Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   H1R75_RS02725 Genome accession   NZ_CP059471
Coordinates   499990..501864 (+) Length   624 a.a.
NCBI ID   WP_182001609.1    Uniprot ID   -
Organism   Streptococcus equinus strain MDC1     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 494990..506864
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1R75_RS02710 (H1R75_02710) fmt 496968..497903 (+) 936 WP_074567269.1 methionyl-tRNA formyltransferase -
  H1R75_RS02715 (H1R75_02715) rsmB 497893..499215 (+) 1323 WP_182001608.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  H1R75_RS02720 (H1R75_02720) - 499253..499990 (+) 738 WP_024344649.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  H1R75_RS02725 (H1R75_02725) pknB 499990..501864 (+) 1875 WP_182001609.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  H1R75_RS02730 (H1R75_02730) liaF 502010..502705 (+) 696 WP_027968110.1 cell wall-active antibiotics response protein LiaF -
  H1R75_RS02735 (H1R75_02735) - 502702..503727 (+) 1026 WP_024344652.1 sensor histidine kinase -
  H1R75_RS02740 (H1R75_02740) - 503711..504355 (+) 645 WP_024344653.1 response regulator transcription factor -
  H1R75_RS02745 (H1R75_02745) - 504479..505879 (+) 1401 WP_182001610.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  H1R75_RS02750 (H1R75_02750) - 505879..506235 (+) 357 WP_027968108.1 S1 RNA-binding domain-containing protein -

Sequence

Protein


Download         Length: 624 a.a.        Molecular weight: 68133.92 Da        Isoelectric Point: 5.5709

>NTDB_id=469814 H1R75_RS02725 WP_182001609.1 499990..501864(+) (pknB) [Streptococcus equinus strain MDC1]
MIQIGKLFAGRYRILKSIGRGGMADVYLAKDLILDNEEVAIKVLRTNYQTDQIAVARFQREARAMAELNHPNIVSIRDIG
EEDGQQFLVMEYVDGSDLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQQGIVHRDLKPQNILLTKDGTVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENKNVP
QALENVVIKATAKRLSDRYASTFEMSRDLMTALSYNRSRERKLVFEDTENTKTLPKVTTSTPVPSTTEQLLKKQKAAKEN
KEVANQKTPKAKAKKKKSHRMFGTLMKIFFAVVVVAIAIFTYLTLSTPASVNVPDVSGAALSDAKTSLLSSGLKIGDIHK
VSSDTVAEGYVVKTDPTAGSSKKEGAKVDIYVSKGSSEFKMKDYTGQNYQDVIKELEKKHGISSKMIDIEWVTDTSYDSG
TIISQTPNEGTKVGNKDKITFEVAAITMPSLIGYTYQEAIAELNSMGVSSSHITIYMADATSSTGYSRVNSVSSSAVVVA
QDPYYGGAVEGEVNLYFSSETAAQPSEEPSQSVPESSETSETSESSSSSSSTEESSEASTEMQQ

