Detailed information NTG0477337

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: H7789_RS00335
• Genome accession: NZ_CP060646
• Coordinates: 53221..54132 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain TSPY1026
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48221..59132

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7789_RS00305 (H7789_00310)	purE	48383..48874 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
H7789_RS00310 (H7789_00315)	purK	48861..49934 (+)	1074	WP_194092075.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
H7789_RS00315 (H7789_00320)	-	49935..50864 (+)	930	WP_111703086.1	hypothetical protein	-
H7789_RS00320 (H7789_00325)	-	50867..51436 (+)	570	WP_032460531.1	hypothetical protein	-
H7789_RS00325 (H7789_00330)	-	51440..51802 (+)	363	WP_136019058.1	hypothetical protein	-
H7789_RS00330 (H7789_00335)	purB	51799..53091 (+)	1293	WP_038433842.1	adenylosuccinate lyase	-
H7789_RS00335 (H7789_00340)	comR	53221..54132 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
H7789_RS09335	comS	54216..54311 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
H7789_RS00340 (H7789_00345)	ruvB	54358..55356 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
H7789_RS00345 (H7789_00350)	-	55494..55931 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
H7789_RS00350 (H7789_00355)	-	55954..56355 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
H7789_RS00355 (H7789_00360)	-	56352..58127 (+)	1776	WP_002987732.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=477337 H7789_RS00335 WP_002986681.1 53221..54132(+) (comR) [Streptococcus pyogenes strain TSPY1026]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=477337 H7789_RS00335 WP_002986681.1 53221..54132(+) (comR) [Streptococcus pyogenes strain TSPY1026]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462