Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   H7797_RS00325 Genome accession   NZ_CP060639
Coordinates   53254..54165 (+) Length   303 a.a.
NCBI ID   WP_002986681.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain TSPY153     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 48254..59165
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7797_RS00305 (H7797_00310) purE 48538..49029 (+) 492 WP_111692959.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  H7797_RS00310 (H7797_00315) purK 49016..50089 (+) 1074 WP_161230122.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  H7797_RS00315 (H7797_00320) - 50116..51813 (+) 1698 WP_111692961.1 AIPR family protein -
  H7797_RS00320 (H7797_00325) purB 51831..53123 (+) 1293 WP_020904817.1 adenylosuccinate lyase -
  H7797_RS00325 (H7797_00330) comR 53254..54165 (+) 912 WP_002986681.1 transcriptional regulator Rgg4/ComR Regulator
  H7797_RS09945 comS 54249..54344 (+) 96 WP_198462994.1 quorum-sensing system DWW-type pheromone Regulator
  H7797_RS00330 (H7797_00335) ruvB 54391..55389 (+) 999 WP_002986679.1 Holliday junction branch migration DNA helicase RuvB -
  H7797_RS00335 (H7797_00340) - 55527..55964 (+) 438 WP_002994668.1 low molecular weight protein-tyrosine-phosphatase -
  H7797_RS00340 (H7797_00345) - 55987..56388 (+) 402 WP_111692962.1 MORN repeat-containing protein -
  H7797_RS00345 (H7797_00350) - 56385..58160 (+) 1776 WP_111692963.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35757.27 Da        Isoelectric Point: 4.4858

>NTDB_id=476959 H7797_RS00325 WP_002986681.1 53254..54165(+) (comR) [Streptococcus pyogenes strain TSPY153]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide


Download         Length: 912 bp        

>NTDB_id=476959 H7797_RS00325 WP_002986681.1 53254..54165(+) (comR) [Streptococcus pyogenes strain TSPY153]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTATTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(12-64)

ComR tetratricopeptide (ComR_TPR)

(73-296)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

100

100

1
  comR Streptococcus pyogenes MGAS315

58.472

99.34

0.581
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

51.37

96.37

0.495
  comR Streptococcus mutans UA159

46.358

99.67

0.462