Detailed information    

insolico Bioinformatically predicted

Overview


Name   htrA   Type   Regulator
Locus tag   HU262_RS10025 Genome accession   NZ_CP055229
Coordinates   2177100..2178386 (+) Length   428 a.a.
NCBI ID   WP_010737045.1    Uniprot ID   A0A2A4DST9
Organism   Enterococcus hirae strain 13344     
Function   require for competence development (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 2141434..2210232 2177100..2178386 within 0


Gene organization within MGE regions


Location: 2141434..2210232
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HU262_RS09860 (HU262_09860) - 2141784..2141996 (-) 213 WP_010720912.1 hypothetical protein -
  HU262_RS09865 (HU262_09865) - 2142243..2142584 (-) 342 WP_010720913.1 YlbF family regulator -
  HU262_RS09870 (HU262_09870) - 2142650..2144821 (-) 2172 WP_081123626.1 PBP1A family penicillin-binding protein -
  HU262_RS09875 (HU262_09875) - 2145029..2145883 (+) 855 WP_010737061.1 RluA family pseudouridine synthase -
  HU262_RS09880 (HU262_09880) - 2145986..2146846 (-) 861 WP_034700407.1 ROK family protein -
  HU262_RS09885 (HU262_09885) - 2146850..2149531 (-) 2682 WP_010737059.1 alpha-mannosidase -
  HU262_RS09890 (HU262_09890) - 2149542..2150843 (-) 1302 WP_010737058.1 glycoside hydrolase family 125 protein -
  HU262_RS09895 (HU262_09895) - 2150998..2152044 (+) 1047 WP_081125619.1 substrate-binding domain-containing protein -
  HU262_RS09900 (HU262_09900) - 2151992..2154196 (+) 2205 WP_071859334.1 GH92 family glycosyl hydrolase -
  HU262_RS09905 (HU262_09905) - 2154302..2154625 (-) 324 WP_010737055.1 hypothetical protein -
  HU262_RS09910 (HU262_09910) - 2154639..2155556 (-) 918 WP_010737054.1 hypothetical protein -
  HU262_RS09915 (HU262_09915) - 2155819..2156871 (-) 1053 WP_010720927.1 PTS sugar transporter subunit IIC -
  HU262_RS09920 (HU262_09920) - 2156885..2157823 (-) 939 WP_010720928.1 2-dehydropantoate 2-reductase -
  HU262_RS09925 (HU262_09925) - 2158161..2160059 (-) 1899 WP_010737053.1 BglG family transcription antiterminator -
  HU262_RS09930 (HU262_09930) - 2160173..2161231 (-) 1059 Protein_1956 glycoside hydrolase family 1 protein -
  HU262_RS09935 (HU262_09935) - 2161288..2161968 (-) 681 WP_002331383.1 IS6-like element IS1216 family transposase -
  HU262_RS09940 (HU262_09940) - 2162043..2162540 (-) 498 Protein_1958 N-acetylmannosamine-6-phosphate 2-epimerase -
  HU262_RS09945 (HU262_09945) - 2162704..2163522 (+) 819 WP_081125614.1 MurR/RpiR family transcriptional regulator -
  HU262_RS09950 (HU262_09950) - 2163563..2163802 (-) 240 WP_081125613.1 hypothetical protein -
  HU262_RS09955 (HU262_09955) - 2164831..2165883 (-) 1053 WP_053765601.1 FUSC family protein -
  HU262_RS09960 (HU262_09960) - 2166132..2166710 (-) 579 Protein_1962 peptidoglycan DD-metalloendopeptidase family protein -
  HU262_RS09970 (HU262_09970) - 2168342..2168515 (-) 174 WP_162783193.1 hypothetical protein -
  HU262_RS09975 (HU262_09975) - 2168508..2168801 (-) 294 WP_002296258.1 Mor transcription activator family protein -
  HU262_RS09980 (HU262_09980) - 2168947..2169498 (-) 552 WP_002296259.1 DUF1643 domain-containing protein -
  HU262_RS09985 (HU262_09985) - 2169672..2169971 (-) 300 WP_002389983.1 4'-phosphopantetheinyl transferase -
  HU262_RS09990 (HU262_09990) - 2169998..2170306 (-) 309 WP_002317115.1 DUF960 domain-containing protein -
  HU262_RS09995 (HU262_09995) - 2170527..2171204 (+) 678 Protein_1969 IS6-like element IS1216 family transposase -
  HU262_RS10000 (HU262_10000) clpL 2171325..2173439 (-) 2115 WP_002335148.1 ATP-dependent protease ClpL -
