Detailed information NTG0450128

Bioinformatically predicted

Overview

• Name: comE/comE1
• Type: Regulator
• Locus tag: FOC63_RS02750
• Genome accession: NZ_CP054015
• Coordinates: 558750..559481 (-)
• Length: 243 a.a.
• NCBI ID: WP_009855001.1
• Uniprot ID: A0A380K1N3
• Organism: Streptococcus gallolyticus strain FDAARGOS_755
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 553750..564481

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FOC63_RS02710 (FOC63_02710)	comE/comE2	554527..555255 (-)	729	WP_012962512.1	LytR/AlgR family response regulator transcription factor	Regulator
FOC63_RS02715 (FOC63_02715)	-	555354..555647 (-)	294	WP_009854994.1	bacteriocin immunity protein	-
FOC63_RS02720 (FOC63_02720)	-	555698..555925 (-)	228	WP_009854995.1	hypothetical protein	-
FOC63_RS02725 (FOC63_02725)	-	556195..556506 (-)	312	WP_003066564.1	bacteriocin immunity protein	-
FOC63_RS02730 (FOC63_02730)	-	556518..556667 (-)	150	WP_009854997.1	hypothetical protein	-
FOC63_RS02735 (FOC63_02735)	-	556677..556976 (-)	300	WP_009854998.1	DUF3884 family protein	-
FOC63_RS02740 (FOC63_02740)	-	557276..557413 (+)	138	WP_009854999.1	hypothetical protein	-
FOC63_RS02745 (FOC63_02745)	-	557435..558742 (-)	1308	WP_009855000.1	sensor histidine kinase	-
FOC63_RS02750 (FOC63_02750)	comE/comE1	558750..559481 (-)	732	WP_009855001.1	response regulator transcription factor	Regulator
FOC63_RS02755 (FOC63_02755)	-	559498..559782 (-)	285	WP_231101259.1	LytTR family DNA-binding domain-containing protein	-
FOC63_RS02760 (FOC63_02760)	-	560025..560225 (-)	201	WP_009855003.1	hypothetical protein	-
FOC63_RS02765 (FOC63_02765)	-	560547..561560 (-)	1014	WP_009855005.1	bacteriocin biosynthesis protein	-
FOC63_RS02770 (FOC63_02770)	-	562618..562815 (-)	198	WP_009855009.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
FOC63_RS02775 (FOC63_02775)	-	562834..563085 (-)	252	WP_009855010.1	bacteriocin class II family protein	-
FOC63_RS02780 (FOC63_02780)	-	563332..563589 (+)	258	WP_009855011.1	hypothetical protein	-

Sequence

Protein

• Length: 243 a.a.
• Molecular weight: 28456.61 Da
• Isoelectric Point: 5.4335

>NTDB_id=450128 FOC63_RS02750 WP_009855001.1 558750..559481(-) (comE/comE1) [Streptococcus gallolyticus strain FDAARGOS_755]
MLDIYVLEDNIIQQFRMEREIATIMAKNNWDYQRIEVFSSANEIIAKATEKGEHQIFFLDLEIRDDEKQGIDVAKAIREK
DATAIIVFVTTHSEFMLLTYQALVGAIDFIDKNLNDQAFSERIELCLKEAMKHQNDNFGENSFLFETPKARVRMPYSDIL
YFETSPAVHRVIMHTKNDRMEFYATIAEIAKSDKRLFKCHRSFIINVDNVVRFDKATRSVYFETGDTCLVSRDKIKPLLN
EMR

Nucleotide

• Length: 732 bp

>NTDB_id=450128 FOC63_RS02750 WP_009855001.1 558750..559481(-) (comE/comE1) [Streptococcus gallolyticus strain FDAARGOS_755]
ATGTTAGATATTTATGTACTAGAGGATAATATCATACAGCAATTTCGTATGGAACGCGAGATTGCGACCATTATGGCAAA
AAATAATTGGGACTATCAGAGAATAGAGGTGTTTAGTTCCGCAAATGAGATTATAGCTAAGGCAACTGAAAAAGGAGAGC
ATCAAATTTTCTTTCTTGATTTAGAAATCAGAGACGACGAAAAACAAGGAATTGATGTCGCTAAAGCTATTCGTGAAAAA
GATGCAACAGCTATCATTGTTTTTGTAACAACTCATTCAGAATTTATGCTGCTGACCTACCAAGCGTTAGTAGGGGCAAT
TGATTTTATTGATAAGAACCTGAATGACCAAGCATTTAGTGAACGCATAGAGTTGTGCCTAAAGGAAGCCATGAAACATC
AAAATGATAATTTCGGCGAAAACTCCTTTTTATTTGAAACTCCTAAAGCACGTGTGCGCATGCCATATAGTGACATTCTC
TATTTTGAAACCTCTCCTGCTGTGCACCGCGTGATTATGCATACGAAAAATGACAGAATGGAATTTTATGCAACGATTGC
AGAGATTGCTAAATCAGACAAACGTCTTTTTAAGTGTCATCGTTCTTTTATTATTAATGTGGATAATGTGGTCAGATTTG
ATAAAGCGACACGAAGTGTTTATTTCGAAACTGGGGACACTTGCCTAGTTTCTAGAGATAAAATAAAACCTCTATTAAAT
GAGATGAGGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (11-123)

• LytTr DNA-binding domain (LytTR) (152-238)

3D structure

• AlphaFold DB: A0A380K1N3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE1	Streptococcus equinus JB1	71.605	100	0.716
comE/blpR	Streptococcus mutans UA159	47.699	98.354	0.469
comE/comE2	Streptococcus equinus JB1	46.694	99.588	0.465