Detailed information NTG0450127

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: FOC63_RS02710
• Genome accession: NZ_CP054015
• Coordinates: 554527..555255 (-)
• Length: 242 a.a.
• NCBI ID: WP_012962512.1
• Uniprot ID: A0A139R4K2
• Organism: Streptococcus gallolyticus strain FDAARGOS_755
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 549527..560255

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FOC63_RS02685 (FOC63_02685)	rsgA	549751..550623 (-)	873	WP_009854990.1	ribosome small subunit-dependent GTPase A	-
FOC63_RS02700 (FOC63_02700)	-	552818..553018 (-)	201	WP_009854991.1	hypothetical protein	-
FOC63_RS02705 (FOC63_02705)	comD/comD3	553150..554514 (-)	1365	WP_009854992.1	sensor histidine kinase	Regulator
FOC63_RS02710 (FOC63_02710)	comE/comE2	554527..555255 (-)	729	WP_012962512.1	LytR/AlgR family response regulator transcription factor	Regulator
FOC63_RS02715 (FOC63_02715)	-	555354..555647 (-)	294	WP_009854994.1	bacteriocin immunity protein	-
FOC63_RS02720 (FOC63_02720)	-	555698..555925 (-)	228	WP_009854995.1	hypothetical protein	-
FOC63_RS02725 (FOC63_02725)	-	556195..556506 (-)	312	WP_003066564.1	bacteriocin immunity protein	-
FOC63_RS02730 (FOC63_02730)	-	556518..556667 (-)	150	WP_009854997.1	hypothetical protein	-
FOC63_RS02735 (FOC63_02735)	-	556677..556976 (-)	300	WP_009854998.1	DUF3884 family protein	-
FOC63_RS02740 (FOC63_02740)	-	557276..557413 (+)	138	WP_009854999.1	hypothetical protein	-
FOC63_RS02745 (FOC63_02745)	-	557435..558742 (-)	1308	WP_009855000.1	sensor histidine kinase	-
FOC63_RS02750 (FOC63_02750)	comE/comE1	558750..559481 (-)	732	WP_009855001.1	response regulator transcription factor	Regulator
FOC63_RS02755 (FOC63_02755)	-	559498..559782 (-)	285	WP_231101259.1	LytTR family DNA-binding domain-containing protein	-
FOC63_RS02760 (FOC63_02760)	-	560025..560225 (-)	201	WP_009855003.1	hypothetical protein	-

Sequence

Protein

• Length: 242 a.a.
• Molecular weight: 28063.45 Da
• Isoelectric Point: 6.7499

>NTDB_id=450127 FOC63_RS02710 WP_012962512.1 554527..555255(-) (comE/comE2) [Streptococcus gallolyticus strain FDAARGOS_755]
MIDIYVLEDDVNQQFRLEKMIDEVLVDNQWQHRCFELFGEPSRLITLIDETVPQIFFLDLDINGDKTKGIEVAKAIRDVS
KTATLVFVTTHSEFMLLTYRAQVSALDFIDKTDSDLAIKENLQACLKKVVEGQVPRLSLDTFIFENNKTKIRIPFEDILY
FETAEAHRLMLVTRTGQRNFYGTIREVKKANHKLFQCHKSYLINPDNVVSLDKKEGLVYFVGGKSCYVSKKHMKELKTKL
ES

Nucleotide

• Length: 729 bp

>NTDB_id=450127 FOC63_RS02710 WP_012962512.1 554527..555255(-) (comE/comE2) [Streptococcus gallolyticus strain FDAARGOS_755]
ATGATTGATATTTATGTTTTGGAAGATGACGTAAATCAGCAGTTTCGCTTGGAAAAAATGATTGACGAGGTGCTTGTGGA
CAATCAGTGGCAACATCGTTGTTTTGAATTGTTTGGTGAGCCTAGTCGTCTTATCACTCTTATTGATGAAACGGTTCCTC
AAATCTTTTTCTTGGATTTGGATATCAATGGCGATAAAACGAAAGGAATTGAAGTTGCCAAGGCGATTAGAGACGTTTCG
AAAACAGCAACACTTGTCTTTGTTACAACGCATTCTGAATTTATGCTCCTGACCTATCGTGCGCAAGTCAGTGCCCTTGA
TTTCATTGATAAAACCGACAGTGACTTGGCAATCAAGGAAAATTTGCAGGCTTGTTTAAAGAAAGTCGTTGAAGGACAAG
TGCCTCGCCTAAGCTTGGATACCTTTATTTTTGAAAACAATAAAACCAAAATCAGAATACCATTTGAAGATATTCTTTAT
TTTGAAACGGCGGAAGCGCACCGTTTGATGTTGGTGACACGGACAGGACAGCGTAATTTTTACGGAACAATTAGAGAAGT
TAAAAAGGCAAATCATAAGCTATTTCAATGCCATAAATCCTATCTGATTAATCCTGATAATGTCGTCAGTTTGGATAAAA
AAGAAGGGCTTGTTTATTTTGTAGGTGGAAAATCTTGCTACGTTTCCAAAAAACACATGAAAGAATTAAAAACTAAACTA
GAAAGTTAG

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-240)

• Response regulator receiver domain (Response_reg) (5-113)

3D structure

• AlphaFold DB: A0A139R4K2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus equinus JB1	70.248	100	0.702
comE/comE1	Streptococcus equinus JB1	43.802	100	0.438
comE/blpR	Streptococcus mutans UA159	42.739	99.587	0.426