Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   FOC72_RS00990 Genome accession   NZ_CP054570
Coordinates   200446..201198 (+) Length   250 a.a.
NCBI ID   WP_002893638.1    Uniprot ID   A0A859ELL8
Organism   Streptococcus sanguinis strain FDAARGOS_770     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 195446..206198
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FOC72_RS00975 (FOC72_00975) - 195696..197261 (-) 1566 WP_002893643.1 ABC transporter substrate-binding protein/permease -
  FOC72_RS00980 (FOC72_00980) - 197393..199288 (+) 1896 WP_002893641.1 DUF2207 domain-containing protein -
  FOC72_RS00985 (FOC72_00985) - 199428..200270 (+) 843 WP_002893640.1 undecaprenyl-diphosphate phosphatase -
  FOC72_RS00990 (FOC72_00990) mecA 200446..201198 (+) 753 WP_002893638.1 adaptor protein MecA Regulator
  FOC72_RS00995 (FOC72_00995) - 201189..202355 (+) 1167 WP_002893637.1 glycosyltransferase family 4 protein -
  FOC72_RS01000 (FOC72_01000) sufC 202445..203215 (+) 771 WP_002893635.1 Fe-S cluster assembly ATPase SufC -
  FOC72_RS01005 (FOC72_01005) sufD 203257..204519 (+) 1263 WP_002893634.1 Fe-S cluster assembly protein SufD -
  FOC72_RS01010 (FOC72_01010) - 204561..205793 (+) 1233 WP_002893633.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 28754.33 Da        Isoelectric Point: 3.9621

>NTDB_id=453473 FOC72_RS00990 WP_002893638.1 200446..201198(+) (mecA) [Streptococcus sanguinis strain FDAARGOS_770]
MEMKQISDSTIKITIQLEDLEERGMEMADFLVPQEKTEEFFYTILDELEMPDNFLDSGMLSFRVTPKPDKVDVFVTKSKL
DKNLSFEDLADLPDMDELSHMSPDEFLKTLEKSIFEKSKEDIEAVQSLETAEAEEGEQLSQEAADEQSAENAERYIYYIL
RFEDIKAAAAFAQTVDYKIDLSELYKYDSAYYLTILVDVEGFPERYPAWLLAKMREFADDSDITRAVLQEHGHLLLVTDA
VSGLQKVECL

Nucleotide


Download         Length: 753 bp        

>NTDB_id=453473 FOC72_RS00990 WP_002893638.1 200446..201198(+) (mecA) [Streptococcus sanguinis strain FDAARGOS_770]
ATGGAAATGAAACAGATTAGTGATTCGACAATAAAAATCACGATTCAGCTGGAAGATTTGGAAGAGCGCGGCATGGAAAT
GGCCGATTTCTTGGTTCCCCAAGAAAAGACGGAAGAATTTTTCTATACCATCTTAGATGAGTTGGAAATGCCGGATAATT
TTTTGGACAGCGGTATGCTGAGCTTCCGTGTGACGCCTAAGCCAGATAAGGTGGATGTTTTTGTTACCAAGTCTAAGTTG
GATAAGAATCTGAGTTTTGAGGATTTGGCAGATTTGCCAGACATGGATGAGCTGTCTCATATGTCTCCAGATGAATTCCT
CAAGACATTGGAAAAGAGCATTTTTGAAAAGAGTAAGGAAGACATAGAAGCAGTCCAATCTTTGGAAACGGCAGAAGCTG
AGGAAGGGGAACAGCTCTCTCAGGAGGCGGCTGATGAGCAGTCGGCGGAAAATGCAGAGCGCTATATTTACTATATCCTG
CGTTTTGAAGATATTAAGGCTGCTGCGGCCTTTGCTCAGACGGTGGACTATAAGATCGACCTATCAGAGCTTTATAAGTA
TGATTCAGCTTATTATTTGACGATTTTGGTAGACGTTGAAGGATTCCCAGAACGCTATCCAGCTTGGCTTTTGGCTAAGA
TGCGTGAATTCGCAGATGATTCAGATATCACTCGGGCAGTGCTGCAGGAGCACGGTCATCTTCTTTTGGTGACAGATGCC
GTCTCCGGCCTGCAGAAGGTTGAATGCCTATGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A859ELL8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

68.826

98.8

0.68
  mecA Streptococcus pneumoniae D39

68.826

98.8

0.68
  mecA Streptococcus pneumoniae R6

68.826

98.8

0.68
  mecA Streptococcus pneumoniae TIGR4

68.421

98.8

0.676
  mecA Streptococcus mutans UA159

49.798

98.8

0.492
  mecA Streptococcus thermophilus LMD-9

48.996

99.6

0.488
  mecA Streptococcus thermophilus LMG 18311

48.594

99.6

0.484