Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   I6H72_RS06355 Genome accession   NZ_CP066055
Coordinates   1267677..1268867 (-) Length   396 a.a.
NCBI ID   WP_198457705.1    Uniprot ID   -
Organism   Streptococcus constellatus strain FDAARGOS_1015     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1262677..1273867
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6H72_RS06330 (I6H72_06330) - 1263206..1263706 (+) 501 WP_198457703.1 YehR family lipoprotein -
  I6H72_RS06335 (I6H72_06335) - 1263793..1263990 (-) 198 WP_003071662.1 DUF951 domain-containing protein -
  I6H72_RS06340 (I6H72_06340) dnaN 1263990..1265126 (-) 1137 WP_006268813.1 DNA polymerase III subunit beta -
  I6H72_RS06345 (I6H72_06345) dnaA 1265283..1266626 (-) 1344 WP_020997506.1 chromosomal replication initiator protein DnaA -
  I6H72_RS06350 (I6H72_06350) spo0J 1266855..1267622 (-) 768 WP_198457704.1 ParB/RepB/Spo0J family partition protein Regulator
  I6H72_RS06355 (I6H72_06355) htrA 1267677..1268867 (-) 1191 WP_198457705.1 S1C family serine protease Regulator
  I6H72_RS06360 (I6H72_06360) rlmH 1269072..1269551 (+) 480 WP_006268880.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6H72_RS06370 (I6H72_06370) - 1269834..1269980 (+) 147 WP_006268843.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  I6H72_RS06375 (I6H72_06375) comD/comD1 1270000..1271313 (+) 1314 WP_232619560.1 GHKL domain-containing protein Regulator
  I6H72_RS06380 (I6H72_06380) comE 1271313..1272062 (+) 750 WP_003071650.1 competence system response regulator transcription factor ComE Regulator

Sequence

Protein


Download         Length: 396 a.a.        Molecular weight: 41772.79 Da        Isoelectric Point: 9.6785

>NTDB_id=453341 I6H72_RS06355 WP_198457705.1 1267677..1268867(-) (htrA) [Streptococcus constellatus strain FDAARGOS_1015]
MKNSSNFTKKLLWLFMVLAIGFIGGLFGNLTSSKLSTNSSTTTKVNKVTTAYKNTNSTTQAVSKVKDAVVSVITYANNNS
QNSVFGNDDSNTNNDNSQQVASEGSGVIYKKDGKYAYLVTNTHVINGAKKVDIRLADGNKVPGEIIGSDTYSDISVVRIS
ADKVKTVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSESGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDVINIINQLEANGTVTRPALGIQMIDITNLSSSDLSRLKLPSKITSGV
VVRSAQSGMPAEGKLQKYDVITKVDDKEISSTSDLQSALYKHSIGDNIKITFYRDGKETTTTIKLTKSTKDLDSNN

Nucleotide


Download         Length: 1191 bp        

>NTDB_id=453341 I6H72_RS06355 WP_198457705.1 1267677..1268867(-) (htrA) [Streptococcus constellatus strain FDAARGOS_1015]
ATGAAAAATTCTTCAAATTTTACAAAAAAATTATTATGGCTTTTCATGGTCTTAGCTATAGGTTTTATTGGTGGTTTATT
TGGAAACTTAACCTCATCAAAATTATCAACAAATAGTTCTACAACAACTAAGGTTAACAAAGTTACTACTGCTTATAAAA
ATACAAATTCTACAACACAAGCTGTAAGCAAAGTAAAGGATGCAGTTGTATCTGTTATTACCTATGCTAATAATAATTCT
CAAAATAGTGTTTTTGGAAATGATGATTCAAATACTAATAACGATAATTCTCAACAAGTAGCTAGTGAAGGATCTGGGGT
TATTTATAAAAAAGACGGAAAATACGCCTACTTAGTGACCAATACCCATGTTATTAATGGTGCTAAAAAAGTTGATATTC
GTTTGGCTGATGGGAATAAAGTTCCTGGAGAAATTATAGGTTCAGATACTTATTCTGATATCTCTGTTGTTCGTATTAGT
GCTGATAAAGTAAAAACAGTTGCTGAATTTGGAGATTCTAGTAAATTAACTGTTGGTGAAACAGCTATTGCGATTGGAAG
TCCACTCGGATCAAATTATGCTAATACTGTGACACAAGGAATTATTTCTAGCTTAAATCGTAATGTGTCTTTAAAATCTG
AAAGCGGTCAAACCATTTCAACACAAGCTATCCAAACTGATACAGCTATCAATCCAGGGAATTCTGGTGGTCCACTTGTA
AATATCCAAGGACAAGTAATTGGTATTACTTCAAGTAAAATAGCTAGCAACGGCGGAACTTCGGTTGAAGGATTAGGATT
TGCTATTCCATCTAATGATGTTATAAACATTATTAACCAGTTAGAAGCAAATGGAACTGTTACACGACCAGCTCTAGGAA
TCCAAATGATTGACATCACTAATCTGTCTAGTTCAGATCTATCACGCTTAAAACTTCCATCAAAAATAACTAGTGGAGTT
GTCGTACGTTCAGCTCAATCTGGAATGCCAGCTGAAGGAAAACTTCAAAAATATGATGTGATTACAAAAGTAGATGATAA
AGAAATTTCTTCAACAAGTGATTTACAATCCGCTTTATACAAACATTCAATTGGTGACAACATAAAAATCACTTTCTATC
GTGATGGAAAAGAAACTACTACTACCATTAAGCTTACAAAATCTACAAAAGATTTAGATTCAAATAATTGA

Domains

Predicted by InterProScan.

Trypsin-like peptidase domain (Trypsin_2)

(104-249)

Peptidase family M50 (Peptidase_M50)

(266-390)

PDZ domain (PDZ_2)

(290-385)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

75

100

0.758
  htrA Streptococcus mitis NCTC 12261

72.544

100

0.727
  htrA Streptococcus pneumoniae Rx1

72.292

100

0.725
  htrA Streptococcus pneumoniae D39

72.292

100

0.725
  htrA Streptococcus pneumoniae R6

72.292

100

0.725
  htrA Streptococcus pneumoniae TIGR4

72.292

100

0.725
  htrA Streptococcus mutans UA159

55.584

99.495

0.553