Detailed information NTG0477499

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: H7786_RS00325
• Genome accession: NZ_CP060649
• Coordinates: 52870..53781 (+)
• Length: 303 a.a.
• NCBI ID: WP_020904818.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain TSPY270
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 47870..58781

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7786_RS00305 (H7786_00310)	purE	48456..48947 (+)	492	WP_023079042.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
H7786_RS00310 (H7786_00315)	purK	48934..50007 (+)	1074	WP_030126530.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
H7786_RS00315 (H7786_00320)	-	50009..51427 (+)	1419	WP_011888524.1	hypothetical protein	-
H7786_RS00320 (H7786_00325)	purB	51447..52739 (+)	1293	WP_030126529.1	adenylosuccinate lyase	-
H7786_RS00325 (H7786_00330)	comR	52870..53781 (+)	912	WP_020904818.1	helix-turn-helix domain-containing protein	Regulator
H7786_RS00330	comS	53872..53970 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
H7786_RS00335 (H7786_00335)	ruvB	54001..54999 (+)	999	WP_011054100.1	Holliday junction branch migration DNA helicase RuvB	-
H7786_RS00340 (H7786_00340)	-	55137..55574 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
H7786_RS00345 (H7786_00345)	-	55597..55998 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
H7786_RS00350 (H7786_00350)	-	55995..57770 (+)	1776	WP_002987732.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35887.54 Da
• Isoelectric Point: 4.9349

>NTDB_id=477499 H7786_RS00325 WP_020904818.1 52870..53781(+) (comR) [Streptococcus pyogenes strain TSPY270]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDAQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=477499 H7786_RS00325 WP_020904818.1 52870..53781(+) (comR) [Streptococcus pyogenes strain TSPY270]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGCACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (12-64)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.34	100	0.993
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.157	98.68	0.465
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366