containing protein	-
IB935_RS06905 (IB935_06905)	-	1359013..1360413 (-)	1401	WP_021299066.1	bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase	-
IB935_RS06910 (IB935_06910)	-	1360450..1361091 (-)	642	WP_002983671.1	response regulator transcription factor	-
IB935_RS06915 (IB935_06915)	-	1361084..1362088 (-)	1005	WP_011528855.1	sensor histidine kinase	-
IB935_RS06920 (IB935_06920)	liaF	1362085..1362777 (-)	693	WP_011054833.1	cell wall-active antibiotics response protein LiaF	-
IB935_RS06925 (IB935_06925)	pknB	1362900..1364798 (-)	1899	WP_011018054.1	Stk1 family PASTA domain-containing Ser/Thr kinase	Regulator
IB935_RS06930 (IB935_06930)	-	1364795..1365535 (-)	741	WP_002983660.1	Stp1/IreP family PP2C-type Ser/Thr phosphatase	-
IB935_RS06935 (IB935_06935)	rsmB	1365573..1366895 (-)	1323	WP_011528856.1	16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB	-
IB935_RS06940 (IB935_06940)	fmt	1366885..1367820 (-)	936	WP_011018056.1	methionyl-tRNA formyltransferase	-

Sequence

Protein

• Length: 632 a.a.
• Molecular weight: 68849.09 Da
• Isoelectric Point: 7.2899

>NTDB_id=480998 IB935_RS06925 WP_011018054.1 1362900..1364798(-) (pknB) [Streptococcus pyogenes strain BSAC_bs192 isolate Invasive disease]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGADLKRYIQNHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKEGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIEENHNVP
QALENVVIRATAKKLSDRYGSTFEMSRDLMTALSYNRSRERKIIFEDVESTKPLPKVASGPTASVKLSPPTPTVLTQESR
LDQTNQTDALQPPTKKKKSGRFLGTLFKILFSFFIVGVALFTYLILTKPTSVKVPNVAGTSLKVAKQELYDVGLKVGKIR
QIESDTVAEGNVVRTDPKAGTAKRQGSSITLYVSIGNKGFDMENYKGLDYQEAMNSLIETYGVPKSKIKIERIVTNEYPE
NTVISQSPSAGDKFNPNGKSKITLSVAVSDTITMPMVTEYSYADAVNTLTALGIDASRIKAYVPSSSSATGFVPIHSPSS
KAIVSGQSPYYGTSLSLSDKGEISLYLYPEETHSSSSSSSSTSSSNSSSTNDSTAPGSNTELSPSETTSQTP

Nucleotide

• Length: 1899 bp

>NTDB_id=480998 IB935_RS06925 WP_011018054.1 1362900..1364798(-) (pknB) [Streptococcus pyogenes strain BSAC_bs192 isolate Invasive disease]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGCATTCTGAAATCTATTGGCCGCGGTGGTATGGCGGATGTTTA
TTTAGCAAATGATTTGATCTTGGATAATGAAGACGTTGCAATCAAGGTCTTGCGTACCAATTATCAAACAGATCAGGTAG
CAGTTGCGCGTTTCCAACGGGAAGCGCGGGCCATGGCTGAATTGAACCATCCCAATATTGTTGCCATCCGGGATATAGGC
GAAGAAGACGGACAGCAATTTTTAGTAATGGAATATGTGGATGGTGCTGACCTAAAGAGATACATTCAAAATCATGCTCC
ATTATCTAATAATGAAGTGGTTAGAATTATGGAAGAAGTCCTTTCTGCTATGACTTTAGCCCACCAAAAAGGAATTGTAC
ACAGAGATTTAAAACCTCAAAATATCCTACTAACTAAGGAGGGGGTTGTCAAAGTAACTGATTTCGGCATCGCAGTAGCC
TTTGCAGAAACAAGCTTGACACAAACTAATTCGATGTTAGGCAGTGTTCATTACTTGTCTCCAGAACAGGCTCGCGGCTC
CAAAGCGACGATTCAAAGTGATATTTATGCGATGGGGATTATGCTCTTTGAGATGTTGACAGGCCATATCCCTTATGATG
GCGATAGTGCTGTTACGATTGCCTTGCAACATTTTCAAAAGCCTCTTCCATCTATTATCGAGGAGAACCACAATGTGCCA
CAAGCTTTGGAGAATGTTGTTATTCGAGCAACAGCCAAGAAATTAAGTGATCGTTACGGGTCAACCTTTGAAATGAGTCG
TGACTTAATGACGGCGCTTAGTTATAATCGTAGTCGGGAGCGTAAGATTATCTTTGAGGATGTTGAAAGTACCAAACCCC
TCCCCAAAGTGGCCTCAGGTCCCACCGCTTCTGTAAAATTGTCTCCCCCTACCCCAACAGTGTTAACACAGGAAAGTCGA
TTAGATCAAACTAATCAAACAGATGCTTTACAGCCCCCCACCAAAAAGAAAAAAAGTGGTCGTTTTTTAGGTACTTTATT
CAAAATTCTTTTTTCTTTCTTTATTGTAGGTGTAGCACTCTTTACTTATCTTATACTAACTAAACCAACTTCTGTGAAAG
TTCCTAATGTAGCAGGCACTAGTCTTAAAGTTGCCAAACAAGAACTGTATGATGTTGGGCTAAAAGTGGGTAAAATCAGG
CAAATTGAGAGTGATACGGTTGCTGAGGGAAATGTAGTTAGAACAGATCCTAAAGCAGGAACAGCTAAGAGGCAAGGCTC
AAGCATTACGCTTTATGTGTCAATTGGAAACAAAGGTTTTGACATGGAAAACTACAAAGGACTAGATTATCAAGAAGCTA
TGAATAGTTTGATAGAAACTTATGGTGTTCCAAAATCAAAAATCAAAATTGAGCGCATTGTAACTAATGAATATCCTGAA
AATACAGTCATCAGTCAATCGCCAAGTGCGGGTGATAAATTTAATCCAAACGGAAAGTCTAAAATTACGCTCAGTGTTGC
TGTTAGTGATACGATCACTATGCCTATGGTAACAGAATATAGTTATGCAGATGCAGTCAATACCTTAACAGCTTTAGGTA
TAGATGCATCTAGAATAAAAGCTTATGTGCCAAGCTCTAGCTCAGCAACGGGCTTTGTGCCAATTCATTCTCCTAGTTCT
AAAGCTATTGTCAGTGGTCAATCCCCTTACTATGGAACGTCTTTGAGTCTGTCTGATAAAGGAGAGATTAGTCTTTACCT
TTATCCAGAAGAAACACACTCTTCTAGTAGCTCATCGAGTTCAACGTCAAGTTCAAACAGTTCTTCAACAAATGATAGTA
CTGCACCAGGTAGCAACACTGAATTAAGCCCATCAGAAACTACTTCTCAAACACCTTAA

Domains

Predicted by InterproScan.

• PASTA domain (PASTA) (372-434)

• PASTA domain (PASTA) (441-506)

• PASTA domain (PASTA) (512-588)

• Protein kinase domain (Pkinase) (12-242)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
pknB	Streptococcus mutans UA159	65.254	93.354	0.609
stkP/pknB	Streptococcus salivarius strain HSISS4	61.345	94.146	0.578
stkP	Streptococcus pneumoniae TIGR4	57.364	81.646	0.468
stkP	Streptococcus pneumoniae D39	57.171	81.646	0.467
stkP	Streptococcus pneumoniae R6	57.171	81.646	0.467
stkP	Streptococcus pneumoniae Rx1	56.977	81.646	0.465