Detailed information NTG0463949

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: HYD32_RS00340
• Genome accession: NZ_CP058345
• Coordinates: 48888..51035 (-)
• Length: 715 a.a.
• NCBI ID: WP_072612877.1
• Uniprot ID: A0A2N9KH43
• Organism: Leuconostoc sp. MTCC 10508
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 43888..56035

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HYD32_RS00320	-	45080..45667 (+)	588	WP_072612874.1	helix-turn-helix domain-containing protein	-
HYD32_RS00325	-	45725..46462 (+)	738	WP_248574682.1	SDR family NAD(P)-dependent oxidoreductase	-
HYD32_RS00330	-	46577..46702 (+)	126	WP_011679061.1	putative metal homeostasis protein	-
HYD32_RS00335	-	47521..48870 (-)	1350	WP_072612876.1	bacteriocin secretion accessory protein	-
HYD32_RS00340	comA	48888..51035 (-)	2148	WP_072612877.1	peptide cleavage/export ABC transporter	Regulator
HYD32_RS00345	-	51724..51924 (+)	201	WP_072612878.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
HYD32_RS00350	-	51917..52081 (+)	165	WP_072612879.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
HYD32_RS00355	-	52667..52843 (+)	177	WP_072612880.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
HYD32_RS00360	-	52873..53034 (+)	162	WP_072612881.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
HYD32_RS00365	-	53654..53833 (+)	180	WP_072612883.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
HYD32_RS00370	-	53847..54020 (+)	174	WP_072612884.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
HYD32_RS00375	-	54510..55235 (-)	726	WP_072612886.1	response regulator transcription factor	-

Sequence

Protein

• Length: 715 a.a.
• Molecular weight: 80324.21 Da
• Isoelectric Point: 9.1311

>NTDB_id=463949 HYD32_RS00340 WP_072612877.1 48888..51035(-) (comA) [Leuconostoc sp. MTCC 10508]
MRKFHYISQLEEKDCGVAALAMILKRHGSDVSLANIRERCQTSLSGTTALGLVKAAESFNMDVRPIQADLTLFEMKDLPL
PFIAHVEKKGQYLHYYVVYGFTKNKVIIADPDPTVGKTAMTLQEFSKEWTGVALFMSPSPKYKPFKENKNSILSFLPIIS
RQKGLIANIVAASLLVTLISIAGSYYMQLVIDAYIPSAMSNTLTVVSLGLITTYVLQQLLSFARTYLLTIMGQRLSIEVI
LSYIRHLFELPVNFFATRRTGEIVTRFNDANTIIDAMANTILSLFLDLGITIIVGSVLAIQNTKLFLLSLISFPIYFLIV
YCFMKPFERLNQEQMASNATLSSSIIEDINGIETIKSLTSEKTSYQKIDREFVDYLKKSFAHQKSEAIQNSIKQATQLII
NVFILWLGAKLVISNQISVGQLVTYNALLGYFTEPFQNIINLQAKLQTATVANRRLNEVYLVKSEFKKSESQELHHNNPH
NITVDDVSYQYGYQKNILHHFSIKIPFGEKVALVGVSGSGKSTLAKLLVNFISPSAGNIFIGEQNIKHVQRQNLRQHILY
LPQNPYIFTGSILDNLTLGARENTTQEDILHAVELADIKDDIENMPQSYQTEISEEGGMSGGQKQRIALARALLSNSQIL
ILDESTSNLDVATEKKIIDNLLSLKNKTIIFIAHRLTIAEKVQRVILLEKGIISEDGSHAELIHKKSKYYHLVKH