  HU262_RS10005 (HU262_10005) - 2173711..2174394 (+) 684 WP_178309305.1 PHP domain-containing protein -
  HU262_RS10010 (HU262_10010) - 2174431..2174928 (-) 498 WP_002316138.1 GNAT family N-acetyltransferase -
  HU262_RS10015 (HU262_10015) - 2174984..2175892 (-) 909 WP_002332708.1 IS982-like element ISEfm1 family transposase -
  HU262_RS10020 (HU262_10020) rlmH 2176168..2176647 (-) 480 WP_002317110.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  HU262_RS10025 (HU262_10025) htrA 2177100..2178386 (+) 1287 WP_010737045.1 S1C family serine protease Regulator
  HU262_RS10030 (HU262_10030) ytpR 2178444..2179049 (-) 606 WP_010737044.1 YtpR family tRNA-binding protein -
  HU262_RS10035 (HU262_10035) - 2179358..2179825 (-) 468 WP_002317107.1 universal stress protein -
  HU262_RS10040 (HU262_10040) - 2179855..2180175 (-) 321 Protein_1978 thioredoxin family protein -
  HU262_RS10045 (HU262_10045) pepA 2180712..2181791 (-) 1080 WP_010720947.1 glutamyl aminopeptidase -
  HU262_RS10050 (HU262_10050) - 2181990..2182343 (+) 354 WP_002317104.1 PepSY domain-containing protein -
  HU262_RS10055 (HU262_10055) - 2182515..2183471 (+) 957 WP_178309306.1 glycosyltransferase family 2 protein -
  HU262_RS10060 (HU262_10060) - 2183547..2185004 (-) 1458 WP_094940324.1 NAD-dependent succinate-semialdehyde dehydrogenase -
  HU262_RS10065 (HU262_10065) - 2185299..2186177 (+) 879 WP_010737041.1 cation diffusion facilitator family transporter -
  HU262_RS10070 (HU262_10070) - 2186241..2188111 (-) 1871 Protein_1984 glycosyltransferase -
  HU262_RS10075 (HU262_10075) - 2188283..2189587 (-) 1305 WP_010720951.1 glycosyltransferase -
  HU262_RS10080 (HU262_10080) - 2189611..2190096 (-) 486 WP_081123419.1 hypothetical protein -
  HU262_RS10085 (HU262_10085) - 2190389..2192524 (-) 2136 WP_081123420.1 UvrD-helicase domain-containing protein -
  HU262_RS10090 (HU262_10090) - 2192600..2194255 (-) 1656 WP_010737035.1 FAD-dependent oxidoreductase -
  HU262_RS10095 (HU262_10095) - 2194256..2194567 (-) 312 WP_010737034.1 rhodanese-like domain-containing protein -
  HU262_RS10100 (HU262_10100) - 2194738..2194998 (+) 261 WP_010737033.1 metal-sensitive transcriptional regulator -
  HU262_RS10105 (HU262_10105) - 2195011..2195322 (+) 312 WP_010737032.1 DsrE family protein -
  HU262_RS10110 (HU262_10110) - 2195464..2196012 (-) 549 WP_034867944.1 CDP-alcohol phosphatidyltransferase family protein -
  HU262_RS10115 (HU262_10115) - 2196216..2198114 (-) 1899 WP_178309307.1 endonuclease MutS2 -
  HU262_RS10120 (HU262_10120) - 2198626..2199342 (-) 717 WP_010720960.1 MIP/aquaporin family protein -
  HU262_RS10125 (HU262_10125) glpO 2199343..2201166 (-) 1824 WP_178309308.1 type 1 glycerol-3-phosphate oxidase -
  HU262_RS10130 (HU262_10130) glpK 2201181..2202677 (-) 1497 WP_010720962.1 glycerol kinase GlpK -
  HU262_RS10135 (HU262_10135) - 2202790..2204250 (-) 1461 WP_010737027.1 helix-turn-helix domain-containing protein -
  HU262_RS10140 (HU262_10140) - 2204240..2205535 (-) 1296 WP_010737026.1 FAD-dependent oxidoreductase -
  HU262_RS10145 (HU262_10145) - 2205759..2206352 (-) 594 WP_178309309.1 hypothetical protein -
  HU262_RS10150 (HU262_10150) - 2206674..2207495 (-) 822 WP_010737024.1 hypothetical protein -
  HU262_RS10155 (HU262_10155) - 2207841..2208518 (-) 678 WP_010737023.1 type 1 glutamine amidotransferase domain-containing protein -
  HU262_RS10160 (HU262_10160) - 2208554..2209660 (-) 1107 WP_178309310.1 NADH-dependent flavin oxidoreductase -
  HU262_RS10165 (HU262_10165) - 2209740..2210174 (-) 435 WP_010720971.1 MarR family winged helix-turn-helix transcriptional regulator -

