Detailed information NTG0045249

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SDSE_RS20205
• Genome accession: NC_019042
• Coordinates: 1961684..1962424 (-)
• Length: 246 a.a.
• NCBI ID: WP_003061418.1
• Uniprot ID: Q8KQN2
• Organism: Streptococcus dysgalactiae subsp. equisimilis AC-2713
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1956684..1967424

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SDSE_RS20180 (S_dysgal_equisimilis_AC2713_2016)	-	1957582..1958286 (-)	705	WP_003056091.1	N-acetylmannosamine-6-phosphate 2-epimerase	-
SDSE_RS20185 (S_dysgal_equisimilis_AC2713_2018)	rpmH	1958617..1958751 (-)	135	WP_002885866.1	50S ribosomal protein L34	-
SDSE_RS20190 (S_dysgal_equisimilis_AC2713_2019)	jag	1959064..1959978 (-)	915	WP_015058067.1	RNA-binding cell elongation regulator Jag/EloR	-
SDSE_RS20195 (S_dysgal_equisimilis_AC2713_2020)	-	1959990..1960817 (-)	828	WP_155115634.1	YidC/Oxa1 family membrane protein insertase	-
SDSE_RS20200 (S_dysgal_equisimilis_AC2713_2021)	rnpA	1960783..1961142 (-)	360	WP_003056083.1	ribonuclease P protein component	-
SDSE_RS20205 (S_dysgal_equisimilis_AC2713_2022)	comE/blpR	1961684..1962424 (-)	741	WP_003061418.1	LytTR family DNA-binding domain-containing protein	Regulator
SDSE_RS20210 (S_dysgal_equisimilis_AC2713_2023)	-	1962428..1963711 (-)	1284	WP_015058069.1	sensor histidine kinase	-
SDSE_RS20215 (S_dysgal_equisimilis_AC2713_2024)	-	1963712..1965055 (-)	1344	WP_015058070.1	GHKL domain-containing protein	-
SDSE_RS20220 (S_dysgal_equisimilis_AC2713_2025)	gltX	1965669..1967117 (-)	1449	WP_003053372.1	glutamate--tRNA ligase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28977.28 Da
• Isoelectric Point: 4.8645

>NTDB_id=45249 SDSE_RS20205 WP_003061418.1 1961684..1962424(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis AC-2713]
MMNIFILEDDFIQQTRIESVVADILEEAKIPCNQLEVFANPHKLFESIQERGDHQLYFLDIEIGDEDRRGLELAADIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAVDKQQFRDQIEECIRYTYEMMSSRESEDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFDNGDSCMVSRLKMKCLFE
KWEALH

Nucleotide

• Length: 741 bp

>NTDB_id=45249 SDSE_RS20205 WP_003061418.1 1961684..1962424(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis AC-2713]
ATGATGAATATTTTTATTCTTGAAGATGATTTTATCCAACAGACACGTATTGAATCTGTAGTGGCAGACATCTTGGAAGA
AGCTAAAATCCCTTGTAATCAGCTAGAAGTGTTTGCCAATCCTCATAAATTATTTGAAAGCATTCAAGAAAGAGGCGATC
ACCAGCTATATTTTTTAGACATTGAGATTGGTGATGAGGATCGCCGAGGGCTTGAATTGGCAGCAGATATTCGACAAAAA
GACCCCAATGCGGTCATTGTGTTTGTTACCACACATTCTGAATTTGCTCCTATTTCTTTTAAATACAAAGTGTCTGCCTT
AGATTTTATTGACAAAGCAGTTGATAAACAACAATTTAGGGATCAGATTGAAGAATGTATCCGCTATACCTATGAGATGA
TGTCTAGCCGAGAATCAGAAGACATGTTTCTATTTGAGACCCCTCAGACAAGATTGAAACTACCTTACAAAGATATCCTT
TATTTTGCCACTGCTACGACACCCCACAAGGTGTGTTTGTGGACTCAGACGGAGAGACTGGAGTTTTATGGTAATTTATC
TGAGATACAAGCTGTGGCTCCAAAGCTTTTCTTATGCCATAGATCTTACTTGGTTAATCTAGATAAGGTTGTGCGTATTG
ATAAATCCAAACAGCTCCTCTATTTCGATAATGGGGATTCCTGTATGGTCTCACGCTTAAAAATGAAATGCCTTTTTGAA
AAATGGGAAGCCTTACATTAA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (152-242)

3D structure

• AlphaFold DB: Q8KQN2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	47.699	97.154	0.463
comE/comE1	Streptococcus equinus JB1	42.437	96.748	0.411
comE/comE2	Streptococcus equinus JB1	40.408	99.593	0.402
comE/comE2	Streptococcus gordonii strain NCTC7865	39.113	100	0.394
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	39.113	100	0.394