NTDB

Overview

Name	mecA	Type	Regulator
Locus tag	IBC08_RS01065	Genome accession	NZ_CP061019
Coordinates	185957..186706 (+)	Length	249 a.a.
NCBI ID	WP_207559732.1	Uniprot ID	A0A3G6K130
Organism	Streptococcus thermophilus strain 24853
Function	degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 180957..191706

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IBC08_RS01035 (IBC08_01030)	-	181532..181702 (+)	171	WP_011680664.1	hypothetical protein	-
IBC08_RS01040 (IBC08_01035)	-	181789..181896 (+)	108	WP_011226802.1	LPXTG cell wall anchor domain-containing protein	-
IBC08_RS01045 (IBC08_01040)	-	181983..182723 (-)	741	WP_002949253.1	amino acid ABC transporter ATP-binding protein	-
IBC08_RS01050 (IBC08_01045)	-	182723..184273 (-)	1551	WP_014607891.1	ABC transporter substrate-binding protein/permease	-
IBC08_RS01055 (IBC08_01050)	-	184476..185330 (+)	855	WP_041828107.1	undecaprenyl-diphosphate phosphatase	-
IBC08_RS01060 (IBC08_01055)	-	185476..185691 (-)	216	WP_011226805.1	DUF3021 family protein	-
IBC08_RS01065 (IBC08_01060)	mecA	185957..186706 (+)	750	WP_207559732.1	adaptor protein MecA	Regulator
IBC08_RS01070 (IBC08_01065)	-	186710..187867 (+)	1158	WP_207559733.1	MraY family glycosyltransferase	-
IBC08_RS01075 (IBC08_01070)	sufC	188028..188798 (+)	771	WP_002947634.1	Fe-S cluster assembly ATPase SufC	-
IBC08_RS01080 (IBC08_01075)	sufD	188835..190097 (+)	1263	WP_011680669.1	Fe-S cluster assembly protein SufD	-
IBC08_RS01085 (IBC08_01080)	-	190153..191385 (+)	1233	WP_011225367.1	cysteine desulfurase	-

Sequence

Protein

Download Length: 249 a.a. Molecular weight: 29201.71 Da Isoelectric Point: 4.0481

                                >NTDB_id=479453 IBC08_RS01065 WP_207559732.1 185957..186706(+) (mecA) [Streptococcus thermophilus strain 24853]

MEMKQINETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL

KEDLDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAF

SDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL

PVLQATKWS

Nucleotide

Download Length: 750 bp

                                >NTDB_id=479453 IBC08_RS01065 WP_207559732.1 185957..186706(+) (mecA) [Streptococcus thermophilus strain 24853]

ATGGAAATGAAACAAATAAACGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT

GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT

TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT

AAGGAAGACCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT

TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG

ATGAGACTATGACAGAGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC

TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAATTTTATAAACTTGG

TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC

TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA

CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A3G6K130

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
mecA	Streptococcus thermophilus LMD-9	99.598	100	0.996
mecA	Streptococcus thermophilus LMG 18311	99.598	100	0.996
mecA	Streptococcus mutans UA159	57.377	97.992	0.562
mecA	Streptococcus pneumoniae Rx1	46.185	100	0.462
mecA	Streptococcus pneumoniae D39	46.185	100	0.462
mecA	Streptococcus pneumoniae R6	46.185	100	0.462
mecA	Streptococcus pneumoniae TIGR4	46.185	100	0.462

Detailed information NTG0479453