Detailed information NTG0466876

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: H0I41_RS02985
• Genome accession: NZ_CP059055
• Coordinates: 648360..650519 (+)
• Length: 719 a.a.
• NCBI ID: WP_011161709.1
• Uniprot ID: Q74KI4
• Organism: Lactobacillus johnsonii strain NCK2677
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 643360..655519

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0I41_RS02975 (H0I41_02975)	-	646195..647352 (+)	1158	WP_011161707.1	RNA-guided endonuclease TnpB family protein	-
H0I41_RS02980 (H0I41_02980)	-	647550..648347 (+)	798	WP_011161708.1	LytTR family DNA-binding domain-containing protein	-
H0I41_RS02985 (H0I41_02985)	comA	648360..650519 (+)	2160	WP_011161709.1	peptide cleavage/export ABC transporter	Regulator
H0I41_RS02990 (H0I41_02990)	-	650530..651123 (+)	594	WP_011161710.1	HlyD family efflux transporter periplasmic adaptor subunit	-
H0I41_RS02995 (H0I41_02995)	-	651250..651477 (+)	228	WP_014567249.1	bacteriocin class II family protein	-
H0I41_RS03000 (H0I41_03000)	-	651488..651676 (+)	189	WP_011161712.1	Blp family class II bacteriocin	-
H0I41_RS03005 (H0I41_03005)	-	651763..652137 (+)	375	WP_011161713.1	hypothetical protein	-
H0I41_RS03010 (H0I41_03010)	-	652497..653546 (+)	1050	WP_011161461.1	IS30-like element ISLjo1 family transposase	-
H0I41_RS03015 (H0I41_03015)	-	653578..653814 (+)	237	Protein_591	peptide ABC transporter ATP-binding protein	-
H0I41_RS03020 (H0I41_03020)	-	653825..654418 (+)	594	WP_053107135.1	hypothetical protein	-
H0I41_RS03025 (H0I41_03025)	-	654568..654762 (+)	195	WP_011161718.1	hypothetical protein	-
H0I41_RS03030 (H0I41_03030)	-	654875..655165 (+)	291	WP_011161719.1	bacteriocin immunity protein	-

Sequence

Protein

• Length: 719 a.a.
• Molecular weight: 81150.53 Da
• Isoelectric Point: 7.7202

>NTDB_id=466876 H0I41_RS02985 WP_011161709.1 648360..650519(+) (comA) [Lactobacillus johnsonii strain NCK2677]
MLFKYKSVYVPQVDEMDCGVACLAMILKQYHSRISLAHLRHEARTNLEGTTALGLVKTAQKFNLKTEAVKADMSLFNDDG
IQYPFIAHVLKQGELLHYYVVLKNTKNYLLIADPDPSVGVIKMPKDRFAQEWTGIALFMVPNENFEPIKEKKNNLWSLFP
YMFKQKRLMINIILAALLMTIISICSSYFVQGIIDTYIPSGTYQTLSILAVGLLIAYVFNSIFSYGQNFLLNVLGQRLSI
DLNLQYIRHIFELPMEFFVTRRTGEITSRFSDASRIIDALASTVISLFLDLSIVIVMGLVLAAQSMTLFGITLLALPIYA
VVILGFTKKFEKLNNEQMESNAVLSSSVIEDIQGIETIKALNSENTRYRRIDSQFVDYLKKSFKYSKTESLQTALKTFIQ
LSLNVIILWVGAKVVMQGQLSIGQLMTFNALLAYFIDPLQNIINLQPRLQSASVAQNRLNEVYQVKSEFNQKTAIEDCKL
LEGNIEYKNVDYRYGYGADVLKDINLKINQGEKLTIVGMSGSGKSTMVKLLVDFFSPSKGQVILNGHATSEINKHSLRSY
VNYVPQTPYIFSGTVRENLLLGCRPDITEEDVIEACQIAEIDQEIANLPLQFETKLDENAKILSGGQKQRLTIARALLSP
AKVFIFDEVTSGLDTITEKRVIDNLMKLKDKTIIFIAHRLAIAERADKVVVIDRGQIVEEGSHSELMNMHGFYYDLVKG

