Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   HRE60_RS00845 Genome accession   NZ_CP054153
Coordinates   155267..156016 (+) Length   249 a.a.
NCBI ID   WP_073687445.1    Uniprot ID   A0A7X2W6N7
Organism   Streptococcus salivarius strain DB-B5     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 150267..161016
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HRE60_RS00825 (HRE60_00825) - 151280..152020 (-) 741 WP_002886432.1 amino acid ABC transporter ATP-binding protein -
  HRE60_RS00830 (HRE60_00830) - 152020..153567 (-) 1548 WP_181670871.1 ABC transporter substrate-binding protein/permease -
  HRE60_RS00835 (HRE60_00835) - 153773..154627 (+) 855 WP_002883622.1 undecaprenyl-diphosphate phosphatase -
  HRE60_RS00840 (HRE60_00840) - 154689..155060 (-) 372 WP_022496532.1 DUF3021 family protein -
  HRE60_RS00845 (HRE60_00845) mecA 155267..156016 (+) 750 WP_073687445.1 adaptor protein MecA Regulator
  HRE60_RS00850 (HRE60_00850) - 156020..157177 (+) 1158 WP_014633818.1 MraY family glycosyltransferase -
  HRE60_RS00855 (HRE60_00855) sufC 157339..158109 (+) 771 WP_002883600.1 Fe-S cluster assembly ATPase SufC -
  HRE60_RS00860 (HRE60_00860) sufD 158146..159408 (+) 1263 WP_181670872.1 Fe-S cluster assembly protein SufD -
  HRE60_RS00865 (HRE60_00865) - 159462..160694 (+) 1233 WP_181670873.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29098.67 Da        Isoelectric Point: 4.0182

>NTDB_id=451143 HRE60_RS00845 WP_073687445.1 155267..156016(+) (mecA) [Streptococcus salivarius strain DB-B5]
MEMKQISETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEDLDFNDLSDMDDYSGLSPEEFLKALEGNFMDKGDIEAHHKLEELEKTLEEVDKAMTEPTKEVPEENIREDYTHYVLAF
SDFDQVVTFTQGLKDVPVEGSELYKLGDVYYMTVLLYLADEPDYYANNMYARFLEYANVADRTRAYLQEHATILMEEDAL
PVLQATKWS

Nucleotide


Download         Length: 750 bp        

>NTDB_id=451143 HRE60_RS00845 WP_073687445.1 155267..156016(+) (mecA) [Streptococcus salivarius strain DB-B5]
ATGGAAATGAAACAAATAAGCGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAATT
GAAGGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT
TTAAAAATAGTGGGATGCTGAGCTTCCGTGTCACGCCACGCAAGGATCGTGTGGATGTCTTTGTGACTAAATCAGATCTT
AAGGAAGACCTTGATTTCAACGATTTGTCAGATATGGATGACTACTCAGGGCTTTCTCCAGAAGAGTTCCTCAAGGCTCT
TGAGGGTAACTTTATGGACAAGGGTGACATCGAAGCACACCATAAGCTCGAAGAGCTTGAAAAGACCTTGGAAGAGGTTG
ATAAGGCTATGACAGAGCCTACCAAGGAAGTGCCCGAAGAAAATATTCGTGAAGACTATACCCACTATGTCTTGGCCTTC
TCTGACTTTGATCAAGTGGTGACCTTTACACAAGGCTTGAAGGATGTGCCTGTTGAAGGTTCTGAGCTTTATAAACTTGG
GGATGTCTACTATATGACAGTCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTAGCAGACCGAACACGTGCCTACCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTACTACAAGCAACGAAATGGAGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7X2W6N7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus thermophilus LMD-9

93.574

100

0.936
  mecA Streptococcus thermophilus LMG 18311

92.771

100

0.928
  mecA Streptococcus mutans UA159

60.656

97.992

0.594
  mecA Streptococcus pneumoniae Rx1

46.988

100

0.47
  mecA Streptococcus pneumoniae D39

46.988

100

0.47
  mecA Streptococcus pneumoniae R6

46.988

100

0.47
  mecA Streptococcus pneumoniae TIGR4

46.988

100

0.47