Nucleotide


Download         Length: 1875 bp        

>NTDB_id=469814 H1R75_RS02725 WP_182001609.1 499990..501864(+) (pknB) [Streptococcus equinus strain MDC1]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGTATCCTTAAATCAATCGGACGGGGTGGAATGGCAGATGTTTA
TCTTGCCAAAGATCTGATTCTTGATAATGAAGAAGTAGCCATCAAAGTTCTTCGGACTAATTATCAAACAGATCAAATTG
CCGTAGCTCGTTTCCAACGTGAAGCGCGCGCCATGGCAGAGTTGAACCATCCCAATATTGTTTCGATTCGAGATATTGGA
GAAGAAGACGGACAGCAATTCTTAGTAATGGAATATGTTGATGGTTCTGACTTGAAAAAATACATTCAAGATCATGCGCC
TCTATCTAATAACGAAGTTGTTAGAATTATGGAAGAAGTCTTGTCAGCAATGACTCTTGCCCATCAACAAGGAATTGTTC
ACCGTGACTTAAAACCACAAAATATTTTGTTGACTAAAGACGGAACTGTAAAAGTTACTGACTTTGGTATTGCTGTAGCT
TTTGCAGAAACAAGTTTAACACAGACAAACTCAATGCTTGGTAGTGTGCATTATTTGTCACCTGAACAAGCGCGCGGTTC
AAAAGCCACTGTTCAAAGTGATATCTATGCTATGGGGATTATGTTGTTTGAAATGTTAACAGGTCATATTCCTTATGATG
GGGATTCAGCTGTTACCATTGCTTTGCAACATTTCCAAAAACCACTTCCATCAATCATTGATGAAAACAAAAATGTTCCT
CAAGCTTTGGAAAATGTAGTTATCAAAGCAACAGCAAAACGTTTAAGCGACCGTTATGCATCAACGTTTGAAATGAGTCG
TGATTTGATGACGGCACTTTCATACAACCGTAGTCGAGAACGTAAACTTGTTTTTGAGGATACAGAAAATACTAAGACAC
TTCCAAAAGTGACTACTTCAACACCTGTTCCATCAACGACAGAACAATTGTTGAAAAAACAAAAAGCTGCAAAAGAAAAT
AAAGAAGTAGCTAATCAAAAAACACCTAAAGCAAAGGCTAAAAAGAAAAAATCTCATCGTATGTTTGGTACTTTGATGAA
AATCTTCTTTGCAGTCGTTGTTGTTGCGATTGCTATCTTTACTTACTTAACTTTAAGTACACCAGCTTCAGTTAATGTTC
CAGATGTATCTGGTGCGGCTTTATCTGATGCTAAGACAAGCTTGTTATCATCTGGTTTGAAGATTGGCGATATCCACAAA
GTTTCTAGTGATACAGTTGCTGAAGGTTACGTTGTTAAAACAGATCCGACTGCTGGTTCATCTAAGAAAGAAGGAGCTAA
AGTTGATATTTATGTATCAAAAGGAAGTTCTGAATTTAAGATGAAAGATTACACTGGTCAAAATTATCAAGATGTCATCA
AGGAGCTTGAAAAGAAACATGGTATTTCAAGTAAAATGATTGATATCGAGTGGGTAACTGATACTTCATATGATAGTGGT
ACCATTATCAGCCAGACTCCTAATGAAGGGACAAAAGTTGGTAACAAAGATAAAATCACTTTTGAGGTAGCAGCAATCAC
AATGCCTAGTCTGATTGGTTATACTTACCAAGAAGCGATTGCTGAGTTAAATTCTATGGGTGTGTCAAGCTCACATATTA
CAATTTATATGGCAGATGCAACTTCATCAACAGGATACTCTCGAGTAAACTCAGTATCAAGTTCTGCGGTTGTCGTTGCT
CAGGATCCTTATTATGGTGGGGCTGTTGAAGGAGAGGTTAACCTTTACTTCTCTTCAGAAACGGCTGCACAACCATCTGA
AGAACCGTCACAATCAGTTCCAGAATCATCTGAAACAAGTGAGACAAGTGAATCAAGTTCATCAAGTAGTAGTACTGAAG
AAAGTTCAGAAGCATCTACTGAAATGCAACAATAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-247)

PASTA domain (PASTA)

(506-578)

PASTA domain (PASTA)

(371-434)

PASTA domain (PASTA)

(440-503)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

66.55

91.506

0.609
  stkP/pknB Streptococcus salivarius strain HSISS4

64.007

94.391

0.604
  stkP Streptococcus pneumoniae TIGR4

58.011

87.019

0.505
  stkP Streptococcus pneumoniae D39

57.827

87.019

0.503
  stkP Streptococcus pneumoniae R6

57.827

87.019

0.503
  stkP Streptococcus pneumoniae Rx1

57.643

87.019

0.502