Sequence


Protein


Download         Length: 428 a.a.        Molecular weight: 44581.68 Da        Isoelectric Point: 4.7976

>NTDB_id=456997 HU262_RS10025 WP_010737045.1 2177100..2178386(+) (htrA) [Enterococcus hirae strain 13344]
MERKDVTPKMKKNNGIWRKLGLGLVGGIIGGLVTAGIFYAVMGSGNAASNSGGHQNSAGETVVENVKVNVDSDITNAVDK
VQDAVVSVINLQSQNQGTNGFGQLFGQQQQESSDDSNLEASSEGSGVIYKKSGNSAYIVTNNHVVEGQQGLEVLLKDGTK
VKAELVGTDAYSDLAVLKISADKVNKVASFGDSNSLKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNQTVN
INAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSASSSGVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGITM
VDLSAVSTQQQEQILKIPESVTNGVIVTSVQPATPAEKAGLKQYDVITKIDDTDVSSGVELQSVLYQKKVGDSVKVTYYR
GKEKKTTTIQLTIDQSALKQSQSENSGN

Nucleotide


Download         Length: 1287 bp        

>NTDB_id=456997 HU262_RS10025 WP_010737045.1 2177100..2178386(+) (htrA) [Enterococcus hirae strain 13344]
ATGGAGAGAAAAGATGTGACACCAAAAATGAAAAAGAATAATGGAATCTGGCGTAAGCTGGGTCTAGGCTTAGTCGGTGG
AATTATTGGGGGCTTGGTAACGGCTGGTATTTTTTATGCTGTCATGGGTTCTGGAAACGCAGCGTCAAATTCGGGTGGTC
ATCAAAATTCAGCGGGCGAAACTGTCGTTGAGAATGTCAAAGTCAATGTCGATTCAGATATTACGAATGCGGTCGATAAA
GTCCAAGATGCGGTGGTATCTGTTATCAATCTTCAAAGCCAAAATCAAGGGACCAACGGCTTTGGGCAACTGTTTGGCCA
ACAACAACAAGAAAGTTCTGATGATAGCAACCTAGAGGCTTCTAGTGAAGGTAGTGGTGTCATCTACAAAAAAAGTGGTA
ATTCCGCTTATATCGTAACGAATAATCACGTAGTGGAAGGCCAACAAGGATTAGAAGTTTTATTAAAAGATGGAACAAAA
GTCAAAGCTGAATTAGTCGGGACGGATGCTTATTCTGACTTAGCCGTTTTGAAAATCAGTGCAGATAAAGTGAACAAAGT
TGCTTCATTTGGTGACTCTAATTCATTGAAAGTAGGTGAACCGGCGATCGCAATTGGTTCTCCTTTAGGTTCTGAATATG
CCAACTCTGTGACTTCTGGGATTATCTCTTCATTGAATCGCCAAGTAACCAGCACGAACGAGTCAAATCAAACGGTCAAT
ATCAATGCGATCCAAACAGATGCTGCGATCAACCCTGGTAATTCTGGTGGTCCATTAGTTAATATCGAAGGTCAAGTGAT
CGGGATCAATTCAAGTAAAATTGCAAGTACTTCTGCTTCTTCATCAGGTGTAAGCGTGGAAGGAATGGGCTTTGCGATCC
CAAGTAACGATGTAGTAAATATTATCAACCAACTTGAAAAAGATGGAAAAGTAACCCGTCCTGCTCTAGGGATCACAATG
GTTGACCTTTCAGCCGTTTCAACCCAACAACAAGAACAAATCTTGAAAATTCCTGAATCTGTGACAAATGGTGTGATTGT
TACCAGCGTTCAACCGGCGACACCTGCAGAAAAAGCTGGCTTGAAACAATATGATGTCATTACAAAAATCGATGATACTG
ATGTTTCTTCTGGTGTAGAATTACAATCTGTCTTGTATCAGAAAAAAGTCGGCGATTCAGTGAAGGTCACTTACTATCGC
GGAAAAGAAAAGAAAACAACAACAATTCAATTAACAATTGATCAATCCGCATTAAAACAAAGCCAATCAGAGAACTCTGG
TAACTAA


Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB A0A2A4DST9

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

54.545

92.523

0.505

  htrA Streptococcus gordonii str. Challis substr. CH1

53.35

94.159

0.502

  htrA Streptococcus pneumoniae Rx1

58.457

78.738

0.46

  htrA Streptococcus pneumoniae D39

58.457

78.738

0.46

  htrA Streptococcus pneumoniae R6

58.457

78.738

0.46

  htrA Streptococcus pneumoniae TIGR4

58.457

78.738

0.46

  htrA Streptococcus mitis NCTC 12261

57.567

78.738

0.453