Nucleotide

• Length: 2160 bp

>NTDB_id=466876 H0I41_RS02985 WP_011161709.1 648360..650519(+) (comA) [Lactobacillus johnsonii strain NCK2677]
ATGTTATTCAAATATAAATCTGTTTATGTACCTCAAGTAGATGAGATGGATTGCGGAGTTGCTTGTTTAGCGATGATCTT
AAAACAATATCATTCTCGTATATCTTTAGCTCATTTACGTCATGAAGCGCGTACTAATCTTGAAGGAACAACTGCTTTAG
GGTTAGTTAAAACAGCCCAGAAATTTAATTTAAAAACAGAAGCCGTAAAGGCAGATATGTCTTTATTTAATGATGACGGT
ATTCAGTATCCTTTTATTGCTCACGTACTTAAACAGGGAGAATTGCTTCACTATTATGTGGTGCTAAAAAATACTAAAAA
TTATTTATTAATTGCCGATCCAGATCCTTCAGTTGGTGTGATAAAAATGCCTAAAGATAGGTTCGCTCAAGAATGGACAG
GGATTGCACTCTTTATGGTTCCCAATGAAAACTTTGAACCAATTAAAGAAAAGAAGAATAACCTATGGTCTCTCTTTCCA
TATATGTTTAAACAAAAGCGGCTAATGATTAATATCATTCTAGCCGCTTTATTAATGACCATAATTAGTATCTGTAGTTC
ATATTTTGTTCAAGGAATAATTGATACTTATATTCCAAGTGGTACTTATCAGACTTTATCAATCTTAGCAGTCGGATTGT
TAATTGCTTATGTCTTTAATTCTATCTTCTCCTATGGACAGAATTTTTTGCTAAATGTTTTAGGACAAAGATTAAGTATT
GATTTAAATCTTCAATATATTAGACATATTTTTGAATTACCGATGGAATTTTTTGTAACAAGAAGAACGGGTGAAATTAC
TTCACGTTTTTCTGATGCAAGTAGAATTATTGATGCTTTGGCAAGTACGGTTATCTCGCTTTTCTTAGATCTATCAATTG
TAATCGTAATGGGATTAGTATTAGCGGCTCAGAGTATGACTTTGTTTGGAATCACATTATTGGCTTTACCTATTTATGCA
GTTGTAATTCTAGGTTTTACTAAAAAGTTTGAAAAATTAAATAATGAGCAAATGGAAAGTAATGCTGTTTTGAGTTCTTC
AGTTATTGAAGACATTCAAGGAATTGAAACAATTAAAGCATTAAATAGTGAGAATACAAGGTATAGAAGAATCGATAGTC
AGTTTGTAGATTACTTAAAAAAATCTTTTAAATACAGCAAAACTGAGAGCTTGCAGACAGCACTCAAGACATTTATTCAA
TTATCTCTTAATGTAATTATTCTTTGGGTTGGTGCAAAAGTTGTAATGCAAGGACAATTGAGCATTGGTCAGTTGATGAC
TTTTAATGCGTTGCTGGCATATTTTATTGATCCACTGCAAAATATTATTAATCTGCAACCGCGACTTCAATCAGCTAGTG
TTGCTCAAAATCGATTGAATGAGGTCTATCAAGTAAAAAGTGAATTCAATCAGAAGACTGCTATTGAAGATTGTAAGCTC
CTAGAAGGAAATATTGAATATAAGAATGTGGATTATCGCTATGGTTATGGTGCAGATGTCTTAAAAGATATTAATCTAAA
AATTAACCAGGGCGAAAAATTAACGATTGTTGGAATGAGTGGATCTGGAAAATCAACAATGGTTAAGTTGTTAGTAGATT
TCTTTTCGCCAAGTAAGGGTCAAGTCATTTTAAATGGCCATGCAACAAGTGAGATTAATAAGCATAGCTTGCGATCATAT
GTGAATTATGTACCTCAAACCCCATATATCTTTTCTGGAACAGTTAGAGAGAATTTGTTGTTAGGTTGTAGGCCAGATAT
CACTGAAGAAGATGTAATAGAGGCTTGTCAGATTGCTGAGATTGACCAAGAAATAGCTAATCTACCTTTGCAATTTGAAA
CAAAATTAGATGAAAATGCAAAAATTCTATCTGGTGGACAAAAACAAAGGTTAACAATTGCTCGGGCATTATTATCTCCT
GCAAAGGTATTTATCTTTGATGAAGTAACAAGTGGCTTAGATACAATTACTGAGAAGAGAGTAATTGATAATTTGATGAA
GCTCAAAGATAAGACAATTATTTTTATCGCACACCGTCTGGCAATTGCGGAACGAGCAGATAAGGTTGTTGTAATTGATC
GTGGCCAGATAGTTGAAGAAGGCAGTCACAGCGAATTGATGAATATGCATGGCTTTTATTATGACTTAGTGAAGGGATAG

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-143)

• ABC transporter transmembrane region (ABC_membrane) (169-439)

• ABC transporter (ABC_tran) (501-651)

3D structure

• AlphaFold DB: Q74KI4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	57.303	99.026	0.567
comA	Streptococcus mitis SK321	57.022	99.026	0.565
comA	Streptococcus pneumoniae Rx1	56.882	99.026	0.563
comA	Streptococcus pneumoniae D39	56.882	99.026	0.563
comA	Streptococcus pneumoniae R6	56.882	99.026	0.563
comA	Streptococcus pneumoniae TIGR4	56.742	99.026	0.562
comA	Streptococcus gordonii str. Challis substr. CH1	55.758	99.026	0.552
comA/nlmT	Streptococcus mutans UA159	53.324	98.331	0.524