Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   H7796_RS00260 Genome accession   NZ_CP060640
Coordinates   47262..48173 (+) Length   303 a.a.
NCBI ID   WP_136069620.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain TSPY764     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 42262..53173
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7796_RS00240 (H7796_00245) purE 42546..43037 (+) 492 WP_228631390.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  H7796_RS00245 (H7796_00250) purK 43024..44097 (+) 1074 WP_228631391.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  H7796_RS00250 (H7796_00255) - 44124..45821 (+) 1698 WP_020904816.1 AIPR family protein -
  H7796_RS00255 (H7796_00260) purB 45839..47131 (+) 1293 WP_228631392.1 adenylosuccinate lyase -
  H7796_RS00260 (H7796_00265) comR 47262..48173 (+) 912 WP_136069620.1 transcriptional regulator Rgg4/ComR Regulator
  H7796_RS08560 comS 48257..48352 (+) 96 WP_198462994.1 quorum-sensing system DWW-type pheromone Regulator
  H7796_RS00265 (H7796_00270) ruvB 48399..49397 (+) 999 WP_063629365.1 Holliday junction branch migration DNA helicase RuvB -
  H7796_RS00270 (H7796_00275) - 49535..49972 (+) 438 WP_002994668.1 low molecular weight protein-tyrosine-phosphatase -
  H7796_RS00275 (H7796_00280) - 49995..50396 (+) 402 WP_011017240.1 MORN repeat-containing protein -
  H7796_RS00280 (H7796_00285) - 50393..52168 (+) 1776 WP_136118814.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35758.21 Da        Isoelectric Point: 4.4182

>NTDB_id=477015 H7796_RS00260 WP_136069620.1 47262..48173(+) (comR) [Streptococcus pyogenes strain TSPY764]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIEAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide


Download         Length: 912 bp        

>NTDB_id=477015 H7796_RS00260 WP_136069620.1 47262..48173(+) (comR) [Streptococcus pyogenes strain TSPY764]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AGAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

ComR tetratricopeptide (ComR_TPR)

(73-296)

Helix-turn-helix (HTH_3)

(12-64)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

99.67

100

0.997
  comR Streptococcus pyogenes MGAS315

58.667

99.01

0.581
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

51.37

96.37

0.495
  comR Streptococcus mutans UA159

46.689

99.67

0.465