NTDB

Overview

Name	comE/blpR	Type	Regulator
Locus tag	I6H74_RS02870	Genome accession	NZ_CP066069
Coordinates	558238..558978 (+)	Length	246 a.a.
NCBI ID	WP_003061418.1	Uniprot ID	Q8KQN2
Organism	Streptococcus dysgalactiae strain FDAARGOS_1017
Function	activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 553238..563978

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6H74_RS02855 (I6H74_02850)	gltX	553544..554992 (+)	1449	WP_003053372.1	glutamate--tRNA ligase	-
I6H74_RS02860 (I6H74_02855)	-	555607..556950 (+)	1344	WP_115257033.1	GHKL domain-containing protein	-
I6H74_RS02865 (I6H74_02860)	-	556951..558234 (+)	1284	WP_084916681.1	sensor histidine kinase	-
I6H74_RS02870 (I6H74_02865)	comE/blpR	558238..558978 (+)	741	WP_003061418.1	LytTR family DNA-binding domain-containing protein	Regulator
I6H74_RS02875 (I6H74_02870)	rnpA	559520..559879 (+)	360	WP_003056083.1	ribonuclease P protein component	-
I6H74_RS02880 (I6H74_02875)	-	559845..560672 (+)	828	WP_100249539.1	YidC/Oxa1 family membrane protein insertase	-
I6H74_RS02885 (I6H74_02880)	jag	560684..561598 (+)	915	WP_003056081.1	RNA-binding cell elongation regulator Jag/EloR	-
I6H74_RS02890 (I6H74_02885)	rpmH	561911..562045 (+)	135	WP_002885866.1	50S ribosomal protein L34	-
I6H74_RS02895 (I6H74_02890)	-	562376..563080 (+)	705	WP_003056091.1	N-acetylmannosamine-6-phosphate 2-epimerase	-

Sequence

Protein

Download Length: 246 a.a. Molecular weight: 28977.28 Da Isoelectric Point: 4.8645

                                >NTDB_id=453534 I6H74_RS02870 WP_003061418.1 558238..558978(+) (comE/blpR) [Streptococcus dysgalactiae strain FDAARGOS_1017]

MMNIFILEDDFIQQTRIESVVADILEEAKIPCNQLEVFANPHKLFESIQERGDHQLYFLDIEIGDEDRRGLELAADIRQK

DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAVDKQQFRDQIEECIRYTYEMMSSRESEDMFLFETPQTRLKLPYKDIL

YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFDNGDSCMVSRLKMKCLFE

KWEALH

Nucleotide

Download Length: 741 bp

                                >NTDB_id=453534 I6H74_RS02870 WP_003061418.1 558238..558978(+) (comE/blpR) [Streptococcus dysgalactiae strain FDAARGOS_1017]

ATGATGAATATTTTTATTCTTGAAGATGATTTTATCCAACAGACACGTATTGAATCTGTAGTGGCAGACATCTTGGAAGA

AGCTAAAATCCCTTGTAATCAGCTAGAAGTGTTTGCCAATCCTCATAAATTATTTGAAAGCATTCAAGAAAGAGGCGATC

ACCAGCTATATTTTTTAGACATTGAGATTGGTGATGAGGATCGCCGAGGGCTTGAATTGGCAGCAGATATTCGACAAAAA

GACCCCAATGCGGTCATTGTGTTTGTTACCACACATTCTGAATTTGCTCCTATTTCTTTTAAATACAAAGTGTCTGCCTT

AGATTTTATTGACAAAGCAGTTGATAAACAACAATTTAGGGATCAGATTGAAGAATGTATCCGCTATACCTATGAGATGA

TGTCTAGCCGAGAATCAGAAGACATGTTTTTATTTGAGACCCCTCAGACAAGGTTAAAATTACCTTACAAAGATATCCTT

TATTTTGCTACTGCTACGACACCCCACAAGGTGTGTTTGTGGACTCAGACGGAGAGACTGGAGTTTTATGGTAATTTATC

TGAGATACAAGCTGTGGCTCCAAAGCTTTTCTTATGCCATAGATCTTACTTGGTTAATCTAGATAAGGTTGTGCGTATTG

ATAAATCCAAACAGCTCCTCTATTTCGATAATGGGGATTCCTGTATGGTCTCACGCTTAAAAATGAAATGCCTTTTTGAA

AAATGGGAAGCCTTACATTAA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-123)

LytTr DNA-binding domain (LytTR)

(152-242)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	Q8KQN2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comE/blpR	Streptococcus mutans UA159	47.699	97.154	0.463
comE/comE1	Streptococcus equinus JB1	42.437	96.748	0.411
comE/comE2	Streptococcus equinus JB1	40.408	99.593	0.402
comE/comE2	Streptococcus gordonii strain NCTC7865	39.113	100	0.394
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	39.113	100	0.394

Detailed information NTG0453534