Nucleotide

• Length: 2148 bp

>NTDB_id=463949 HYD32_RS00340 WP_072612877.1 48888..51035(-) (comA) [Leuconostoc sp. MTCC 10508]
ATGAGAAAGTTTCATTATATATCACAACTTGAAGAAAAAGATTGTGGCGTAGCAGCACTAGCTATGATTTTAAAGCGACA
CGGCTCAGATGTTTCATTAGCTAACATTCGCGAACGCTGTCAAACATCTTTATCAGGTACAACGGCGTTAGGCTTAGTGA
AAGCCGCTGAATCATTTAATATGGATGTCCGTCCAATTCAAGCTGACTTGACTTTGTTCGAAATGAAAGATTTACCTCTG
CCGTTTATCGCTCATGTTGAGAAAAAAGGTCAATACTTACATTATTATGTAGTGTACGGATTCACTAAAAACAAAGTTAT
TATTGCAGATCCAGATCCAACAGTTGGTAAAACCGCAATGACGTTACAGGAATTCTCCAAAGAGTGGACTGGGGTAGCAT
TGTTCATGTCGCCTTCACCCAAATATAAACCTTTTAAAGAAAATAAAAACAGTATCCTATCCTTTTTACCAATTATTAGC
CGACAAAAAGGATTAATTGCTAATATTGTCGCCGCTTCTTTGCTAGTCACCTTAATTAGTATCGCTGGTTCTTATTACAT
GCAACTAGTGATCGATGCCTATATTCCTAGTGCTATGTCTAACACATTAACCGTTGTTTCATTAGGGCTCATTACGACTT
ATGTGTTACAACAACTACTTAGTTTTGCTCGAACCTATTTGTTAACTATTATGGGACAACGATTATCGATTGAAGTCATA
CTATCATACATACGTCACTTGTTCGAACTGCCTGTTAATTTCTTTGCCACACGTCGAACAGGTGAAATTGTAACGCGTTT
TAATGACGCCAATACCATTATTGATGCCATGGCAAATACAATTCTCTCACTTTTTTTAGATTTAGGGATCACGATAATTG
TTGGCAGCGTCTTAGCAATTCAAAATACAAAACTTTTTCTACTATCTCTAATCTCTTTCCCTATCTACTTCTTGATTGTC
TACTGTTTCATGAAGCCATTTGAACGATTGAATCAAGAACAGATGGCAAGTAATGCAACACTGAGCTCCTCTATTATTGA
AGACATCAATGGTATTGAAACCATAAAATCTTTGACAAGTGAGAAGACAAGCTATCAAAAAATTGATCGTGAATTTGTTG
ATTATTTAAAAAAATCCTTTGCCCATCAAAAAAGCGAAGCCATTCAAAATAGTATTAAACAAGCAACTCAACTCATTATC
AATGTATTCATTTTATGGTTGGGCGCCAAGCTAGTGATTAGTAATCAAATTAGTGTCGGTCAGTTAGTTACTTATAATGC
ATTACTAGGCTACTTTACTGAACCTTTCCAAAATATTATTAACTTGCAGGCGAAATTACAAACGGCAACGGTTGCTAACC
GACGATTAAACGAAGTCTATCTTGTAAAATCAGAGTTTAAAAAATCAGAATCGCAAGAGCTTCATCATAATAACCCTCAT
AATATTACAGTTGACGACGTCAGCTATCAATATGGTTATCAAAAGAACATATTACACCACTTTTCAATTAAGATTCCCTT
TGGTGAAAAAGTTGCTCTGGTCGGTGTTAGTGGTTCCGGTAAGTCAACATTAGCCAAACTACTTGTTAATTTTATATCAC
CTAGTGCTGGAAACATTTTTATTGGTGAACAAAACATTAAACACGTTCAACGCCAAAATTTAAGACAACATATTCTTTAT
CTACCACAAAACCCATACATATTTACTGGAAGCATATTAGATAACTTAACACTAGGTGCTCGTGAAAATACAACACAAGA
AGACATCCTACATGCTGTTGAGCTTGCTGACATTAAAGACGACATCGAAAATATGCCACAAAGTTATCAAACCGAAATTT
CAGAGGAAGGCGGCATGTCTGGAGGCCAAAAGCAGCGTATCGCTTTAGCTAGAGCCCTCCTTAGTAATTCTCAAATACTT
ATTTTGGATGAATCAACCAGTAATCTTGATGTCGCAACTGAAAAAAAGATTATTGATAATTTATTATCGCTTAAAAATAA
GACAATCATTTTTATTGCACATCGCCTGACCATTGCTGAAAAAGTCCAACGTGTTATTCTACTTGAAAAAGGGATCATCA
GTGAAGATGGTAGCCATGCTGAACTTATACATAAAAAATCAAAATACTATCATCTTGTAAAGCATTAA

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (169-436)

• Peptidase C39 family (Peptidase_C39) (3-140)

• ABC transporter (ABC_tran) (498-647)

3D structure

• AlphaFold DB: A0A2N9KH43

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus gordonii str. Challis substr. CH1	59.804	99.86	0.597
comA	Streptococcus mitis NCTC 12261	58.708	99.58	0.585
comA	Streptococcus mitis SK321	58.427	99.58	0.582
comA	Streptococcus pneumoniae D39	58.146	99.58	0.579
comA	Streptococcus pneumoniae Rx1	58.146	99.58	0.579
comA	Streptococcus pneumoniae R6	58.146	99.58	0.579
comA	Streptococcus pneumoniae TIGR4	57.865	99.58	0.576
comA/nlmT	Streptococcus mutans UA159	54.712	99.441	0.544